Assessment of Structural Intolerance and Durability
General Structure Information 3uvj GUCY1A3 crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. 2.08Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ESSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2k27 PAX8 solution structure of human pax8 paired box domain -1.0Å AUTH L.CODUTTI,H.VAN INGEN,C.VASCOTTO,F.FOGOLARI,AUTH 2 A.CORAZZA,G.TELL,F.QUADRIFOGLIO,P.VIGLINO,AUTH 3 R.BOELENS,G.ESPOSITOTITL THE SOLUTION STRUCTURE OF DNA-FREE PAX-8 PAIRED BOXTITL 2 DOMAIN ACCOUNTS FOR REDOX REGULATION OFTITL 3 TRANSCRIPTIONAL ACTIVITY IN THE PAX PROTEIN FAMILY.REF J.BIOL.CHEM. V. 283 33321 2008REFN ISSN 0021-9258PMID 18829450DOI 10.1074/JBC.M805717200 Variant Set […]
General Structure Information 4gtu GSTM4 ligand-free homodimeric human glutathione s-transferase m4-4 3.3Å AUTH Y.V.PATSKOVSKY,L.N.PATSKOVSKA,I.LISTOWSKYTITL AN ASPARAGINE-PHENYLALANINE SUBSTITUTION ACCOUNTS FORTITL 2 CATALYTIC DIFFERENCES BETWEEN HGSTM3-3 AND OTHER HUMAN CLASSTITL 3 MU GLUTATHIONE S-TRANSFERASES.REF BIOCHEMISTRY V. 38 16187 1999REFN ISSN 0006-2960PMID 10587441DOI 10.1021/BI991714T Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3qx3 TOP2B human topoisomerase iibeta in complex with dna and etoposide 2.16Å AUTH C.C.WU,T.K.LI,L.FARH,L.Y.LIN,T.S.LIN,Y.J.YU,T.J.YEN,AUTH 2 C.W.CHIANG,N.L.CHANTITL STRUCTURAL BASIS OF TYPE II TOPOISOMERASE INHIBITION BY THETITL 2 ANTICANCER DRUG ETOPOSIDEREF SCIENCE V. 333 459 2011REFN ISSN 0036-8075PMID 21778401DOI 10.1126/SCIENCE.1204117 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2c6y FOXK2 crystal structure of interleukin enhancer-binding factor 1 bound to dna 2.4Å AUTH K.-L.TSAI,C.-Y.HUANG,C.-H.CHANG,Y.-J.SUN,AUTH 2 W.-J.CHUANG,C.-D.HSIAOTITL CRYSTAL STRUCTURE OF THE HUMAN FOXK1A-DNA COMPLEXTITL 2 AND ITS IMPLICATIONS ON THE DIVERSE BINDINGTITL 3 SPECIFICITY OF WINGED HELIX/FORKHEAD PROTEINS.REF J.BIOL.CHEM. V. 281 17400 2006REFN ISSN 0021-9258PMID 16624804DOI 10.1074/JBC.M600478200 Variant Set Distributions Mapped Variants
General Structure Information 3gut RELA crystal structure of a higher-order complex of p50:rela bound to the hiv-1 ltr 3.59Å AUTH J.C.STROUD,A.OLTMAN,A.HAN,D.L.BATES,L.CHENTITL STRUCTURAL BASIS OF HIV-1 ACTIVATION BYTITL 2 NF-KAPPAB–A HIGHER-ORDER COMPLEX OF P50:RELA BOUNDTITL 3 TO THE HIV-1 LTR.REF J.MOL.BIOL. V. 393 98 2009REFN ISSN 0022-2836PMID 19683540DOI 10.1016/J.JMB.2009.08.023 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2enj PRKCQ solution sturcture of the c2 domain from human protein kinase c theta -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STURCTURE OF THE C2 DOMAIN FROM HUMANTITL 2 PROTEIN KINASE C THETAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1u3b APBA1 auto-inhibition mechanism of x11s/mints family scaffold proteins revealed by the closed conformation of the tandem pdz domains -1.0Å AUTH J.-F.LONG,W.FENG,R.WANG,L.-N.CHAN,F.C.IP,J.XIA,AUTH 2 N.Y.IP,M.ZHANGTITL AUTOINHIBITION OF X11/MINT SCAFFOLD PROTEINSTITL 2 REVEALED BY THE CLOSED CONFORMATION OF THE PDZTITL 3 TANDEMREF NAT.STRUCT.MOL.BIOL. V. 12 722 2005REFN ISSN 1545-9993PMID 16007100DOI 10.1038/NSMB958 Variant Set Distributions […]
General Structure Information 3g45 PDE4B crystal structure of human phosphodiesterase 4b with regulatory domain and d155988 2.63Å AUTH A.B.BURGIN,O.T.MAGNUSSON,J.SINGH,P.WITTE,AUTH 2 B.L.STAKER,J.M.BJORNSSON,M.THORSTEINSDOTTIR,AUTH 3 S.HRAFNSDOTTIR,T.HAGEN,A.S.KISELYOV,L.J.STEWART,AUTH 4 M.E.GURNEYTITL DESIGN OF PHOSPHODIESTERASE 4D (PDE4D) ALLOSTERICTITL 2 MODULATORS FOR ENHANCING COGNITION WITH IMPROVEDTITL 3 SAFETY.REF NAT.BIOTECHNOL. V. 28 63 2010REFN ISSN 1087-0156PMID 20037581DOI 10.1038/NBT.1598 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3ks9 GRM1 metabotropic glutamate receptor mglur1 complexed with ly341495 antagonist 1.9Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR1 COMPLEXED WITHTITL 2 LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants