Assessment of Structural Intolerance and Durability
General Structure Information 4kfz LMO2 crystal structure of lmo2 and anti-lmo2 vh complex 2.8Å AUTH H.SEWELL,T.TANAKA,K.E.OMARI,E.J.MANCINI,A.CRUZ,AUTH 2 N.FERNANDEZ-FUENTES,J.CHAMBERS,T.H.RABBITTSTITL CONFORMATIONAL FLEXIBILITY OF THE ONCOGENIC PROTEIN LMO2TITL 2 PRIMES THE FORMATION OF THE MULTI-PROTEIN TRANSCRIPTIONTITL 3 COMPLEX.REF SCI REP V. 4 3643 2014REFN ESSN 2045-2322PMID 24407558DOI 10.1038/SREP03643 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4gbx HLA-DMB crystal structure of an immune complex at ph 6.5 3.0Å AUTH W.POS,D.K.SETHI,M.J.CALL,M.S.SCHULZE,A.K.ANDERS,J.PYRDOL,AUTH 2 K.W.WUCHERPFENNIGTITL CRYSTAL STRUCTURE OF THE HLA-DM-HLA-DR1 COMPLEX DEFINESTITL 2 MECHANISMS FOR RAPID PEPTIDE SELECTION.REF CELL(CAMBRIDGE,MASS.) V. 151 1557 2012REFN ISSN 0092-8674PMID 23260142DOI 10.1016/J.CELL.2012.11.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1rby GART human gar tfase complex structure with 10-(trifluoroacetyl)- 5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid and substrate beta-gar 2.1Å AUTH Y.ZHANG,J.DESHARNAIS,D.L.BOGER,I.A.WILSONTITL HUMAN GAR TFASE COMPLEX STRUCTUREREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3f8u PDIA3 tapasin/erp57 heterodimer 2.6Å AUTH G.DONG,P.A.WEARSCH,D.R.PEAPER,P.CRESSWELL,K.M.REINISCHTITL INSIGHTS INTO MHC CLASS I PEPTIDE LOADING FROM THE STRUCTURETITL 2 OF THE TAPASIN-ERP57 THIOL OXIDOREDUCTASE HETERODIMER.REF IMMUNITY V. 30 21 2009REFN ISSN 1074-7613PMID 19119025DOI 10.1016/J.IMMUNI.2008.10.018 Variant Set Distributions Mapped Variants
General Structure Information 1axc PCNA human pcna 2.6Å AUTH J.M.GULBIS,Z.KELMAN,J.HURWITZ,M.ODONNELL,J.KURIYANTITL STRUCTURE OF THE C-TERMINAL REGION OFTITL 2 P21(WAF1/CIP1) COMPLEXED WITH HUMAN PCNA.REF CELL(CAMBRIDGE,MASS.) V. 87 297 1996REFN ISSN 0092-8674PMID 8861913DOI 10.1016/S0092-8674(00)81347-1 Variant Set Distributions Mapped Variants
General Structure Information 3n06 PRLR a mutant human prolactin receptor antagonist h27a in complex with the extracellular domain of the human prolactin receptor 2.0Å AUTH M.V.KULKARNI,M.C.TETTAMANZI,J.W.MURPHY,C.KEELER,D.G.MYSZKA,AUTH 2 N.E.CHAYEN,E.J.LOLIS,M.E.HODSDONTITL TWO INDEPENDENT HISTIDINES, ONE IN HUMAN PROLACTIN AND ONETITL 2 IN ITS RECEPTOR, ARE CRITICAL FOR PH-DEPENDENT RECEPTORTITL 3 RECOGNITION AND ACTIVATION.REF J.BIOL.CHEM. V. 285 38524 2010REFN […]
General Structure Information 1pvh LIF crystal structure of leukemia inhibitory factor in complex with gp130 2.5Å AUTH M.J.BOULANGER,A.J.BANKOVICH,T.KORTEMME,D.BAKER,AUTH 2 K.C.GARCIATITL CONVERGENT MECHANISMS FOR RECOGNITION OF DIVERGENTTITL 2 CYTOKINES BY THE SHARED SIGNALING RECEPTOR GP130.REF MOL.CELL V. 12 577 2003REFN ISSN 1097-2765PMID 14527405DOI 10.1016/S1097-2765(03)00365-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1n8s PNLIP structure of the pancreatic lipase-colipase complex 3.04Å AUTH H.VAN TILBEURGH,L.SARDA,R.VERGER,C.CAMBILLAUTITL STRUCTURE OF THE PANCREATIC LIPASE-PROCOLIPASETITL 2 COMPLEXREF NATURE V. 359 159 1992REFN ISSN 0028-0836PMID 1522902DOI 10.1038/359159A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3es6 PIP crystal structure of the novel complex formed between zinc 2- glycoprotein (zag) and prolactin inducible protein (pip) from human seminal plasma 3.23Å AUTH M.I.HASSAN,S.BILGRAMI,V.KUMAR,N.SINGH,S.YADAV,P.KAUR,AUTH 2 T.P.SINGHTITL CRYSTAL STRUCTURE OF THE NOVEL COMPLEX FORMED BETWEEN ZINCTITL 2 ALPHA2-GLYCOPROTEIN (ZAG) AND PROLACTIN-INDUCIBLE PROTEINTITL 3 (PIP) FROM HUMAN SEMINAL PLASMAREF J.MOL.BIOL. V. 384 […]
General Structure Information 2oo0 ODC1 a structural insight into the inhibition of human and leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane 1.9Å AUTH V.T.DUFE,D.INGNER,O.HEBY,A.R.KHOMUTOV,L.PERSSON,AUTH 2 S.AL-KARADAGHITITL A STRUCTURAL INSIGHT INTO THE INHIBITION OF HUMAN ANDTITL 2 LEISHMANIA DONOVANI ORNITHINE DECARBOXYLASES BYTITL 3 1-AMINO-OXY-3-AMINOPROPANE.REF BIOCHEM.J. V. 405 261 2007REFN ISSN 0264-6021PMID 17407445DOI 10.1042/BJ20070188 Variant Set Distributions Ripley’s […]