Assessment of Structural Intolerance and Durability
General Structure Information 4bhw EP300 structural basis for autoinhibition of the acetyltransferase activity of p300 2.8Å AUTH M.DELVECCHIO,J.GAUCHER,C.AGUILAR-GURRIERI,E.ORTEGA,D.PANNETITL STRUCTURE OF THE P300 CATALYTIC CORE AND IMPLICATIONS FORTITL 2 CHROMATIN TARGETING AND HAT REGULATIONREF NAT.STRUCT.MOL.BIOL. V. 20 1040 2013REFN ISSN 1545-9993PMID 23934153DOI 10.1038/NSMB.2642 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3s97 CNTN1 ptprz cntn1 complex 2.3Å AUTH S.LAMPRIANOU,E.CHATZOPOULOU,J.L.THOMAS,S.BOUYAIN,S.HARROCHTITL A COMPLEX BETWEEN CONTACTIN-1 AND THE PROTEIN TYROSINETITL 2 PHOSPHATASE PTPRZ CONTROLS THE DEVELOPMENT OFTITL 3 OLIGODENDROCYTE PRECURSOR CELLS.REF PROC.NATL.ACAD.SCI.USA V. 108 17498 2011REFN ISSN 0027-8424PMID 21969550DOI 10.1073/PNAS.1108774108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l4r KCNH2 nmr solution structure of the n-terminal pas domain of herg -1.0Å AUTH Q.LI,S.GAYEN,A.S.CHEN,Q.HUANG,M.RAIDA,C.KANGTITL NMR SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF HERG ANDTITL 2 ITS INTERACTION WITH THE S4-S5 LINKER.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 403 126 2010REFN ISSN 0006-291XPMID 21055387DOI 10.1016/J.BBRC.2010.10.132 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1wch PTPN13 crystal structure of ptpl1 human tyrosine phosphatase mutated in colorectal cancer – evidence for a second phosphotyrosine substrate recognition pocket 1.85Å AUTH F.VILLA,M.DEAK,G.B.BLOOMBERG,D.R.ALESSI,AUTH 2 D.M.F.VAN AALTENTITL CRYSTAL STRUCTURE OF PTPL1/FAP-1 HUMAN TYROSINETITL 2 PHOSPHATASE MUTATED IN COLORECTAL CANCER:TITL 3 EVEIDENCE FOR A SECOND PHOSPHOTYROSINE SUBSTRATETITL 4 RECOGNITION POCKETREF J.BIOL.CHEM. V. […]
General Structure Information 2ffu GALNT2 crystal structure of human ppgalnact-2 complexed with udp and ea2 1.64Å AUTH T.A.FRITZ,J.RAMAN,L.A.TABAKTITL DYNAMIC ASSOCIATION BETWEEN THE CATALYTIC ANDTITL 2 LECTIN DOMAINS OF HUMAN UDP-GALNAC:POLYPEPTIDETITL 3 {ALPHA}-N-ACETYLGALACTOSAMINYLTRANSFERASE-2REF J.BIOL.CHEM. V. 281 8613 2006REFN ISSN 0021-9258PMID 16434399DOI 10.1074/JBC.M513590200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2qnd FMR1 crystal structure of the kh1-kh2 domains from human fragile x mental retardation protein 1.9Å AUTH R.VALVERDE,I.POZDNYAKOVA,T.KAJANDER,J.VENKATRAMAN,L.REGANTITL FRAGILE X MENTAL RETARDATION SYNDROME: STRUCTURE OF THETITL 2 KH1-KH2 DOMAINS OF FRAGILE X MENTAL RETARDATION PROTEIN.REF STRUCTURE V. 15 1090 2007REFN ISSN 0969-2126PMID 17850748DOI 10.1016/J.STR.2007.06.022 Variant Set Distributions Mapped Variants
General Structure Information 4ark MAP2K1 crystal structure of the catalytic domain of human map kinase kinase 1 (mek1) in complex with a small molecule inhibitor and adp 2.6Å AUTH I.V.HARTUNG,M.HITCHCOCK,F.PUEHLER,R.NEUHAUS,A.SCHOLZ,AUTH 2 S.HAMMER,K.PETERSEN,G.SIEMEISTER,D.BRITTAIN,R.C.HILLIGTITL OPTIMIZATION OF ALLOSTERIC MEK INHIBITORS – PART 1:TITL 2 VENTURING INTO UNEXPLORED SAR TERRITORIESREF BIOORG.MED.CHEM.LETT. V. 23 2384 2013REFN ISSN 0960-894XPMID 23474388DOI 10.1016/J.BMCL.2013.02.028 […]
General Structure Information 2ee2 CNTN1 solution structures of the fn3 domain of human contactin 1 -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 CONTACTIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3qt2 IL5RA structure of a cytokine ligand-receptor complex 2.55Å AUTH E.PATINO,A.KOTZSCH,S.SAREMBA,J.NICKEL,W.SCHMITZ,W.SEBALD,AUTH 2 T.D.MUELLERTITL STRUCTURE ANALYSIS OF THE IL-5 LIGAND-RECEPTOR COMPLEXTITL 2 REVEALS A WRENCH-LIKE ARCHITECTURE FOR IL-5RALPHA.REF STRUCTURE V. 19 1864 2011REFN ISSN 0969-2126PMID 22153509DOI 10.1016/J.STR.2011.08.015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ee5 ARHGAP5 solution structure of the n-teruminus extended rhogap domain from human rho gtpase activating protein 5 variant -1.0Å AUTH T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERUMINUS EXTENDEDTITL 2 RHOGAP DOMAIN FROM HUMAN RHO GTPASE ACTIVATINGTITL 3 PROTEIN 5 VARIANTREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants