Assessment of Structural Intolerance and Durability
General Structure Information 2c0l SCP2 tpr domain of human pex5p in complex with human mscp2 2.3Å AUTH W.A.STANLEY,F.V.FILIPP,P.KURSULA,N.SCHULLER,AUTH 2 R.ERDMANN,W.SCHLIEBS,M.SATTLER,M.WILMANNSTITL RECOGNITION OF A FUNCTIONAL PEROXISOME TYPE 1TITL 2 TARGET BY THE DYNAMIC IMPORT RECEPTOR PEX5P.REF MOL.CELL V. 24 653 2006REFN ISSN 1097-2765PMID 17157249DOI 10.1016/J.MOLCEL.2006.10.024 Variant Set Distributions Mapped Variants
General Structure Information 3qtz CDK2 cdk2 in complex with inhibitor rc-2-36 2.0Å AUTH E.SCHONBRUNN,S.BETZI,R.ALAM,M.P.MARTIN,A.BECKER,H.HAN,AUTH 2 R.FRANCIS,R.CHAKRASALI,S.JAKKARAJ,A.KAZI,S.M.SEBTI,AUTH 3 C.L.CUBITT,A.W.GEBHARD,L.A.HAZLEHURST,J.S.TASH,G.I.GEORGTITL DEVELOPMENT OF HIGHLY POTENT AND SELECTIVE DIAMINOTHIAZOLETITL 2 INHIBITORS OF CYCLIN-DEPENDENT KINASES.REF J.MED.CHEM. V. 56 3768 2013REFN ISSN 0022-2623PMID 23600925DOI 10.1021/JM301234K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2v5y PTPRM crystal structure of the receptor protein tyrosine phosphatase mu ectodomain 3.1Å AUTH A.R.ARICESCU,C.SIEBOLD,K.CHOUDHURI,V.T.CHANG,W.LU,S.J.DAVIS,AUTH 2 P.A.VAN DER MERWE,E.Y.JONESTITL STRUCTURE OF A TYROSINE PHOSPHATASE ADHESIVE INTERACTIONTITL 2 REVEALS A SPACER-CLAMP MECHANISM.REF SCIENCE V. 317 1217 2007REFN ISSN 0036-8075PMID 17761881DOI 10.1126/SCIENCE.1144646 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2r83 SYT1 crystal structure analysis of human synaptotagmin 1 c2a-c2b 2.7Å AUTH K.L.FUSON,M.MONTES,J.J.ROBERT,R.B.SUTTONTITL STRUCTURE OF HUMAN SYNAPTOTAGMIN 1 C2AB IN THETITL 2 ABSENCE OF CA2+ REVEALS A NOVEL DOMAIN ASSOCIATION.REF BIOCHEMISTRY V. 46 13041 2007REFN ISSN 0006-2960PMID 17956130DOI 10.1021/BI701651K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4c6f CAD crystal structure of the dihydroorotase domain of human cad bound to substrate at ph 6.5 1.26Å AUTH A.GRANDE-GARCIA,N.LALLOUS,C.DIAZ-TEJADA,S.RAMON-MAIQUESTITL STRUCTURE, FUNCTIONAL CHARACTERIZATION AND EVOLUTION OF THETITL 2 DIHYDROOROTASE DOMAIN OF HUMAN CAD.REF STRUCTURE V. 22 185 2014REFN ISSN 0969-2126PMID 24332717DOI 10.1016/J.STR.2013.10.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1t7y AZGP1 zn-alpha-2-glycoprotein; baculo-zag peg 200, no glycerol 2.8Å AUTH S.L.DELKER,A.P.WEST JR.,L.MCDERMOTT,M.W.KENNEDY,P.J.BJORKMANTITL CRYSTALLOGRAPHIC STUDIES OF LIGAND BINDING BYTITL 2 ZN-ALPHA2-GLYCOPROTEIN.REF J.STRUCT.BIOL. V. 148 205 2004REFN ISSN 1047-8477PMID 15477100DOI 10.1016/J.JSB.2004.04.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ksa TACR1 substance p in dmpc/chaps isotropic q=0.25 bicelles as a ligand for nk1r -1.0Å AUTH A.GAYEN,S.K.GOSWAMI,C.MUKHOPADHYAYTITL NMR EVIDENCE OF GM1-INDUCED CONFORMATIONAL CHANGE OFTITL 2 SUBSTANCE P USING ISOTROPIC BICELLESREF BIOCHIM.BIOPHYS.ACTA 2010REFN ISSN 0006-3002PMID 20937248DOI 10.1016/J.BBAMEM.2010.09.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2z6w PPIF crystal structure of human cyclophilin d in complex with cyclosporin a 0.96Å AUTH K.KAJITANI,M.FUJIHASHI,Y.KOBAYASHI,S.SHIMIZU,Y.TSUJIMOTO,AUTH 2 K.MIKITITL CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN D IN COMPLEX WITH ITSTITL 2 INHIBITOR, CYCLOSPORIN A AT 0.96-A RESOLUTION.REF PROTEINS V. 70 1635 2008REFN ISSN 0887-3585PMID 18076075DOI 10.1002/PROT.21855 Variant Set Distributions Mapped Variants
General Structure Information 1b4f EPHB2 oligomeric structure of the human ephb2 receptor sam domain 1.95Å AUTH C.D.THANOS,K.E.GOODWILL,J.U.BOWIETITL OLIGOMERIC STRUCTURE OF THE HUMAN EPHB2 RECEPTORTITL 2 SAM DOMAIN.REF SCIENCE V. 283 833 1999REFN ISSN 0036-8075PMID 9933164DOI 10.1126/SCIENCE.283.5403.833 Variant Set Distributions Mapped Variants
General Structure Information 2k7p FLNA filamin a ig-like domains 16-17 -1.0Å AUTH O.K.HEIKKINEN,S.RUSKAMO,P.V.KONAREV,D.I.SVERGUN,AUTH 2 T.IIVANAINEN,S.M.HEIKKINEN,P.PERMI,H.KOSKELA,AUTH 3 I.KILPELAINEN,J.YLANNETITL ATOMIC STRUCTURES OF TWO NOVEL IMMUNOGLOBULIN-LIKETITL 2 DOMAIN PAIRS IN THE ACTIN CROSS-LINKING PROTEINTITL 3 FILAMINREF J.BIOL.CHEM. V. 284 25450 2009REFN ISSN 0021-9258PMID 19622754DOI 10.1074/JBC.M109.019661 Variant Set Distributions Mapped Variants