General Structure Information 3bpr MERTK crystal structure of catalytic domain of the proto-oncogene tyrosine- protein kinase mer in complex with inhibitor c52 2.8Å AUTH X.HUANG,P.FINERTY,J.R.WALKER,C.BUTLER-COLE,M.VEDADI,AUTH 2 M.SCHAPIRA,S.A.PARKER,B.E.TURK,D.A.THOMPSON,S.DHE-PAGANONTITL STRUCTURAL INSIGHTS INTO THE INHIBITED STATES OF THE MERTITL 2 RECEPTOR TYROSINE KINASE.REF J.STRUCT.BIOL. V. 165 88 2009REFN ISSN 1047-8477PMID 19028587DOI 10.1016/J.JSB.2008.10.003 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2yuq ITK solution structure of the sh3 domain of human tyrosine- protein kinase itk/tsk -1.0Å AUTH H.ABE,K.MIYAMOTO,N.TOCHIO,M.SATO,S.KOSHIBA,AUTH 2 T.HARADA,S.WATANABE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF HUMANTITL 2 TYROSINE-PROTEIN KINASE ITK/TSKREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qkq EPHB4 structure of the sam domain of human ephrin type-b receptor 4 2.1Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL SAM DOMAIN OF HUMAN EPHRIN TYPE-B RECEPTOR 4TITL 2 (EPHB4)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3raw CLK3 crystal structure of human cdc-like kinase 3 isoform in complex with leucettine l41 2.09Å AUTH P.FILIPPAKOPOULOS,O.FEDOROV,O.KING,A.BULLOCK,J.R.C.MUNIZ,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 3 S.KNAPP,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN CDC-LIKE KINASE 3 ISOFORM WITH ATITL 2 BENZO-DIOXOL LIGANDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3p1i EPHB3 ligand binding domain of human ephrin type-b receptor 3 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,A.SEITOVA,J.KANIA,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL LIGAND BINDING DOMAIN OF HUMAN EPHB3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2djs EPHB1 solution structures of the fn3 domain of human ephrin type- b receptor 1 -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 EPHRIN TYPE-B RECEPTOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4et7 EPHA5 crystal structure of eph receptor 5 2.6Å AUTH J.H.SHI,W.L.ZHU,J.X.SONGTITL CRYSTAL STRUCTURE OF EPH RECEPTOR 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3enm MAP2K6 the structure of the map2k mek6 reveals an autoinhibitory dimer 2.35Å AUTH X.MIN,R.AKELLA,H.HE,J.M.HUMPHREYS,S.E.TSUTAKAWA,S.J.LEE,AUTH 2 J.A.TAINER,M.H.COBB,E.J.GOLDSMITHTITL THE STRUCTURE OF THE MAP2K MEK6 REVEALS AN AUTOINHIBITORYTITL 2 DIMERREF STRUCTURE V. 17 96 2009REFN ISSN 0969-2126PMID 19141286DOI 10.1016/J.STR.2008.11.007 Variant Set Distributions Mapped Variants
General Structure Information 2kk1 ABL2 solution structure of c-terminal domain of tyrosine-protein kinase abl2 from homo sapiens, northeast structural genomics consortium (nesg) target hr5537a -1.0Å AUTH G.LIU,Y.J.HUANG,R.XIAO,D.WANG,T.B.ACTON,AUTH 2 G.T.MONTELIONETITL NMR STRUCTURE OF F-ACTIN-BINDING DOMAIN OF ARG/ABL2TITL 2 FROM HOMO SAPIENS.REF PROTEINS V. 78 1326 2010REFN ISSN 0887-3585PMID 20077570DOI 10.1002/PROT.22656 Variant Set Distributions Mapped Variants
General Structure Information 3hmn TTK crystal structure of human mps1 catalytic domain in complex with atp 2.7Å AUTH M.L.CHU,Z.LANG,L.M.CHAVAS,J.NERES,O.S.FEDOROVA,L.TABERNERO,AUTH 2 M.CHERRY,D.H.WILLIAMS,K.T.DOUGLAS,P.A.EYERSTITL BIOPHYSICAL AND X-RAY CRYSTALLOGRAPHIC ANALYSIS OF MPS1TITL 2 KINASE INHIBITOR COMPLEXES.REF BIOCHEMISTRY V. 49 1689 2010REFN ISSN 0006-2960PMID 20099905DOI 10.1021/BI901970C Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]