Assessment of Structural Intolerance and Durability
General Structure Information 4iqm PUS1 crystal structure of the catalytic domain of human pus1 1.8Å AUTH N.CZUDNOCHOWSKI,A.L.WANG,J.FINER-MOORE,R.M.STROUDTITL IN HUMAN PSEUDOURIDINE SYNTHASE 1 (HPUS1), A C-TERMINALTITL 2 HELICAL INSERT BLOCKS TRNA FROM BINDING IN THE SAMETITL 3 ORIENTATION AS IN THE PUS1 BACTERIAL HOMOLOGUE TRUA,TITL 4 CONSISTENT WITH THEIR DIFFERENT TARGET SELECTIVITIES.REF J.MOL.BIOL. V. 425 3875 […]
General Structure Information 3ckk METTL1 crystal structure of human methyltransferase-like protein 1 1.55Å AUTH H.ZENG,A.DONG,E.DOBROVETSKY,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 3 H.WUTITL CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKE PROTEIN 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3zwf ELAC1 crystal structure of human trnase z, short form (elac1). 1.7Å AUTH C.K.ALLERSTON,T.KROJER,G.BERRIDGE,N.BURGESS-BROWN,AUTH 2 A.CHAIKUAD,R.CHALK,J.M.ELKINS,C.GILEADI,S.V.A.LATWIEL,AUTH 3 P.SAVITSKY,M.VOLLMAR,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 4 C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF HUMAN TRNASE Z, SHORT FORM (ELAC1).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ou5 TRNT1 crystal structure of human cca-adding enzyme 3.4Å AUTH M.A.AUGUSTIN,A.S.REICHERT,H.BETAT,R.HUBER,M.MOERL,AUTH 2 C.STEEGBORNTITL CRYSTAL STRUCTURE OF THE HUMAN CCA-ADDING ENZYME:TITL 2 INSIGHTS INTO TEMPLATE-INDEPENDENT POLYMERIZATIONREF J.MOL.BIOL. V. 328 985 2003REFN ISSN 0022-2836PMID 12729736DOI 10.1016/S0022-2836(03)00381-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3tht ALKBH8 crystal structure and rna binding properties of the rrm/alkb domains in human abh8, an enzyme catalyzing trna hypermodification, northeast structural genomics consortium target hr5601b 3.01Å AUTH C.PASTORE,I.TOPALIDOU,F.FOROUHAR,A.C.YAN,M.LEVY,J.F.HUNTTITL CRYSTAL STRUCTURE AND RNA BINDING PROPERTIES OF THE RNATITL 2 RECOGNITION MOTIF (RRM) AND ALKB DOMAINS IN HUMAN ALKBTITL 3 HOMOLOG 8 (ABH8), […]
General Structure Information 2gw6 TSEN15 nmr structure of the human trna endonuclease sen15 subunit -1.0Å AUTH J.SONG,J.L.MARKLEYTITL THREE-DIMENSIONAL STRUCTURE DETERMINED FOR ATITL 2 SUBUNIT OF HUMAN TRNA SPLICING ENDONUCLEASETITL 3 (SEN15) REVEALS A NOVEL DIMERIC FOLD.REF J.MOL.BIOL. V. 366 155 2007REFN ISSN 0022-2836PMID 17166513DOI 10.1016/J.JMB.2006.11.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3dh1 ADAT2 crystal structure of human trna-specific adenosine-34 deaminase subunit adat2 2.8Å AUTH M.WELIN,L.TRESAUGUES,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,T.NYMAN,K.OLESEN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,A.G.THORSELL,S.VAN DER BERG,AUTH 6 M.WISNIEWSKA,M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN TRNA-SPECIFIC ADENOSINE-34TITL 2 DEAMINASE SUBUNIT ADAT2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2okv DTD1 c-myc dna unwinding element binding protein 2.0Å AUTH M.KEMP,B.BAE,J.P.YU,M.GHOSH,M.LEFFAK,S.K.NAIRTITL STRUCTURE AND FUNCTION OF THE C-MYC DNA-UNWINDINGTITL 2 ELEMENT-BINDING PROTEIN DUE-B.REF J.BIOL.CHEM. V. 282 10441 2007REFN ISSN 0021-9258PMID 17264083DOI 10.1074/JBC.M609632200 Variant Set Distributions Mapped Variants
General Structure Information 4dpg KARS crystal structure of human lysrs: p38/aimp2 complex i 2.84Å AUTH Y.OFIR-BIRIN,P.FANG,S.P.BENNETT,H.M.ZHANG,J.WANG,I.RACHMIN,AUTH 2 R.SHAPIRO,J.SONG,A.DAGAN,J.POZO,S.KIM,A.G.MARSHALL,AUTH 3 P.SCHIMMEL,X.L.YANG,H.NECHUSHTAN,E.RAZIN,M.GUOTITL STRUCTURAL SWITCH OF LYSYL-TRNA SYNTHETASE BETWEENTITL 2 TRANSLATION AND TRANSCRIPTION.REF MOL.CELL V. 49 30 2013REFN ISSN 1097-2765PMID 23159739DOI 10.1016/J.MOLCEL.2012.10.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dpg KARS crystal structure of human lysrs: p38/aimp2 complex i 2.84Å AUTH Y.OFIR-BIRIN,P.FANG,S.P.BENNETT,H.M.ZHANG,J.WANG,I.RACHMIN,AUTH 2 R.SHAPIRO,J.SONG,A.DAGAN,J.POZO,S.KIM,A.G.MARSHALL,AUTH 3 P.SCHIMMEL,X.L.YANG,H.NECHUSHTAN,E.RAZIN,M.GUOTITL STRUCTURAL SWITCH OF LYSYL-TRNA SYNTHETASE BETWEENTITL 2 TRANSLATION AND TRANSCRIPTION.REF MOL.CELL V. 49 30 2013REFN ISSN 1097-2765PMID 23159739DOI 10.1016/J.MOLCEL.2012.10.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants