Assessment of Structural Intolerance and Durability
General Structure Information 3pta DNMT1 crystal structure of human dnmt1(646-1600) in complex with dna 3.6Å AUTH J.SONG,O.RECHKOBLIT,T.H.BESTOR,D.J.PATELTITL STRUCTURE OF DNMT1-DNA COMPLEX REVEALS A ROLE FORTITL 2 AUTOINHIBITION IN MAINTENANCE DNA METHYLATION.REF SCIENCE V. 331 1036 2011REFN ISSN 0036-8075PMID 21163962DOI 10.1126/SCIENCE.1195380 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dqy PARP1 structure of human parp-1 bound to a dna double strand break 3.25Å AUTH M.F.LANGELIER,J.L.PLANCK,S.ROY,J.M.PASCALTITL STRUCTURAL BASIS FOR DNA DAMAGE-DEPENDENTTITL 2 POLY(ADP-RIBOSYL)ATION BY HUMAN PARP-1.REF SCIENCE V. 336 728 2012REFN ISSN 0036-8075PMID 22582261DOI 10.1126/SCIENCE.1216338 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants