Assessment of Structural Intolerance and Durability
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2ytu FLI1 solution structure of the sam_pnt-domain of the human friend leukemiaintegration 1 transcription factor -1.0Å AUTH A.K.GORONCY,M.SATO,N.TOCHIO,S.KOSHIBA,S.WATANABE,AUTH 2 T.HARADA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM_PNT-DOMAIN OF THETITL 2 HUMAN FRIEND LEUKEMIAINTEGRATION 1 TRANSCRIPTIONTITL 3 FACTORREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4hzs TNK2 crystal structure of ack1 kinase domain with c-terminal sh3 domain 3.23Å AUTH K.S.GAJIWALA,K.MAEGLEY,R.FERRE,Y.A.HE,X.YUTITL ACK1: ACTIVATION AND REGULATION BY ALLOSTERY.REF PLOS ONE V. 8 53994 2013REFN ESSN 1932-6203PMID 23342057DOI 10.1371/JOURNAL.PONE.0053994 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1buo ZBTB16 btb domain from plzf 1.9Å AUTH K.F.AHMAD,C.K.ENGEL,G.G.PRIVETITL CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM PLZF.REF PROC.NATL.ACAD.SCI.USA V. 95 12123 1998REFN ISSN 0027-8424PMID 9770450DOI 10.1073/PNAS.95.21.12123 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3coa FOXO1 crystal structure of foxo1 dbd bound to ire dna 2.2Å AUTH M.M.BRENT,R.ANAND,R.MARMORSTEINTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY FOXO1 ANDTITL 2 ITS REGULATION BY POSTTRANSLATIONAL MODIFICATION.REF STRUCTURE V. 16 1407 2008REFN ISSN 0969-2126PMID 18786403DOI 10.1016/J.STR.2008.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lll LMNB2 solution nmr structure of c-terminal globular domain of human lamin- b2, northeast structural genomics consortium target hr8546a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,C.XU,J.MIN,AUTH 2 G.T.MONTELIONE,C.ARROWSMITHTITL NMR SOLUTION STRUCTURE OF C-TERMINAL GLOBULAR DOMAIN OFTITL 2 HUMAN LAMIN-B2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lll LMNB2 solution nmr structure of c-terminal globular domain of human lamin- b2, northeast structural genomics consortium target hr8546a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,C.XU,J.MIN,AUTH 2 G.T.MONTELIONE,C.ARROWSMITHTITL NMR SOLUTION STRUCTURE OF C-TERMINAL GLOBULAR DOMAIN OFTITL 2 HUMAN LAMIN-B2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lll LMNB2 solution nmr structure of c-terminal globular domain of human lamin- b2, northeast structural genomics consortium target hr8546a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,C.XU,J.MIN,AUTH 2 G.T.MONTELIONE,C.ARROWSMITHTITL NMR SOLUTION STRUCTURE OF C-TERMINAL GLOBULAR DOMAIN OFTITL 2 HUMAN LAMIN-B2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants