Assessment of Structural Intolerance and Durability
General Structure Information 1j8e LRP1 crystal structure of ligand-binding repeat cr7 from lrp 1.85Å AUTH M.SIMONOVIC,K.DOLMER,W.HUANG,D.K.STRICKLAND,K.VOLZ,AUTH 2 P.G.GETTINSTITL CALCIUM COORDINATION AND PH DEPENDENCE OF THETITL 2 CALCIUM AFFINITY OF LIGAND-BINDING REPEAT CR7 FROMTITL 3 THE LRP. COMPARISON WITH RELATED DOMAINS FROM THETITL 4 LRP AND THE LDL RECEPTOR.REF BIOCHEMISTRY V. 40 15127 2001REFN ISSN 0006-2960PMID […]
General Structure Information 1qsc TRAF2 crystal structure of the traf domain of traf2 in a complex with a peptide from the cd40 receptor 2.4Å AUTH S.M.MCWHIRTER,S.S.PULLEN,J.M.HOLTON,J.J.CRUTE,AUTH 2 M.R.KEHRY,T.ALBERTITL CRYSTALLOGRAPHIC ANALYSIS OF CD40 RECOGNITION ANDTITL 2 SIGNALING BY HUMAN TRAF2.REF PROC.NATL.ACAD.SCI.USA V. 96 8408 1999REFN ISSN 0027-8424PMID 10411888DOI 10.1073/PNAS.96.15.8408 Variant Set Distributions Mapped Variants
General Structure Information 1e8i CD69 human cd69 – tetragonal form 1.95Å AUTH A.S.LLERA,F.VIEDMA,F.SANCHEZ-MADRID,J.TORMOTITL CRYSTAL STRUCTURE OF THE C-TYPE LECTIN-LIKE DOMAINTITL 2 FROM THE HUMAN HEMATOPOIETIC CELL RECEPTOR CD69REF J.BIOL.CHEM. V. 276 7312 2001REFN ISSN 0021-9258PMID 11036086DOI 10.1074/JBC.M008573200 Variant Set Distributions Mapped Variants
General Structure Information 1zdt NR5A1 the crystal structure of human steroidogenic factor-1 2.1Å AUTH W.WANG,C.ZHANG,A.MARIMUTHU,H.I.KRUPKA,M.TABRIZIZAD,AUTH 2 R.SHELLOE,U.MEHRA,K.ENG,H.NGUYEN,C.SETTACHATGUL,B.POWELL,AUTH 3 M.V.MILBURN,B.L.WESTTITL THE CRYSTAL STRUCTURES OF HUMAN STEROIDOGENIC FACTOR-1 ANDTITL 2 LIVER RECEPTOR HOMOLOGUE-1REF PROC.NATL.ACAD.SCI.USA V. 102 7505 2005REFN ISSN 0027-8424PMID 15897460DOI 10.1073/PNAS.0409482102 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ks9 GRM1 metabotropic glutamate receptor mglur1 complexed with ly341495 antagonist 1.9Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR1 COMPLEXED WITHTITL 2 LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1kzz TRAF3 downstream regulator tank binds to the cd40 recognition site on traf3 3.5Å AUTH C.LI,C.Z.NI,M.L.HAVERT,E.CABEZAS,J.HE,D.KAISER,AUTH 2 J.C.REED,A.C.SATTERTHWAIT,G.CHENG,K.R.ELYTITL DOWNSTREAM REGULATOR TANK BINDS TO THE CD40TITL 2 RECOGNITION SITE ON TRAF3.REF STRUCTURE V. 10 403 2002REFN ISSN 0969-2126PMID 12005438DOI 10.1016/S0969-2126(02)00733-5 Variant Set Distributions Mapped Variants
General Structure Information 4k0v TEK structural basis for angiopoietin-1 mediated signaling initiation 4.51Å AUTH X.YU,T.C.SEEGAR,A.C.DALTON,D.TZVETKOVA-ROBEV,Y.GOLDGUR,AUTH 2 K.R.RAJASHANKAR,D.B.NIKOLOV,W.A.BARTONTITL STRUCTURAL BASIS FOR ANGIOPOIETIN-1-MEDIATED SIGNALINGTITL 2 INITIATION.REF PROC.NATL.ACAD.SCI.USA V. 110 7205 2013REFN ISSN 0027-8424PMID 23592718DOI 10.1073/PNAS.1216890110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dbj MERTK solution structures of the fn3 domain of human proto- oncogene tyrosine-protein kinase mer precursor -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MERTITL 3 PRECURSORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2jjs CD47 structure of human cd47 in complex with human signal regulatory protein (sirp) alpha 1.85Å AUTH D.HATHERLEY,S.C.GRAHAM,J.TURNER,K.HARLOS,AUTH 2 D.I.STUART,A.N.BARCLAYTITL PAIRED RECEPTOR SPECIFICITY EXPLAINED BYTITL 2 STRUCTURES OF SIGNAL REGULATORY PROTEINS ALONE ANDTITL 3 COMPLEXED WITH CD47.REF MOL.CELL V. 31 266 2008REFN ISSN 1097-2765PMID 18657508DOI 10.1016/J.MOLCEL.2008.05.026 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4n0f FCGRT human fcrn complexed with human serum albumin 3.02Å AUTH V.OGANESYAN,M.M.DAMSCHRODER,K.E.COOK,Q.LI,C.GAO,H.WU,AUTH 2 W.F.DALLACQUATITL STRUCTURAL INSIGHTS INTO NEONATAL FC RECEPTOR-BASEDTITL 2 RECYCLING MECHANISMS.REF J.BIOL.CHEM. V. 289 7812 2014REFN ISSN 0021-9258PMID 24469444DOI 10.1074/JBC.M113.537563 Variant Set Distributions Mapped Variants