Assessment of Structural Intolerance and Durability
General Structure Information 4ewi NLRP4 crystal structure of the nlrp4 pyrin domain 2.28Å AUTH C.EIBL,S.GRIGORIU,M.HESSENBERGER,J.WENGER,S.PUEHRINGER,AUTH 2 A.S.PINHEIRO,R.N.WAGNER,M.PROELL,J.C.REED,R.PAGE,AUTH 3 K.DIEDERICHS,W.PETITITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE NLRP4 PYRINTITL 2 DOMAIN.REF BIOCHEMISTRY V. 51 7330 2012REFN ISSN 0006-2960PMID 22928810DOI 10.1021/BI3007059 Variant Set Distributions Mapped Variants
General Structure Information 2km6 NLRP7 nmr structure of the nlrp7 pyrin domain -1.0Å AUTH A.S.PINHEIRO,M.PROELL,C.EIBL,R.PAGE,R.SCHWARZENBACHER,W.PETITITL THREE-DIMENSIONAL STRUCTURE OF THE NLRP7 PYRIN DOMAIN:TITL 2 INSIGHT INTO PYRIN-PYRIN-MEDIATED EFFECTOR DOMAIN SIGNALINGTITL 3 IN INNATE IMMUNITY.REF J.BIOL.CHEM. V. 285 27402 2010REFN ISSN 0021-9258PMID 20547486DOI 10.1074/JBC.M110.113191 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2hm2 PYDC1 solution structure of asc2 -1.0Å AUTH A.NATARAJAN,R.GHOSE,J.M.HILLTITL STRUCTURE AND DYNAMICS OF ASC2, A PYRINTITL 2 DOMAIN-ONLY PROTEIN THAT REGULATES INFLAMMATORYTITL 3 SIGNALINGREF J.BIOL.CHEM. V. 281 31863 2006REFN ISSN 0021-9258PMID 16905547DOI 10.1074/JBC.M605458200 Variant Set Distributions Mapped Variants
General Structure Information 2m5v NLRP10 three-dimensional structure of human nlrp10/pynod pyrin domain -1.0Å AUTH M.Y.SU,C.I.KUO,C.F.CHANG,C.I.CHANGTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN NLRP10/PYNOD PYRINTITL 2 DOMAIN REVEALS A HOMOTYPIC INTERACTION SITE DISTINCT FROMTITL 3 ITS MOUSE HOMOLOGUE.REF PLOS ONE V. 8 67843 2013REFN ESSN 1932-6203PMID 23861819DOI 10.1371/JOURNAL.PONE.0067843 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2l6a NLRP12 three-dimensional structure of the n-terminal effector pyrin domain of nlrp12 -1.0Å AUTH A.S.PINHEIRO,C.EIBL,Z.EKMAN-VURAL,R.SCHWARZENBACHER,W.PETITITL THE NLRP12 PYRIN DOMAIN: STRUCTURE, DYNAMICS, AND FUNCTIONALTITL 2 INSIGHTS.REF J.MOL.BIOL. V. 413 790 2011REFN ISSN 0022-2836PMID 21978668DOI 10.1016/J.JMB.2011.09.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l6a NLRP12 three-dimensional structure of the n-terminal effector pyrin domain of nlrp12 -1.0Å AUTH A.S.PINHEIRO,C.EIBL,Z.EKMAN-VURAL,R.SCHWARZENBACHER,W.PETITITL THE NLRP12 PYRIN DOMAIN: STRUCTURE, DYNAMICS, AND FUNCTIONALTITL 2 INSIGHTS.REF J.MOL.BIOL. V. 413 790 2011REFN ISSN 0022-2836PMID 21978668DOI 10.1016/J.JMB.2011.09.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants