Assessment of Structural Intolerance and Durability
General Structure Information 3le4 DGCR8 crystal structure of the dgcr8 dimerization domain 1.7Å AUTH R.SENTURIA,M.FALLER,S.YIN,J.A.LOO,D.CASCIO,M.R.SAWAYA,AUTH 2 D.HWANG,R.T.CLUBB,F.GUOTITL STRUCTURE OF THE DIMERIZATION DOMAIN OF DIGEORGE CRITICALTITL 2 REGION 8REF PROTEIN SCI. V. 19 1354 2010REFN ISSN 0961-8368PMID 20506313DOI 10.1002/PRO.414 Variant Set Distributions Mapped Variants
General Structure Information 3dh1 ADAT2 crystal structure of human trna-specific adenosine-34 deaminase subunit adat2 2.8Å AUTH M.WELIN,L.TRESAUGUES,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,T.NYMAN,K.OLESEN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,A.G.THORSELL,S.VAN DER BERG,AUTH 6 M.WISNIEWSKA,M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN TRNA-SPECIFIC ADENOSINE-34TITL 2 DEAMINASE SUBUNIT ADAT2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3ztg RBBP6 solution structure of the ring finger-like domain of retinoblastoma binding protein-6 (rbbp6) -1.0Å AUTH M.A.KAPPO,E.AB,F.HASSEM,R.A.ATKINSON,A.FARO,V.MULEYA,AUTH 2 T.MULAUDZI,J.O.POOLE,J.M.MCKENZIE,M.CHIBI,J.C.MOOLMAN-SMOOK,AUTH 3 D.J.G.REES,D.J.R.PUGHTITL SOLUTION STRUCTURE OF THE RING FINGER-LIKE DOMAIN OFTITL 2 RETINOBLASTOMA BINDING PROTEIN-6 (RBBP6) SUGGESTS ITTITL 3 FUNCTIONS AS A U-BOXREF J.BIOL.CHEM. V. 287 7146 2012REFN ISSN 0021-9258PMID 22130672DOI 10.1074/JBC.M110.217059 Variant Set […]
General Structure Information 4ndg APTX human aprataxin (aptx) bound to rna-dna and zn – adenosine vanadate transition state mimic complex 2.54Å AUTH P.TUMBALE,J.S.WILLIAMS,M.J.SCHELLENBERG,T.A.KUNKEL,AUTH 2 R.S.WILLIAMSTITL APRATAXIN RESOLVES ADENYLATED RNA-DNA JUNCTIONS TO MAINTAINTITL 2 GENOME INTEGRITY.REF NATURE V. 506 111 2013REFN ISSN 0028-0836PMID 24362567DOI 10.1038/NATURE12824 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3q2t CPSF6 crystal structure of cfim68 rrm/cfim25/rna complex 3.06Å AUTH Q.YANG,M.COSENO,G.M.GILMARTIN,S.DOUBLIETITL CRYSTAL STRUCTURE OF A HUMAN CLEAVAGE FACTORTITL 2 CFI(M)25/CFI(M)68/RNA COMPLEX PROVIDES AN INSIGHT INTOTITL 3 POLY(A) SITE RECOGNITION AND RNA LOOPING.REF STRUCTURE V. 19 368 2011REFN ISSN 0969-2126PMID 21295486DOI 10.1016/J.STR.2010.12.021 Variant Set Distributions Mapped Variants
General Structure Information 3e9l PRPF8 crystal structure of human prp8, residues 1755-2016 1.95Å AUTH V.PENA,A.ROZOV,P.FABRIZIO,R.LUHRMANN,M.C.WAHLTITL STRUCTURE AND FUNCTION OF AN RNASE H DOMAIN AT THE HEART OFTITL 2 THE SPLICEOSOME.REF EMBO J. V. 27 2929 2008REFN ISSN 0261-4189PMID 18843295DOI 10.1038/EMBOJ.2008.209 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3i4u DHX8 crystal structure analysis of a helicase associated domain 2.1Å AUTH D.KUDLINZKI,A.SCHMITT,H.CHRISTIAN,R.FICNERTITL STRUCTURAL ANALYSIS OF THE C-TERMINAL DOMAIN OF THETITL 2 SPLICEOSOMAL HELICASE PRP22REF BIOL.CHEM. V. 393 1131 2012REFN ISSN 1431-6730PMID 23096351DOI 10.1515/HSZ-2012-0158 Variant Set Distributions Mapped Variants
General Structure Information 4a8x RNPS1 structure of the core asap complex 1.9Å AUTH A.G.MURACHELLI,J.EBERT,C.BASQUIN,H.LE HIR,E.CONTITITL THE STRUCTURE OF THE ASAP CORE COMPLEX REVEALS THETITL 2 EXISTENCE OF A PININ-CONTAINING PSAP COMPLEXREF NAT.STRUCT.MOL.BIOL. V. 19 378 2012REFN ISSN 1545-9993PMID 22388736DOI 10.1038/NSMB.2242 Variant Set Distributions Mapped Variants
General Structure Information 2x7g SRPK2 structure of human serine-arginine-rich protein-specific kinase 2 (srpk2) bound to purvalanol b 2.5Å AUTH A.C.W.PIKE,P.SAVITSKY,O.FEDOROV,T.KROJER,E.UGOCHUKWU,AUTH 2 F.VON DELFT,O.GILEADI,A.EDWARDS,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 C.BOUNTRA,S.KNAPPTITL STRUCTURE OF HUMAN SERINE-ARGININE-RICH PROTEIN- SPECIFICTITL 2 KINASE 2 (SRPK2) BOUND TO PURVALANOL BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ex7 MAGOH the crystal structure of ejc in its transition state 2.3Å AUTH K.H.NIELSEN,H.CHAMIEH,C.B.ANDERSEN,F.FREDSLUND,AUTH 2 K.HAMBORG,H.LE HIR,G.R.ANDERSENTITL MECHANISM OF ATP TURNOVER INHIBITION IN THE EJCREF RNA V. 15 67 2009REFN ISSN 1355-8382PMID 19033377DOI 10.1261/RNA.1283109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants