Assessment of Structural Intolerance and Durability
General Structure Information 3cw1 SNRNP70 crystal structure of human spliceosomal u1 snrnp 5.49Å AUTH D.A.POMERANZ KRUMMEL,C.OUBRIDGE,A.K.LEUNG,J.LI,K.NAGAITITL CRYSTAL STRUCTURE OF HUMAN SPLICEOSOMAL U1 SNRNP AT 5.5 ATITL 2 RESOLUTION.REF NATURE V. 458 475 2009REFN ISSN 0028-0836PMID 19325628DOI 10.1038/NATURE07851 Variant Set Distributions Mapped Variants
General Structure Information 4f91 SNRNP200 brr2 helicase region 2.7Å AUTH K.F.SANTOS,S.M.JOVIN,G.WEBER,V.PENA,R.LUHRMANN,M.C.WAHLTITL STRUCTURAL BASIS FOR FUNCTIONAL COOPERATION BETWEEN TANDEMTITL 2 HELICASE CASSETTES IN BRR2-MEDIATED REMODELING OF THETITL 3 SPLICEOSOME.REF PROC.NATL.ACAD.SCI.USA V. 109 17418 2012REFN ISSN 0027-8424PMID 23045696DOI 10.1073/PNAS.1208098109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3s6n GEMIN2 crystal structure of the gemin2-binding domain of smn, gemin2 in complex with smd1/d2/f/e/g from human 2.5Å AUTH R.ZHANG,B.R.SO,P.LI,J.YONG,T.GLISOVIC,L.WAN,G.DREYFUSSTITL STRUCTURE OF A KEY INTERMEDIATE OF THE SMN COMPLEX REVEALSTITL 2 GEMIN2S CRUCIAL FUNCTION IN SNRNP ASSEMBLY.REF CELL(CAMBRIDGE,MASS.) V. 146 384 2011REFN ISSN 0092-8674PMID 21816274DOI 10.1016/J.CELL.2011.06.043 Variant Set Distributions Mapped Variants