Assessment of Structural Intolerance and Durability
General Structure Information 3ews DDX19B human dead-box rna-helicase ddx19 in complex with adp 2.7Å AUTH R.COLLINS,T.KARLBERG,L.LEHTIO,P.SCHUTZ,AUTH 2 S.VAN DEN BERG,L.G.DAHLGREN,M.HAMMARSTROM,AUTH 3 J.WEIGELT,H.SCHULERTITL THE DEXD/H-BOX RNA HELICASE DDX19 IS REGULATED BYTITL 2 AN {ALPHA}-HELICAL SWITCH.REF J.BIOL.CHEM. V. 284 10296 2009REFN ISSN 0021-9258PMID 19244245DOI 10.1074/JBC.C900018200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3i4r NUP133 nup107(aa658-925)/nup133(aa517-1156) complex, h.sapiens 3.53Å AUTH J.R.WHITTLE,T.U.SCHWARTZTITL ARCHITECTURAL NUCLEOPORINS NUP157/170 AND NUP133TITL 2 ARE STRUCTURALLY RELATED AND DESCEND FROM A SECONDTITL 3 ANCESTRAL ELEMENT.REF J.BIOL.CHEM. V. 284 28442 2009REFN ISSN 0021-9258PMID 19674973DOI 10.1074/JBC.M109.023580 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3mmy RAE1 structural and functional analysis of the interaction between the nucleoporin nup98 and the mrna export factor rae1 1.65Å AUTH Y.REN,H.S.SEO,G.BLOBEL,A.HOELZTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE INTERACTIONTITL 2 BETWEEN THE NUCLEOPORIN NUP98 AND THE MRNA EXPORT FACTORTITL 3 RAE1.REF PROC.NATL.ACAD.SCI.USA V. 107 10406 2010REFN ISSN 0027-8424PMID 20498086DOI 10.1073/PNAS.1005389107 Variant Set […]
General Structure Information 3bg0 SEC13 architecture of a coat for the nuclear pore membrane 3.15Å AUTH K.C.HSIA,P.STAVROPOULOS,G.BLOBEL,A.HOELZTITL ARCHITECTURE OF A COAT FOR THE NUCLEAR PORETITL 2 MEMBRANE.REF CELL(CAMBRIDGE,MASS.) V. 131 1313 2007REFN ISSN 0092-8674PMID 18160040DOI 10.1016/J.CELL.2007.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3i4r NUP107 nup107(aa658-925)/nup133(aa517-1156) complex, h.sapiens 3.53Å AUTH J.R.WHITTLE,T.U.SCHWARTZTITL ARCHITECTURAL NUCLEOPORINS NUP157/170 AND NUP133TITL 2 ARE STRUCTURALLY RELATED AND DESCEND FROM A SECONDTITL 3 ANCESTRAL ELEMENT.REF J.BIOL.CHEM. V. 284 28442 2009REFN ISSN 0021-9258PMID 19674973DOI 10.1074/JBC.M109.023580 Variant Set Distributions Mapped Variants
General Structure Information 3mmy RAE1 structural and functional analysis of the interaction between the nucleoporin nup98 and the mrna export factor rae1 1.65Å AUTH Y.REN,H.S.SEO,G.BLOBEL,A.HOELZTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE INTERACTIONTITL 2 BETWEEN THE NUCLEOPORIN NUP98 AND THE MRNA EXPORT FACTORTITL 3 RAE1.REF PROC.NATL.ACAD.SCI.USA V. 107 10406 2010REFN ISSN 0027-8424PMID 20498086DOI 10.1073/PNAS.1005389107 Variant Set […]
General Structure Information 3bg0 SEC13 architecture of a coat for the nuclear pore membrane 3.15Å AUTH K.C.HSIA,P.STAVROPOULOS,G.BLOBEL,A.HOELZTITL ARCHITECTURE OF A COAT FOR THE NUCLEAR PORETITL 2 MEMBRANE.REF CELL(CAMBRIDGE,MASS.) V. 131 1313 2007REFN ISSN 0092-8674PMID 18160040DOI 10.1016/J.CELL.2007.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3i4r NUP107 nup107(aa658-925)/nup133(aa517-1156) complex, h.sapiens 3.53Å AUTH J.R.WHITTLE,T.U.SCHWARTZTITL ARCHITECTURAL NUCLEOPORINS NUP157/170 AND NUP133TITL 2 ARE STRUCTURALLY RELATED AND DESCEND FROM A SECONDTITL 3 ANCESTRAL ELEMENT.REF J.BIOL.CHEM. V. 284 28442 2009REFN ISSN 0021-9258PMID 19674973DOI 10.1074/JBC.M109.023580 Variant Set Distributions Mapped Variants
General Structure Information 3uio RANBP2 complex between human rangap1-sumo2, ubc9 and the ir1 domain from ranbp2 containing ir2 motif ii 2.6Å AUTH J.R.GAREAU,D.REVERTER,C.D.LIMATITL DETERMINANTS OF SMALL UBIQUITIN-LIKE MODIFIER 1 (SUMO1)TITL 2 PROTEIN SPECIFICITY, E3 LIGASE, AND SUMO-RANGAP1 BINDINGTITL 3 ACTIVITIES OF NUCLEOPORIN RANBP2.REF J.BIOL.CHEM. V. 287 4740 2012REFN ISSN 0021-9258PMID 22194619DOI 10.1074/JBC.M111.321141 Variant Set Distributions […]
General Structure Information 1ko6 NUP98 crystal structure of c-terminal autoproteolytic domain of nucleoporin nup98 3.0Å AUTH A.E.HODEL,M.R.HODEL,E.R.GRIFFIS,K.A.HENNIG,AUTH 2 G.A.RATNER,S.XU,M.A.POWERSTITL THE THREE-DIMENSIONAL STRUCTURE OF THETITL 2 AUTOPROTEOLYTIC, NUCLEAR PORE-TARGETING DOMAIN OFTITL 3 THE HUMAN NUCLEOPORIN NUP98.REF MOL.CELL V. 10 347 2002REFN ISSN 1097-2765PMID 12191480DOI 10.1016/S1097-2765(02)00589-0 Variant Set Distributions Mapped Variants