Assessment of Structural Intolerance and Durability
General Structure Information 3bpu MAGI1 crystal structure of the 3rd pdz domain of human membrane associated guanylate kinase, c677s and c709s double mutant 1.6Å AUTH E.S.PILKA,V.HOZJAN,C.COOPER,A.C.W.PIKE,J.ELKINS,D.A.DOYLE,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF HUMAN MEMBRANETITL 2 ASSOCIATED GUANYLATE KINASE, C677S AND C709S DOUBLE MUTANT.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 2kpk MAGI1 magi-1 pdz1 -1.0Å AUTH S.CHARBONNIER,Y.NOMINE,J.RAMIREZ,K.LUCK,A.CHAPELLE,AUTH 2 R.H.STOTE,G.TRAVE,B.KIEFFER,R.A.ATKINSONTITL THE STRUCTURAL AND DYNAMIC RESPONSE OF MAGI-1 PDZ1 WITHTITL 2 NON-CANONICAL DOMAIN BOUNDARIES TO BINDING OF HUMANTITL 3 PAPILLOMAVIRUS (HPV) E6REF J.MOL.BIOL. 2011REFN ESSN 1089-8638PMID 21238461DOI 10.1016/J.JMB.2011.01.015 Variant Set Distributions Mapped Variants
General Structure Information 2r4h MAGI1 crystal structure of a c1190s mutant of the 6th pdz domain of human membrane associated guanylate kinase 2.05Å AUTH E.UGOCHUKWU,E.S.PILKA,V.HOZJAN,K.L.KAVANAGH,C.COOPER,AUTH 2 A.C.W.PIKE,J.M.ELKINS,D.A.DOYLE,F.VON DELFT,M.SUNDSTROM,AUTH 3 C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF A C1190S MUTANT OF THE 6TH PDZ DOMAINTITL 2 OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s […]
General Structure Information 2q9v MAGI1 crystal structure of the c890s mutant of the 4th pdz domain of human membrane associated guanylate kinase 2.0Å AUTH E.S.PILKA,V.HOZJAN,K.L.KAVANAGH,E.PAPAGRIGORIOU,C.COOPER,AUTH 2 J.M.ELKINS,D.A.DOYLE,F.VON DELFT,M.SUNDSTROM,C.A.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE C890S MUTANT OF THE 4TH PDZ DOMAINTITL 2 OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 2h3l ERBB2IP crystal structure of erbin pdz 1.0Å AUTH B.A.APPLETON,Y.ZHANG,P.WU,J.P.YIN,W.HUNZIKER,AUTH 2 N.J.SKELTON,S.S.SIDHU,C.WIESMANNTITL COMPARATIVE STRUCTURAL ANALYSIS OF THE ERBIN PDZTITL 2 DOMAIN AND THE FIRST PDZ DOMAIN OF ZO-1. INSIGHTSTITL 3 INTO DETERMINANTS OF PDZ DOMAIN SPECIFICITY.REF J.BIOL.CHEM. V. 281 22312 2006REFN ISSN 0021-9258PMID 16737969DOI 10.1074/JBC.M602901200 Variant Set Distributions Mapped Variants
General Structure Information 2i1n DLG3 crystal structure of the 1st pdz domain of human dlg3 1.85Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,C.PHILLIPS,AUTH 2 C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINED WITH THETITL 2 HELP OF SELF-BINDING C-TERMINAL EXTENSIONS.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 2pa1 PDLIM2 structure of the pdz domain of human pdlim2 bound to a c-terminal extension from human beta-tropomyosin 1.7Å AUTH J.UPPENBERG,L.SHRESTHA,J.ELKINS,N.BURGESS-BROWN,E.SALAH,AUTH 2 G.BUNKOCZI,E.PAPAGRIGORIOU,A.C.W.PIKE,A.P.TURNBULL,AUTH 3 E.UGOCHUKWU,C.UMEANO,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,AUTH 4 A.EDWARDS,M.SUNDSTROM,D.A.DOYLETITL STRUCTURE OF THE PDZ DOMAIN OF HUMAN PDLIM2 BOUND TO ATITL 2 C-TERMINAL EXTENSION FROM HUMAN BETA-TROPOMYOSIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 1um7 DLG3 solution structure of the third pdz domain of synapse- associated protein 102 -1.0Å AUTH X.-R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD PDZ DOMAIN OFTITL 2 SYNAPSE-ASSOCIATED PROTEIN 102REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1um1 RADIL solution structure of rsgi ruh-007, pdz domain in human cdna -1.0Å AUTH Y.DOI-KATAYAMA,F.HAYASHI,H.HIROTA,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-007, A PDZ DOMAINTITL 2 IN HUMAN CDNAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2uzc PDLIM5 structure of human pdlim5 in complex with the c-terminal peptide of human alpha-actinin-1 1.5Å AUTH J.M.ELKINS,C.GILEADI,L.SHRESTHA,C.PHILLIPS,J.WANG,AUTH 2 J.R.C.MUNIZ,D.A.DOYLETITL UNUSUAL BINDING INTERACTIONS IN PDZ DOMAIN CRYSTALTITL 2 STRUCTURES HELP EXPLAIN BINDING MECHANISMS.REF PROTEIN SCI. V. 19 731 2010REFN ISSN 0961-8368PMID 20120020DOI 10.1002/PRO.349 Variant Set Distributions Mapped Variants