Assessment of Structural Intolerance and Durability
General Structure Information 1kbh NCOA3 mutual synergistic folding in the interaction between nuclear receptor coactivators cbp and actr -1.0Å AUTH S.J.DEMAREST,M.MARTINEZ-YAMOUT,J.CHUNG,H.CHEN,W.XU,AUTH 2 H.J.DYSON,R.M.EVANS,P.E.WRIGHTTITL MUTUAL SYNERGISTIC FOLDING IN RECRUITMENT OFTITL 2 CBP/P300 BY P160 NUCLEAR RECEPTOR COACTIVATORS.REF NATURE V. 415 549 2002REFN ISSN 0028-0836PMID 11823864DOI 10.1038/415549A Variant Set Distributions Mapped Variants
General Structure Information 2xvs TTC5 crystal structure of human ttc5 (strap) c-terminal ob domain 1.8Å AUTH C.J.ADAMS,A.C.PIKE,S.MANIAM,T.D.SHARPE,A.S.COUTTS,S.KNAPP,AUTH 2 N.B.LA THANGUE,A.N.BULLOCKTITL THE P53 COFACTOR STRAP EXHIBITS AN UNEXPECTED TPR MOTIF ANDTITL 2 OLIGONUCLEOTIDE-BINDING (OB)-FOLD STRUCTURE.REF PROC.NATL.ACAD.SCI.USA V. 109 3778 2012REFN ISSN 0027-8424PMID 22362889DOI 10.1073/PNAS.1113731109 Variant Set Distributions Mapped Variants
General Structure Information 3io2 EP300 crystal structure of the taz2 domain of p300 2.5Å AUTH M.MILLER,Z.DAUTER,S.CHERRY,J.E.TROPEA,A.WLODAWERTITL STRUCTURE OF THE TAZ2 DOMAIN OF P300: INSIGHTS INTO LIGANDTITL 2 BINDING.REF ACTA CRYSTALLOGR.,SECT.D V. 65 1301 2009REFN ISSN 0907-4449PMID 19966416DOI 10.1107/S0907444909040153 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants