Assessment of Structural Intolerance and Durability
General Structure Information 2r3v MVK the biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism 2.5Å AUTH Z.FU,N.E.VOYNOVA,T.J.HERDENDORF,H.M.MIZIORKO,AUTH 2 J.J.KIMTITL BIOCHEMICAL AND STRUCTURAL BASIS FOR FEEDBACKTITL 2 INHIBITION OF MEVALONATE KINASE AND ISOPRENOIDTITL 3 METABOLISM.REF BIOCHEMISTRY V. 47 3715 2008REFN ISSN 0006-2960PMID 18302342DOI 10.1021/BI7024386 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2r3v MVK the biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism 2.5Å AUTH Z.FU,N.E.VOYNOVA,T.J.HERDENDORF,H.M.MIZIORKO,AUTH 2 J.J.KIMTITL BIOCHEMICAL AND STRUCTURAL BASIS FOR FEEDBACKTITL 2 INHIBITION OF MEVALONATE KINASE AND ISOPRENOIDTITL 3 METABOLISM.REF BIOCHEMISTRY V. 47 3715 2008REFN ISSN 0006-2960PMID 18302342DOI 10.1021/BI7024386 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2kij ATP7A solution structure of the actuator domain of the copper- transporting atpase atp7a -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,M.MIGLIARDI,G.NATILE,AUTH 2 F.NUSHI,A.ROSATOTITL SOLUTION STRUCTURES OF THE ACTUATOR DOMAIN OF ATP7ATITL 2 AND ATP7B, THE MENKES AND WILSON DISEASE PROTEINSREF BIOCHEMISTRY V. 48 7849 2009REFN ISSN 0006-2960PMID 19645496DOI 10.1021/BI901003K Variant Set Distributions Mapped Variants
General Structure Information 3io2 EP300 crystal structure of the taz2 domain of p300 2.5Å AUTH M.MILLER,Z.DAUTER,S.CHERRY,J.E.TROPEA,A.WLODAWERTITL STRUCTURE OF THE TAZ2 DOMAIN OF P300: INSIGHTS INTO LIGANDTITL 2 BINDING.REF ACTA CRYSTALLOGR.,SECT.D V. 65 1301 2009REFN ISSN 0907-4449PMID 19966416DOI 10.1107/S0907444909040153 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bpr MERTK crystal structure of catalytic domain of the proto-oncogene tyrosine- protein kinase mer in complex with inhibitor c52 2.8Å AUTH X.HUANG,P.FINERTY,J.R.WALKER,C.BUTLER-COLE,M.VEDADI,AUTH 2 M.SCHAPIRA,S.A.PARKER,B.E.TURK,D.A.THOMPSON,S.DHE-PAGANONTITL STRUCTURAL INSIGHTS INTO THE INHIBITED STATES OF THE MERTITL 2 RECEPTOR TYROSINE KINASE.REF J.STRUCT.BIOL. V. 165 88 2009REFN ISSN 1047-8477PMID 19028587DOI 10.1016/J.JSB.2008.10.003 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2kie OCRL a ph domain within ocrl bridges clathrin mediated membrane trafficking to phosphoinositide metabolis -1.0Å AUTH Y.MAO,D.M.BALKIN,R.ZONCU,K.S.ERDMANN,L.TOMASINI,AUTH 2 F.HU,M.M.JIN,M.E.HODSDON,P.DE CAMILLITITL A PH DOMAIN WITHIN OCRL BRIDGES CLATHRIN-MEDIATEDTITL 2 MEMBRANE TRAFFICKING TO PHOSPHOINOSITIDE METABOLISMREF EMBO J. V. 28 1831 2009REFN ISSN 0261-4189PMID 19536138DOI 10.1038/EMBOJ.2009.155 Variant Set Distributions Mapped Variants
General Structure Information 2kmv ATP7A solution structure of the nucleotide binding domain of the human menkes protein in the atp-free form -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,S.INAGAKI,M.MIGLIARDI,AUTH 2 A.ROSATOTITL THE BINDING MODE OF ATP REVEALED BY THE SOLUTIONTITL 2 STRUCTURE OF THE N-DOMAIN OF HUMAN ATP7A.REF J.BIOL.CHEM. 2009REFN ESSN 1083-351XPMID 19917612DOI 10.1074/JBC.M109.054262 Variant Set Distributions Mapped Variants
General Structure Information 3i2b PTS the crystal structure of human 6 pyruvoyl tetrahydrobiopterin synthase 2.3Å AUTH E.UGOCHUKWU,R.COCKING,E.PILKA,W.W.YUE,J.E.BRAY,A.CHAIKUAD,AUTH 2 T.KROJER,J.MUNIZ,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN 6 PYRUVOYLTITL 2 TETRAHYDROBIOPTERIN SYNTHASEREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3jui EIF2B5 crystal structure of the c-terminal domain of human translation initiation factor eif2b epsilon subunit 2.0Å AUTH J.WEI,H.XU,C.ZHANG,M.WANG,F.GAO,W.GONGTITL CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMANTITL 2 TRANSLATION INITIATION FACTOR EIF2B EPSILON SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2k27 PAX8 solution structure of human pax8 paired box domain -1.0Å AUTH L.CODUTTI,H.VAN INGEN,C.VASCOTTO,F.FOGOLARI,AUTH 2 A.CORAZZA,G.TELL,F.QUADRIFOGLIO,P.VIGLINO,AUTH 3 R.BOELENS,G.ESPOSITOTITL THE SOLUTION STRUCTURE OF DNA-FREE PAX-8 PAIRED BOXTITL 2 DOMAIN ACCOUNTS FOR REDOX REGULATION OFTITL 3 TRANSCRIPTIONAL ACTIVITY IN THE PAX PROTEIN FAMILY.REF J.BIOL.CHEM. V. 283 33321 2008REFN ISSN 0021-9258PMID 18829450DOI 10.1074/JBC.M805717200 Variant Set […]