Assessment of Structural Intolerance and Durability
General Structure Information 3fe2 DDX5 human dead-box rna helicase ddx5 (p68), conserved domain i in complex with adp 2.6Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASESREF PLOS ONE V. 5 E1279 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Mapped Variants
General Structure Information 3mdi NUDT21 crystal structure of the 25kda subunit of human cleavage factor im in complex with rna uguaaa 2.07Å AUTH Q.YANG,G.M.GILMARTIN,S.DOUBLIETITL STRUCTURAL BASIS OF UGUA RECOGNITION BY THE NUDIX PROTEINTITL 2 CFI(M)25 AND IMPLICATIONS FOR A REGULATORY ROLE IN MRNA 3TITL 3 PROCESSING.REF PROC.NATL.ACAD.SCI.USA V. 107 10062 2010REFN ISSN 0027-8424PMID 20479262DOI 10.1073/PNAS.1000848107 […]
General Structure Information 2c46 RNGTT crystal structure of the human rna guanylyltransferase and 5-phosphatase 1.6Å AUTH J.DEBRECZENI,C.JOHANSSON,E.LONGMAN,O.GILEADI,P.SAVITSKYSMEE,AUTH 2 C.SMEE,G.BUNKOCZI,E.UGOCHUKWU,F.VON DELFT,M.SUNDSTROM,AUTH 3 J.WEIGELT,C.ARROWSMITH,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN RNA GUANYLYLTRANSFERASE ANDTITL 2 5-PHOSPHATASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2k1p ZRANB2 solution structure of the second zinc finger domain of zranb2/znf265 -1.0Å AUTH F.E.LOUGHLIN,R.E.MANSFIELD,P.M.VAZ,W.LEUNG,AUTH 2 S.SETIYAPUTRA,R.P.GRANT,E.S.CHEN,R.GAMSJAEGER,AUTH 3 J.P.MACKAYTITL THE ZINC FINGERS OF THE SR-PROEIN ZRANB2 RECOGNIZETITL 2 5SPLICE SITE-LIKE SEQUENCES AND CONSTITUTE ATITL 3 DISTINCT CLASS OF RNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3epp RNMT crystal structure of mrna cap guanine-n7 methyltransferase (rnmt) in complex with sinefungin 2.41Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 3 H.WUTITL CRYSTAL STRUCTURE OF MRNA CAP GUANINE-N7 METHYLTRANSFERASETITL 2 (RNMT) IN COMPLEX WITH SINEFUNGIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hyi CASC3 structure of the human exon junction complex with a trapped dead-box helicase bound to rna 2.3Å AUTH C.B.F.ANDERSEN,L.BALLUT,J.S.JOHANSEN,H.CHAMIEH,AUTH 2 K.H.NIELSEN,C.L.OLIVEIRA,J.S.PEDERSEN,B.SERAPHIN,AUTH 3 H.LE HIR,G.R.ANDERSENTITL STRUCTURE OF THE EXON JUNCTION CORE COMPLEX WITH ATITL 2 TRAPPED DEAD-BOX ATPASE BOUND TO RNA.REF SCIENCE V. 313 1968 2006REFN ISSN 0036-8075PMID 16931718DOI 10.1126/SCIENCE.1131981 Variant Set […]