Assessment of Structural Intolerance and Durability
General Structure Information 4iqm PUS1 crystal structure of the catalytic domain of human pus1 1.8Å AUTH N.CZUDNOCHOWSKI,A.L.WANG,J.FINER-MOORE,R.M.STROUDTITL IN HUMAN PSEUDOURIDINE SYNTHASE 1 (HPUS1), A C-TERMINALTITL 2 HELICAL INSERT BLOCKS TRNA FROM BINDING IN THE SAMETITL 3 ORIENTATION AS IN THE PUS1 BACTERIAL HOMOLOGUE TRUA,TITL 4 CONSISTENT WITH THEIR DIFFERENT TARGET SELECTIVITIES.REF J.MOL.BIOL. V. 425 3875 […]
General Structure Information 3ut1 L3MBTL3 crystal structure of the 3-mbt repeat domain of l3mbtl3 2.05Å AUTH N.ZHONG,W.TEMPEL,A.K.WERNIMONT,S.GRASLUND,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,P.J.BROWNTITL CRYSTAL STRUCTURE OF THE 3-MBT REPEAT DOMAIN OF L3MBTL3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fp9 NSUN4 human mterf4-nsun4 protein complex 2.9Å AUTH H.SPAHR,B.HABERMANN,C.M.GUSTAFSSON,N.G.LARSSON,B.M.HALLBERGTITL STRUCTURE OF THE HUMAN MTERF4-NSUN4 PROTEIN COMPLEX THATTITL 2 REGULATES MITOCHONDRIAL RIBOSOME BIOGENESIS.REF PROC.NATL.ACAD.SCI.USA V. 109 15253 2012REFN ISSN 0027-8424PMID 22949673DOI 10.1073/PNAS.1210688109 Variant Set Distributions Mapped Variants
General Structure Information 2aft SUMF1 formylglycine generating enzyme c336s mutant 1.66Å AUTH D.ROESER,A.PREUSSER-KUNZE,B.SCHMIDT,K.GASOW,J.G.WITTMANN,AUTH 2 T.DIERKS,K.VON FIGURA,M.G.RUDOLPHTITL A GENERAL BINDING MECHANISM FOR ALL HUMAN SULFATASES BY THETITL 2 FORMYLGLYCINE-GENERATING ENZYMEREF PROC.NATL.ACAD.SCI.USA V. 103 81 2006REFN ISSN 0027-8424PMID 16368756DOI 10.1073/PNAS.0507592102 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fmw TRMT10A crystal structure of methyltransferase domain of human rna (guanine-9- ) methyltransferase domain containing protein 2 2.0Å AUTH H.ZENG,A.DONG,P.LOPPNAU,W.TEMPEL,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,H.WUTITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN RNATITL 2 (GUANINE-9-) METHYLTRANSFERASE DOMAIN CONTAINING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3smt SETD3 crystal structure of human set domain-containing protein3 2.04Å AUTH H.ZENG,A.DONG,J.R.WALKER,P.LOPPNAU,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF HUMAN SET DOMAIN-CONTAINING PROTEIN3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2y1x CARM1 crystal structure of coactivator associated arginine methyltransferase 1 (carm1) in complex with sinefungin and indole inhibitor 2.4Å AUTH J.S.SACK,S.THIEFFINE,T.BANDIERA,M.FASOLINI,G.J.DUKE,AUTH 2 L.JAYARAMAN,K.F.KISH,H.E.KLEI,A.V.PURANDARE,P.ROSETTANI,AUTH 3 S.TROIANI,D.XIE,J.A.BERTRANDTITL STRUCTURAL BASIS FOR CARM1 INHIBITION BY INDOLE ANDTITL 2 PYRAZOLE INHIBITORSREF BIOCHEM.J. V. 436 331 2011REFN ISSN 0264-6021PMID 21410432DOI 10.1042/BJ20102161 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4fp9 MTERFD2 human mterf4-nsun4 protein complex 2.9Å AUTH H.SPAHR,B.HABERMANN,C.M.GUSTAFSSON,N.G.LARSSON,B.M.HALLBERGTITL STRUCTURE OF THE HUMAN MTERF4-NSUN4 PROTEIN COMPLEX THATTITL 2 REGULATES MITOCHONDRIAL RIBOSOME BIOGENESIS.REF PROC.NATL.ACAD.SCI.USA V. 109 15253 2012REFN ISSN 0027-8424PMID 22949673DOI 10.1073/PNAS.1210688109 Variant Set Distributions Mapped Variants
General Structure Information 4mi0 EZH2 human enhancer of zeste (drosophila) homolog 2(ezh2) 2.0Å AUTH H.WU,H.ZENG,A.DONG,F.LI,H.HE,G.SENISTERRA,A.SEITOVA,S.DUAN,AUTH 2 P.J.BROWN,M.VEDADI,C.H.ARROWSMITH,M.SCHAPIRATITL STRUCTURE OF THE CATALYTIC DOMAIN OF EZH2 REVEALSTITL 2 CONFORMATIONAL PLASTICITY IN COFACTOR AND SUBSTRATE BINDINGTITL 3 SITES AND EXPLAINS ONCOGENIC MUTATIONS.REF PLOS ONE V. 8 83737 2013REFN ESSN 1932-6203PMID 24367611DOI 10.1371/JOURNAL.PONE.0083737 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2v9k PUS10 crystal structure of human pus10, a novel pseudouridine synthase. 2.0Å AUTH C.J.MCCLEVERTY,M.HORNSBY,G.SPRAGGON,A.KREUSCHTITL CRYSTAL STRUCTURE OF HUMAN PUS10, A NOVEL PSEUDOURIDINETITL 2 SYNTHASE.REF J.MOL.BIOL. V. 373 1243 2007REFN ISSN 0022-2836PMID 17900615DOI 10.1016/J.JMB.2007.08.053 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants