Assessment of Structural Intolerance and Durability
General Structure Information 2lxs CREBBP allosteric communication in the kix domain proceeds through dynamic re-packing of the hydrophobic core -1.0Å AUTH S.BRUSCHWEILER,R.KONRAT,M.TOLLINGERTITL ALLOSTERIC COMMUNICATION IN THE KIX DOMAIN PROCEEDS THROUGHTITL 2 DYNAMIC REPACKING OF THE HYDROPHOBIC CORE.REF ACS CHEM.BIOL. 2013REFN ESSN 1554-8937PMID 23651431DOI 10.1021/CB4002188 Variant Set Distributions Mapped Variants
General Structure Information 2ysm KMT2C solution structure of the first and second phd domain from myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST AND SECOND PHDTITL 2 DOMAIN FROM MYELOID/LYMPHOID OR MIXED-LINEAGETITL 3 LEUKEMIA PROTEIN 3 HOMOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3dtc MAP3K9 crystal structure of mixed-lineage kinase mlk1 complexed with compound 16 2.6Å AUTH R.L.HUDKINS,J.L.DIEBOLD,M.TAO,K.A.JOSEF,C.H.PARK,AUTH 2 T.S.ANGELES,L.D.AIMONE,J.HUSTEN,M.A.ATOR,S.L.MEYER,AUTH 3 B.P.HOLSKIN,J.T.DURKIN,A.A.FEDOROV,E.V.FEDOROV,AUTH 4 S.C.ALMO,J.R.MATHIASEN,D.BOZYCZKO-COYNE,AUTH 5 M.S.SAPORITO,R.W.SCOTT,J.P.MALLAMOTITL MIXED-LINEAGE KINASE 1 AND MIXED-LINEAGE KINASE 3TITL 2 SUBTYPE-SELECTIVETITL 3 DIHYDRONAPHTHYL[3,4-A]PYRROLO[3,4-C]CARBAZOLE-5-TITL 4 ONES: OPTIMIZATION, MIXED-LINEAGE KINASE 1TITL 5 CRYSTALLOGRAPHY, AND ORAL IN VIVO ACTIVITY INTITL 6 1-METHYL-4-PHENYLTETRAHYDROPYRIDINE MODELS.REF J.MED.CHEM. […]
General Structure Information 3dtc MAP3K9 crystal structure of mixed-lineage kinase mlk1 complexed with compound 16 2.6Å AUTH R.L.HUDKINS,J.L.DIEBOLD,M.TAO,K.A.JOSEF,C.H.PARK,AUTH 2 T.S.ANGELES,L.D.AIMONE,J.HUSTEN,M.A.ATOR,S.L.MEYER,AUTH 3 B.P.HOLSKIN,J.T.DURKIN,A.A.FEDOROV,E.V.FEDOROV,AUTH 4 S.C.ALMO,J.R.MATHIASEN,D.BOZYCZKO-COYNE,AUTH 5 M.S.SAPORITO,R.W.SCOTT,J.P.MALLAMOTITL MIXED-LINEAGE KINASE 1 AND MIXED-LINEAGE KINASE 3TITL 2 SUBTYPE-SELECTIVETITL 3 DIHYDRONAPHTHYL[3,4-A]PYRROLO[3,4-C]CARBAZOLE-5-TITL 4 ONES: OPTIMIZATION, MIXED-LINEAGE KINASE 1TITL 5 CRYSTALLOGRAPHY, AND ORAL IN VIVO ACTIVITY INTITL 6 1-METHYL-4-PHENYLTETRAHYDROPYRIDINE MODELS.REF J.MED.CHEM. […]