Assessment of Structural Intolerance and Durability
General Structure Information 3bn3 ICAM5 crystal structure of icam-5 in complex with al i domain 2.1Å AUTH H.ZHANG,J.M.CASASNOVAS,M.JIN,J.H.LIU,C.G.GAHMBERG,AUTH 2 T.A.SPRINGER,J.-H.WANGTITL AN UNUSUAL ALLOSTERIC MOBILITY OF THE C-TERMINAL HELIX OF ATITL 2 HIGH-AFFINITY ALPHA L INTEGRIN I DOMAIN VARIANT BOUND TOTITL 3 ICAM-5REF MOL.CELL V. 31 432 2008REFN ISSN 1097-2765PMID 18691975DOI 10.1016/J.MOLCEL.2008.06.022 Variant Set Distributions Mapped […]
General Structure Information 4f7h FERMT2 the crystal structure of kindlin-2 pleckstrin homology domain in free form 1.9Å AUTH Y.LIU,Y.ZHU,S.YE,R.ZHANGTITL CRYSTAL STRUCTURE OF KINDLIN-2 PH DOMAIN REVEALS ATITL 2 CONFORMATIONAL TRANSITION FOR ITS MEMBRANE ANCHORING ANDTITL 3 REGULATION OF INTEGRIN ACTIVATION.REF PROTEIN CELL V. 3 434 2012REFN ISSN 1674-800XPMID 22653426DOI 10.1007/S13238-012-2046-1 Variant Set Distributions Mapped Variants
General Structure Information 2lgx FERMT2 nmr structure for kindle-2 n-terminus -1.0Å AUTH H.D.PERERA,Y.Q.MA,J.YANG,J.HIRBAWI,E.F.PLOW,J.QINTITL MEMBRANE BINDING OF THE N-TERMINAL UBIQUITIN-LIKE DOMAIN OFTITL 2 KINDLIN-2 IS CRUCIAL FOR ITS REGULATION OF INTEGRINTITL 3 ACTIVATION.REF STRUCTURE V. 19 1664 2011REFN ISSN 0969-2126PMID 22078565DOI 10.1016/J.STR.2011.08.012 Variant Set Distributions Mapped Variants
General Structure Information 3f7p PLEC crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 4hcr MADCAM1 crystal structure of human madcam-1 d1d2 complexed with fab pf-547659 2.3Å AUTH T.SPRINGER,Y.YU,J.ZHU,J.-H.WANG,P.-S.HUANGTITL A DIFFERENT FOLD WITH AN INTEGRIN-BINDING LOOP SPECIALIZEDTITL 2 FOR FLEXIBILITY IN MUCOSAL ADDRESSIN CELL ADHESIONTITL 3 MOLECULE-1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ny0 PTK2 crystal structure of ferm domain of human focal adhesion kinase 2.8Å AUTH K.BRAMI-CHERRIER,N.GERVASI,D.ARSENIEVA,K.WALKIEWICZ,AUTH 2 M.C.BOUTTERIN,A.ORTEGA,P.G.LEONARD,B.SEANTIER,L.GASMI,AUTH 3 T.BOUCEBA,G.KADARE,J.A.GIRAULT,S.T.AROLDTITL FAK DIMERIZATION CONTROLS ITS KINASE-DEPENDENT FUNCTIONS ATTITL 2 FOCAL ADHESIONS.REF EMBO J. V. 33 356 2014REFN ISSN 0261-4189PMID 24480479DOI 10.1002/EMBJ.201386399 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3sh5 HSPG2 calcium-bound laminin g like domain 3 from human perlecan 2.8Å AUTH B.VAN LE,H.KIM,J.CHOI,J.H.KIM,M.J.HAHN,C.LEE,K.K.KIM,AUTH 2 H.Y.HWANGTITL CRYSTAL STRUCTURE OF THE LG3 DOMAIN OF ENDOREPELLIN, ANTITL 2 ANGIOGENESIS INHIBITOR.REF J.MOL.BIOL. V. 414 231 2011REFN ISSN 0022-2836PMID 21996443DOI 10.1016/J.JMB.2011.09.048 Variant Set Distributions Mapped Variants
General Structure Information 1pt6 ITGA1 i domain from human integrin alpha1-beta1 1.87Å AUTH Y.NYMALM,J.S.PURANEN,T.K.M.NYHOLM,J.KAPYLA,H.KIDRON,AUTH 2 T.T.AIRENNE,J.HEINO,J.P.SLOTTE,M.S.JOHNSON,T.A.SALMINENTITL JARARHAGIN-DERIVED RKKH PEPTIDES INDUCE STRUCTURAL CHANGESTITL 2 IN ALPHA1I DOMAIN OF HUMAN INTEGRIN ALPHA1BETA1.REF J.BIOL.CHEM. V. 279 7962 2004REFN ISSN 0021-9258PMID 14660600DOI 10.1074/JBC.M312912200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3sh5 HSPG2 calcium-bound laminin g like domain 3 from human perlecan 2.8Å AUTH B.VAN LE,H.KIM,J.CHOI,J.H.KIM,M.J.HAHN,C.LEE,K.K.KIM,AUTH 2 H.Y.HWANGTITL CRYSTAL STRUCTURE OF THE LG3 DOMAIN OF ENDOREPELLIN, ANTITL 2 ANGIOGENESIS INHIBITOR.REF J.MOL.BIOL. V. 414 231 2011REFN ISSN 0022-2836PMID 21996443DOI 10.1016/J.JMB.2011.09.048 Variant Set Distributions Mapped Variants
General Structure Information 1pt6 ITGA1 i domain from human integrin alpha1-beta1 1.87Å AUTH Y.NYMALM,J.S.PURANEN,T.K.M.NYHOLM,J.KAPYLA,H.KIDRON,AUTH 2 T.T.AIRENNE,J.HEINO,J.P.SLOTTE,M.S.JOHNSON,T.A.SALMINENTITL JARARHAGIN-DERIVED RKKH PEPTIDES INDUCE STRUCTURAL CHANGESTITL 2 IN ALPHA1I DOMAIN OF HUMAN INTEGRIN ALPHA1BETA1.REF J.BIOL.CHEM. V. 279 7962 2004REFN ISSN 0021-9258PMID 14660600DOI 10.1074/JBC.M312912200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants