Assessment of Structural Intolerance and Durability
General Structure Information 2rb4 DDX25 crystal structure of the helicase domain of human ddx25 rna helicase 2.8Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Mapped Variants
General Structure Information 3ecs EIF2B1 crystal structure of human eif2b alpha 2.65Å AUTH T.B.HIYAMA,T.ITO,H.IMATAKA,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF HUMAN TRANSLATIONTITL 2 INITIATION FACTOR 2BREF J.MOL.BIOL. V. 392 937 2009REFN ISSN 0022-2836PMID 19631657DOI 10.1016/J.JMB.2009.07.054 Variant Set Distributions Mapped Variants
General Structure Information 3bor EIF4A2 crystal structure of the deadc domain of human translation initiation factor 4a-2 1.85Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1jfi DR1 crystal structure of the nc2-tbp-dna ternary complex 2.62Å AUTH K.KAMADA,F.SHU,H.CHEN,S.MALIK,G.STELZER,R.G.ROEDER,AUTH 2 M.MEISTERERNST,S.K.BURLEYTITL CRYSTAL STRUCTURE OF NEGATIVE COFACTOR 2TITL 2 RECOGNIZING THE TBP-DNA TRANSCRIPTION COMPLEX.REF CELL(CAMBRIDGE,MASS.) V. 106 71 2001REFN ISSN 0092-8674PMID 11461703DOI 10.1016/S0092-8674(01)00417-2 Variant Set Distributions Mapped Variants
General Structure Information 1jfi DR1 crystal structure of the nc2-tbp-dna ternary complex 2.62Å AUTH K.KAMADA,F.SHU,H.CHEN,S.MALIK,G.STELZER,R.G.ROEDER,AUTH 2 M.MEISTERERNST,S.K.BURLEYTITL CRYSTAL STRUCTURE OF NEGATIVE COFACTOR 2TITL 2 RECOGNIZING THE TBP-DNA TRANSCRIPTION COMPLEX.REF CELL(CAMBRIDGE,MASS.) V. 106 71 2001REFN ISSN 0092-8674PMID 11461703DOI 10.1016/S0092-8674(01)00417-2 Variant Set Distributions Mapped Variants
General Structure Information 1jfi DR1 crystal structure of the nc2-tbp-dna ternary complex 2.62Å AUTH K.KAMADA,F.SHU,H.CHEN,S.MALIK,G.STELZER,R.G.ROEDER,AUTH 2 M.MEISTERERNST,S.K.BURLEYTITL CRYSTAL STRUCTURE OF NEGATIVE COFACTOR 2TITL 2 RECOGNIZING THE TBP-DNA TRANSCRIPTION COMPLEX.REF CELL(CAMBRIDGE,MASS.) V. 106 71 2001REFN ISSN 0092-8674PMID 11461703DOI 10.1016/S0092-8674(01)00417-2 Variant Set Distributions Mapped Variants
General Structure Information 1jfi DR1 crystal structure of the nc2-tbp-dna ternary complex 2.62Å AUTH K.KAMADA,F.SHU,H.CHEN,S.MALIK,G.STELZER,R.G.ROEDER,AUTH 2 M.MEISTERERNST,S.K.BURLEYTITL CRYSTAL STRUCTURE OF NEGATIVE COFACTOR 2TITL 2 RECOGNIZING THE TBP-DNA TRANSCRIPTION COMPLEX.REF CELL(CAMBRIDGE,MASS.) V. 106 71 2001REFN ISSN 0092-8674PMID 11461703DOI 10.1016/S0092-8674(01)00417-2 Variant Set Distributions Mapped Variants
General Structure Information 1jfi DR1 crystal structure of the nc2-tbp-dna ternary complex 2.62Å AUTH K.KAMADA,F.SHU,H.CHEN,S.MALIK,G.STELZER,R.G.ROEDER,AUTH 2 M.MEISTERERNST,S.K.BURLEYTITL CRYSTAL STRUCTURE OF NEGATIVE COFACTOR 2TITL 2 RECOGNIZING THE TBP-DNA TRANSCRIPTION COMPLEX.REF CELL(CAMBRIDGE,MASS.) V. 106 71 2001REFN ISSN 0092-8674PMID 11461703DOI 10.1016/S0092-8674(01)00417-2 Variant Set Distributions Mapped Variants
General Structure Information 2qpw PRDM2 methyltransferase domain of human pr domain-containing protein 2 1.79Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Mapped Variants
General Structure Information 3jui EIF2B5 crystal structure of the c-terminal domain of human translation initiation factor eif2b epsilon subunit 2.0Å AUTH J.WEI,H.XU,C.ZHANG,M.WANG,F.GAO,W.GONGTITL CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMANTITL 2 TRANSLATION INITIATION FACTOR EIF2B EPSILON SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants