Assessment of Structural Intolerance and Durability
General Structure Information 1yb1 HSD17B11 crystal structure of human 17-beta-hydroxysteroid dehydrogenase type xi 1.95Å AUTH P.LUKACIK,G.BUNKOCZI,K.KAVANAGH,S.NG,F.VON DELFT,J.BRAY,AUTH 2 A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROIDTITL 2 DEHYDROGENASE TYPE XI.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3kvo HSDL2 crystal structure of the catalytic domain of human hydroxysteroid dehydrogenase like 2 (hsdl2) 2.25Å AUTH E.UGOCHUKWU,C.BHATIA,J.HUANG,E.PILKA,J.R.C.MUNIZ,A.C.W.PIKE,AUTH 2 T.KROJER,F.VON DELFT,E.M.VERDIN,U.OPPERMANN,K.L.KAVANAGHTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 HYDROXYSTEROID DEHYDROGENASE LIKE 2 (HSDL2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1zbq HSD17B4 crystal structure of human 17-beta-hydroxysteroid dehydrogenase type 4 in complex with nad 2.71Å AUTH P.LUKACIK,N.SHAFQAT,K.KAVANAGH,J.BRAY,F.VON DELFT,A.EDWARDS,AUTH 2 C.ARROWSMITH,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROIDTITL 2 DEHYDROGENASE TYPE 4 IN COMPLEX WITH NADREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants