Assessment of Structural Intolerance and Durability
General Structure Information 3h5c SERPINA10 x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3mqm ASH1L crystal structure of the bromodomain of human ash1l 2.54Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 2r2q GABARAPL1 crystal structure of human gamma-aminobutyric acid receptor- associated protein-like 1 (gabarap1), isoform cra_a 1.65Å AUTH R.PARAMANATHAN,T.DAVIS,W.TEMPEL,S.MUJIB,AUTH 2 C.BUTLER-COLE,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF HUMAN GAMMA-AMINOBUTYRIC ACIDTITL 2 RECEPTOR-ASSOCIATED PROTEIN-LIKE 1 (GABARAP1),TITL 3 ISOFORM CRA_A.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1um7 DLG3 solution structure of the third pdz domain of synapse- associated protein 102 -1.0Å AUTH X.-R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD PDZ DOMAIN OFTITL 2 SYNAPSE-ASSOCIATED PROTEIN 102REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2uzc PDLIM5 structure of human pdlim5 in complex with the c-terminal peptide of human alpha-actinin-1 1.5Å AUTH J.M.ELKINS,C.GILEADI,L.SHRESTHA,C.PHILLIPS,J.WANG,AUTH 2 J.R.C.MUNIZ,D.A.DOYLETITL UNUSUAL BINDING INTERACTIONS IN PDZ DOMAIN CRYSTALTITL 2 STRUCTURES HELP EXPLAIN BINDING MECHANISMS.REF PROTEIN SCI. V. 19 731 2010REFN ISSN 0961-8368PMID 20120020DOI 10.1002/PRO.349 Variant Set Distributions Mapped Variants
General Structure Information 2yrh ZNF473 solution structure of the c2h2-type zinc finger domain (699- 729) from zinc finger protein 473 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2-TYPE ZINC FINGERTITL 2 DOMAIN (699-729) FROM ZINC FINGER PROTEIN 473REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3rq4 SUV420H2 crystal structure of suppressor of variegation 4-20 homolog 2 1.8Å AUTH H.WU,A.SIARHEYEVA,H.ZENG,R.LAM,A.DONG,X.H.WU,Y.LI,AUTH 2 M.SCHAPIRA,M.VEDADI,J.MINTITL CRYSTAL STRUCTURES OF THE HUMAN HISTONE H4K20TITL 2 METHYLTRANSFERASES SUV420H1 AND SUV420H2.REF FEBS LETT. V. 587 3859 2013REFN ISSN 0014-5793PMID 24396869 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4b87 DCLRE1A crystal structure of human dna cross-link repair 1a 2.16Å AUTH C.K.ALLERSTON,G.BERRIDGE,E.P.CARPENTER,G.KOCHAN,T.KROJER,AUTH 2 P.MAHAJAN,M.VOLLMAR,W.W.YUE,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF HUMAN DNA CROSS-LINK REPAIR 1AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2e7k MPP2 solution structure of the pdz domain from human maguk p55 subfamily member 2 -1.0Å AUTH X.R.QIN,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN FROM HUMANTITL 2 MAGUK P55 SUBFAMILY MEMBER 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2e7k MPP2 solution structure of the pdz domain from human maguk p55 subfamily member 2 -1.0Å AUTH X.R.QIN,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN FROM HUMANTITL 2 MAGUK P55 SUBFAMILY MEMBER 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants