Assessment of Structural Intolerance and Durability
General Structure Information 3eij PDCD4 crystal structure of pdcd4 2.8Å AUTH P.G.LOH,H.-S.YANG,M.A.WALSH,Q.WANG,X.WANG,Z.CHENG,D.LIU,AUTH 2 H.SONGTITL STRUCTURAL BASIS FOR TRANSLATIONAL INHIBITION BY THE TUMOURTITL 2 SUPPRESSOR PDCD4REF EMBO J. V. 28 274 2009REFN ISSN 0261-4189PMID 19153607DOI 10.1038/EMBOJ.2008.278 Variant Set Distributions Mapped Variants
General Structure Information 2p8q KPNB1 crystal structure of human importin beta bound to the snurportin1 ibb- domain 2.35Å AUTH G.MITROUSIS,A.S.OLIA,N.WALKER-KOPP,G.CINGOLANITITL MOLECULAR BASIS FOR THE RECOGNITION OF SNURPORTIN 1 BYTITL 2 IMPORTIN {BETA}.REF J.BIOL.CHEM. V. 283 7877 2008REFN ISSN 0021-9258PMID 18187419DOI 10.1074/JBC.M709093200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2p8q KPNB1 crystal structure of human importin beta bound to the snurportin1 ibb- domain 2.35Å AUTH G.MITROUSIS,A.S.OLIA,N.WALKER-KOPP,G.CINGOLANITITL MOLECULAR BASIS FOR THE RECOGNITION OF SNURPORTIN 1 BYTITL 2 IMPORTIN {BETA}.REF J.BIOL.CHEM. V. 283 7877 2008REFN ISSN 0021-9258PMID 18187419DOI 10.1074/JBC.M709093200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2p8q KPNB1 crystal structure of human importin beta bound to the snurportin1 ibb- domain 2.35Å AUTH G.MITROUSIS,A.S.OLIA,N.WALKER-KOPP,G.CINGOLANITITL MOLECULAR BASIS FOR THE RECOGNITION OF SNURPORTIN 1 BYTITL 2 IMPORTIN {BETA}.REF J.BIOL.CHEM. V. 283 7877 2008REFN ISSN 0021-9258PMID 18187419DOI 10.1074/JBC.M709093200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1ug3 EIF4G1 c-terminal portion of human eif4gi 2.24Å AUTH L.BELLSOLELL,P.F.CHO-PARK,F.POULIN,N.SONENBERG,AUTH 2 S.K.BURLEYTITL TWO STRUCTURALLY ATYPICAL HEAT DOMAINS IN THETITL 2 C-TERMINAL PORTION OF HUMAN EIF4G SUPPORT BINDINGTITL 3 TO EIF4A AND MNK1REF STRUCTURE V. 14 913 2006REFN ISSN 0969-2126PMID 16698542DOI 10.1016/J.STR.2006.03.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1ukl SREBF2 crystal structure of importin-beta and srebp-2 complex 3.0Å AUTH S.J.LEE,T.SEKIMOTO,E.YAMASHITA,E.NAGOSHI,AUTH 2 A.NAKAGAWA,N.IMAMOTO,M.YOSHIMURA,H.SAKAI,K.T.CHONG,AUTH 3 T.TSUKIHARA,Y.YONEDATITL THE STRUCTURE OF IMPORTIN-BETA BOUND TO SREBP-2:TITL 2 NUCLEAR IMPORT OF A TRANSCRIPTION FACTORREF SCIENCE V. 302 1571 2003REFN ISSN 0036-8075PMID 14645851DOI 10.1126/SCIENCE.1088372 Variant Set Distributions Mapped Variants
General Structure Information 2nyl PPP2R5C crystal structure of protein phosphatase 2a (pp2a) holoenzyme with the catalytic subunit carboxyl terminus truncated 3.8Å AUTH Y.XU,Y.XING,Y.CHEN,Y.CHAO,Z.LIN,E.FAN,J.W.YU,S.STRACK,AUTH 2 P.D.JEFFREY,Y.SHITITL STRUCTURE OF THE PROTEIN PHOSPHATASE 2A HOLOENZYME.REF CELL(CAMBRIDGE,MASS.) V. 127 1239 2006REFN ISSN 0092-8674PMID 17174897DOI 10.1016/J.CELL.2006.11.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3jui EIF2B5 crystal structure of the c-terminal domain of human translation initiation factor eif2b epsilon subunit 2.0Å AUTH J.WEI,H.XU,C.ZHANG,M.WANG,F.GAO,W.GONGTITL CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMANTITL 2 TRANSLATION INITIATION FACTOR EIF2B EPSILON SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hb4 RAN crystal structure of crm1 inhibitor leptomycin b in complex with crm1(537dltvk541/glceq)-ran-ranbp1 2.05Å AUTH Q.SUN,Y.P.CARRASCO,Y.HU,X.GUO,H.MIRZAEI,J.MACMILLAN,AUTH 2 Y.M.CHOOKTITL NUCLEAR EXPORT INHIBITION THROUGH COVALENT CONJUGATION ANDTITL 2 HYDROLYSIS OF LEPTOMYCIN B BY CRM1.REF PROC.NATL.ACAD.SCI.USA V. 110 1303 2013REFN ISSN 0027-8424PMID 23297231DOI 10.1073/PNAS.1217203110 Variant Set Distributions Mapped Variants
General Structure Information 1ukl SREBF2 crystal structure of importin-beta and srebp-2 complex 3.0Å AUTH S.J.LEE,T.SEKIMOTO,E.YAMASHITA,E.NAGOSHI,AUTH 2 A.NAKAGAWA,N.IMAMOTO,M.YOSHIMURA,H.SAKAI,K.T.CHONG,AUTH 3 T.TSUKIHARA,Y.YONEDATITL THE STRUCTURE OF IMPORTIN-BETA BOUND TO SREBP-2:TITL 2 NUCLEAR IMPORT OF A TRANSCRIPTION FACTORREF SCIENCE V. 302 1571 2003REFN ISSN 0036-8075PMID 14645851DOI 10.1126/SCIENCE.1088372 Variant Set Distributions Mapped Variants