General Structure Information 3ewf HDAC8 crystal structure analysis of human hdac8 h143a variant complexed with substrate. 2.5Å AUTH D.P.DOWLING,S.L.GANTT,S.G.GATTIS,C.A.FIERKE,AUTH 2 D.W.CHRISTIANSONTITL STRUCTURAL STUDIES OF HUMAN HISTONE DEACETYLASE 8TITL 2 AND ITS SITE-SPECIFIC VARIANTS COMPLEXED WITHTITL 3 SUBSTRATE AND INHIBITORS.REF BIOCHEMISTRY V. 47 13554 2008REFN ISSN 0006-2960PMID 19053282DOI 10.1021/BI801610C Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 4bkx HDAC1 the structure of hdac1 in complex with the dimeric elm2-sant domain of mta1 from the nurd complex 3.0Å AUTH C.J.MILLARD,P.J.WATSON,I.CELARDO,Y.GORDIYENKO,S.M.COWLEY,AUTH 2 C.V.ROBINSON,L.FAIRALL,J.W.R.SCHWABETITL CLASS I HDACS SHARE A COMMON MECHANISM OF REGULATION BYTITL 2 INOSITOL PHOSPHATES.REF MOL.CELL V. 51 57 2013REFN ISSN 1097-2765PMID 23791785DOI 10.1016/J.MOLCEL.2013.05.020 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4a8x RNPS1 structure of the core asap complex 1.9Å AUTH A.G.MURACHELLI,J.EBERT,C.BASQUIN,H.LE HIR,E.CONTITITL THE STRUCTURE OF THE ASAP CORE COMPLEX REVEALS THETITL 2 EXISTENCE OF A PININ-CONTAINING PSAP COMPLEXREF NAT.STRUCT.MOL.BIOL. V. 19 378 2012REFN ISSN 1545-9993PMID 22388736DOI 10.1038/NSMB.2242 Variant Set Distributions Mapped Variants
General Structure Information 4bkx MTA1 the structure of hdac1 in complex with the dimeric elm2-sant domain of mta1 from the nurd complex 3.0Å AUTH C.J.MILLARD,P.J.WATSON,I.CELARDO,Y.GORDIYENKO,S.M.COWLEY,AUTH 2 C.V.ROBINSON,L.FAIRALL,J.W.R.SCHWABETITL CLASS I HDACS SHARE A COMMON MECHANISM OF REGULATION BYTITL 2 INOSITOL PHOSPHATES.REF MOL.CELL V. 51 57 2013REFN ISSN 1097-2765PMID 23791785DOI 10.1016/J.MOLCEL.2013.05.020 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2vqv HDAC4 structure of hdac4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor 3.3Å AUTH M.J.BOTTOMLEY,P.LO SURDO,P.DI GIOVINE,A.CIRILLO,AUTH 2 R.SCARPELLI,F.FERRIGNO,P.JONES,P.NEDDERMANN,AUTH 3 R.DE FRANCESCO,C.STEINKUHLER,P.GALLINARI,A.CARFITITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE HUMANTITL 2 HDAC4 CATALYTIC DOMAIN REVEALS A REGULATORYTITL 3 STRUCTURAL ZINC-BINDING DOMAIN.REF J.BIOL.CHEM. V. 283 26694 2008REFN ISSN 0021-9258PMID […]
General Structure Information 4bkx MTA1 the structure of hdac1 in complex with the dimeric elm2-sant domain of mta1 from the nurd complex 3.0Å AUTH C.J.MILLARD,P.J.WATSON,I.CELARDO,Y.GORDIYENKO,S.M.COWLEY,AUTH 2 C.V.ROBINSON,L.FAIRALL,J.W.R.SCHWABETITL CLASS I HDACS SHARE A COMMON MECHANISM OF REGULATION BYTITL 2 INOSITOL PHOSPHATES.REF MOL.CELL V. 51 57 2013REFN ISSN 1097-2765PMID 23791785DOI 10.1016/J.MOLCEL.2013.05.020 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2vqv HDAC4 structure of hdac4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor 3.3Å AUTH M.J.BOTTOMLEY,P.LO SURDO,P.DI GIOVINE,A.CIRILLO,AUTH 2 R.SCARPELLI,F.FERRIGNO,P.JONES,P.NEDDERMANN,AUTH 3 R.DE FRANCESCO,C.STEINKUHLER,P.GALLINARI,A.CARFITITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE HUMANTITL 2 HDAC4 CATALYTIC DOMAIN REVEALS A REGULATORYTITL 3 STRUCTURAL ZINC-BINDING DOMAIN.REF J.BIOL.CHEM. V. 283 26694 2008REFN ISSN 0021-9258PMID […]
General Structure Information 2hde SAP18 solution structure of human sap18 -1.0Å AUTH S.A.MCCALLUM,J.F.BAZAN,M.MERCHANT,J.YIN,B.PAN,AUTH 2 F.J.DE SAUVAGE,W.J.FAIRBROTHERTITL STRUCTURE OF SAP18: A UBIQUITIN FOLD IN HISTONETITL 2 DEACETYLASE COMPLEX ASSEMBLY.REF BIOCHEMISTRY V. 45 11974 2006REFN ISSN 0006-2960PMID 17002296DOI 10.1021/BI060687L Variant Set Distributions Mapped Variants