Assessment of Structural Intolerance and Durability
General Structure Information 3ltl ARFGEF1 crystal structure of human big1 sec7 domain 2.2Å AUTH J.C.ZEEH,P.C.SIMISTER,V.ROUSSEAU,A.JOUBERT,J.CHERFILS,V.BIOUTITL THE SEC7 DOMAIN STRUCTURES OF HUMAN BIG1 AND CYTOHESIN1 ARFTITL 2 NUCLEOTIDE EXCHANGE FACTORSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1txu RABGEF1 crystal structure of the vps9 domain of rabex-5 2.35Å AUTH A.DELPRATO,E.MERITHEW,D.G.LAMBRIGHTTITL STRUCTURE, EXCHANGE DETERMINANTS, AND FAMILY-WIDETITL 2 RAB SPECIFICITY OF THE TANDEM HELICAL BUNDLE ANDTITL 3 VPS9 DOMAINS OF RABEX-5REF CELL(CAMBRIDGE,MASS.) V. 118 607 2004REFN ISSN 0092-8674PMID 15339665DOI 10.1016/J.CELL.2004.08.009 Variant Set Distributions Mapped Variants
General Structure Information 1txu KCTD7 crystal structure of the vps9 domain of rabex-5 2.35Å AUTH A.DELPRATO,E.MERITHEW,D.G.LAMBRIGHTTITL STRUCTURE, EXCHANGE DETERMINANTS, AND FAMILY-WIDETITL 2 RAB SPECIFICITY OF THE TANDEM HELICAL BUNDLE ANDTITL 3 VPS9 DOMAINS OF RABEX-5REF CELL(CAMBRIDGE,MASS.) V. 118 607 2004REFN ISSN 0092-8674PMID 15339665DOI 10.1016/J.CELL.2004.08.009 Variant Set Distributions Mapped Variants
General Structure Information 3l46 ECT2 crystal structure of the second brct domain of epithelial cell transforming 2 (ect2) 1.48Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,L.CROMBET,H.WANG,X.GUAN,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE SECOND BRCT DOMAIN OF EPITHELIALTITL 2 CELL TRANSFORMING 2 (ECT2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2wmn DOCK9 structure of the complex between dock9 and cdc42-gdp. 2.39Å AUTH J.YANG,Z.ZHANG,S.M.ROE,C.J.MARSHALL,D.BARFORDTITL ACTIVATION OF RHO GTPASES BY DOCK EXCHANGE FACTORSTITL 2 IS MEDIATED BY A NUCLEOTIDE SENSOR.REF SCIENCE V. 325 1398 2009REFN ISSN 0036-8075PMID 19745154DOI 10.1126/SCIENCE.1174468 Variant Set Distributions Mapped Variants
General Structure Information 3a98 DOCK2 crystal structure of the complex of the interacting regions of dock2 and elmo1 2.1Å AUTH K.HANAWA-SUETSUGU,M.KUKIMOTO-NIINO,C.MISHIMA-TSUMAGARI,AUTH 2 R.AKASAKA,N.OHSAWA,S.SEKINE,T.ITO,N.TOCHIO,S.KOSHIBA,AUTH 3 T.KIGAWA,T.TERADA,M.SHIROUZU,D.KOHDA,A.NISHIKIMI,Y.FUKUI,AUTH 4 S.YOKOYAMATITL STRUCTURAL BASIS OF FUNCTIONAL COMPLEX FORMATION BETWEENTITL 2 DOCK2 AND ELMO1 FOR RAC ACTIVATION IN LYMPHOCYTE CHEMOTAXISREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3a98 ELMO1 crystal structure of the complex of the interacting regions of dock2 and elmo1 2.1Å AUTH K.HANAWA-SUETSUGU,M.KUKIMOTO-NIINO,C.MISHIMA-TSUMAGARI,AUTH 2 R.AKASAKA,N.OHSAWA,S.SEKINE,T.ITO,N.TOCHIO,S.KOSHIBA,AUTH 3 T.KIGAWA,T.TERADA,M.SHIROUZU,D.KOHDA,A.NISHIKIMI,Y.FUKUI,AUTH 4 S.YOKOYAMATITL STRUCTURAL BASIS OF FUNCTIONAL COMPLEX FORMATION BETWEENTITL 2 DOCK2 AND ELMO1 FOR RAC ACTIVATION IN LYMPHOCYTE CHEMOTAXISREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3eo2 NET1 crystal structure of the rhogef domain of human neuroepithelial cell- transforming gene 1 protein 2.6Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGEF DOMAIN OF HUMANTITL 2 NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qxl RALGPS1 crystal structure of the cdc25 domain from ral-specific guanine- nucleotide exchange factor ralgps1a 2.24Å AUTH W.PENG,J.XU,X.GUAN,Y.SUN,X.C.ZHANG,X.LI,Z.RAOTITL STRUCTURAL STUDY OF THE CDC25 DOMAIN FROM RAL-SPECIFICTITL 2 GUANINE-NUCLEOTIDE EXCHANGE FACTOR RALGPS1A.REF PROTEIN CELL V. 2 308 2011REFN ISSN 1674-800XPMID 21494904DOI 10.1007/S13238-011-1036-Z Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3l4c DOCK1 structural basis of membrane-targeting by dock180 2.37Å AUTH L.PREMKUMAR,A.A.BOBKOV,M.PATEL,L.JAROSZEWSKI,L.A.BANKSTON,AUTH 2 B.STEC,K.VUORI,J.F.COTE,R.C.LIDDINGTONTITL STRUCTURAL BASIS OF MEMBRANE TARGETING BY THE DOCK180TITL 2 FAMILY OF RHO FAMILY GUANINE EXCHANGE FACTORS (RHO-GEFS).REF J.BIOL.CHEM. V. 285 13211 2010REFN ISSN 0021-9258PMID 20167601DOI 10.1074/JBC.M110.102517 Variant Set Distributions Mapped Variants