Assessment of Structural Intolerance and Durability
General Structure Information 4mpm NGB wild-type human neuroglobin 1.74Å AUTH B.G.GUIMARAES,D.HAMDANE,C.LECHAUVE,M.C.MARDEN,AUTH 2 B.GOLINELLI-PIMPANEAUTITL THE CRYSTAL STRUCTURE OF WILD-TYPE HUMAN BRAIN NEUROGLOBINTITL 2 REVEALS FLEXIBILITY OF THE DISULFIDE BOND THAT REGULATESTITL 3 OXYGEN AFFINITY.REF ACTA CRYSTALLOGR.,SECT.D V. 70 1005 2014REFN ISSN 0907-4449PMID 24699645DOI 10.1107/S1399004714000078 Variant Set Distributions Mapped Variants
General Structure Information 1ury CYGB cytoglobin cavities 2.4Å AUTH D.DE SANCTIS,S.DEWILDE,A.PESCE,L.MOENS,P.ASCENZI,AUTH 2 T.HANKELN,T.BURMESTER,M.BOLOGNESITITL CYTOGLOBIN CAVITIESREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 316 1217 2004REFN ISSN 0006-291XPMID 15044115DOI 10.1016/J.BBRC.2004.03.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1xye HBB t-to-thigh transitions in human hemoglobin: alpha y42a deoxy low salt 2.13Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONE,H.L.HUI,AUTH 2 A.WIERZBA,A.DEYOUNG,L.D.KWIATKOWSKI,R.W.NOBLE,AUTH 3 L.J.JUSZCZAK,E.S.PETERSON,J.M.FRIEDMANTITL INTERSUBUNIT INTERACTIONS ASSOCIATED WITHTITL 2 TYR42ALPHA STABILIZE THE QUATERNARY-T TETRAMER BUTTITL 3 ARE NOT MAJOR QUATERNARY CONSTRAINTS INTITL 4 DEOXYHEMOGLOBINREF BIOCHEMISTRY V. 44 3806 2005REFN ISSN 0006-2960PMID 15751957DOI 10.1021/BI0484670 Variant Set Distributions Ripley’s […]
General Structure Information 1xye HBB t-to-thigh transitions in human hemoglobin: alpha y42a deoxy low salt 2.13Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONE,H.L.HUI,AUTH 2 A.WIERZBA,A.DEYOUNG,L.D.KWIATKOWSKI,R.W.NOBLE,AUTH 3 L.J.JUSZCZAK,E.S.PETERSON,J.M.FRIEDMANTITL INTERSUBUNIT INTERACTIONS ASSOCIATED WITHTITL 2 TYR42ALPHA STABILIZE THE QUATERNARY-T TETRAMER BUTTITL 3 ARE NOT MAJOR QUATERNARY CONSTRAINTS INTITL 4 DEOXYHEMOGLOBINREF BIOCHEMISTRY V. 44 3806 2005REFN ISSN 0006-2960PMID 15751957DOI 10.1021/BI0484670 Variant Set Distributions Ripley’s […]
General Structure Information 1yg5 HBA2 t-to-t(high) quaternary transitions in human hemoglobin: betaw37h oxy (2mm ihp, 20% peg) (10 test sets) 2.7Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONETITL CRYSTALLOGRAPHIC EVIDENCE FOR A NEW ENSEMBLE OFTITL 2 LIGAND-INDUCED ALLOSTERIC TRANSITIONS INTITL 3 HEMOGLOBIN: THE T-TO-T(HIGH) QUATERNARYTITL 4 TRANSITIONS.REF BIOCHEMISTRY V. 44 6101 2005REFN ISSN 0006-2960PMID 15835899DOI 10.1021/BI047813A Variant Set Distributions Pathogenic […]
General Structure Information 1yg5 HBA1 t-to-t(high) quaternary transitions in human hemoglobin: betaw37h oxy (2mm ihp, 20% peg) (10 test sets) 2.7Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONETITL CRYSTALLOGRAPHIC EVIDENCE FOR A NEW ENSEMBLE OFTITL 2 LIGAND-INDUCED ALLOSTERIC TRANSITIONS INTITL 3 HEMOGLOBIN: THE T-TO-T(HIGH) QUATERNARYTITL 4 TRANSITIONS.REF BIOCHEMISTRY V. 44 6101 2005REFN ISSN 0006-2960PMID 15835899DOI 10.1021/BI047813A Variant Set Distributions Pathogenic […]