General Structure Information 3kjd PARP2 human poly(adp-ribose) polymerase 2, catalytic fragment in complex with an inhibitor abt-888 1.95Å AUTH T.KARLBERG,M.HAMMARSTROM,P.SCHUTZ,L.SVENSSON,H.SCHULERTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PARP2 INTITL 2 COMPLEX WITH PARP INHIBITOR ABT-888.REF BIOCHEMISTRY V. 49 1056 2010REFN ISSN 0006-2960PMID 20092359DOI 10.1021/BI902079Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2pqf PARP12 human poly(adp-ribose) polymerase 12, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid 2.2Å AUTH T.KARLBERG,M.KLEPSCH,A.G.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASE ACTIVITYTITL 2 IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGER ANTIVIRALTITL 3 PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1f3m PAK1 crystal structure of human serine/threonine kinase pak1 2.3Å AUTH M.LEI,W.LU,W.MENG,M.C.PARRINI,M.J.ECK,B.J.MAYER,AUTH 2 S.C.HARRISONTITL STRUCTURE OF PAK1 IN AN AUTOINHIBITED CONFORMATIONTITL 2 REVEALS A MULTISTAGE ACTIVATION SWITCH.REF CELL(CAMBRIDGE,MASS.) V. 102 387 2000REFN ISSN 0092-8674PMID 10975528DOI 10.1016/S0092-8674(00)00043-X Variant Set Distributions Mapped Variants
General Structure Information 1f3m PAK1 crystal structure of human serine/threonine kinase pak1 2.3Å AUTH M.LEI,W.LU,W.MENG,M.C.PARRINI,M.J.ECK,B.J.MAYER,AUTH 2 S.C.HARRISONTITL STRUCTURE OF PAK1 IN AN AUTOINHIBITED CONFORMATIONTITL 2 REVEALS A MULTISTAGE ACTIVATION SWITCH.REF CELL(CAMBRIDGE,MASS.) V. 102 387 2000REFN ISSN 0092-8674PMID 10975528DOI 10.1016/S0092-8674(00)00043-X Variant Set Distributions Mapped Variants
General Structure Information 3v6o LEPR leptin receptor-antibody complex 1.95Å AUTH B.CARPENTER,G.R.HEMSWORTH,Z.WU,M.MAAMRA,C.J.STRASBURGER,AUTH 2 R.J.ROSS,P.J.ARTYMIUKTITL STRUCTURE OF THE HUMAN OBESITY RECEPTOR LEPTIN-BINDINGTITL 2 DOMAIN REVEALS THE MECHANISM OF LEPTIN ANTAGONISM BY ATITL 3 MONOCLONAL ANTIBODY.REF STRUCTURE V. 20 487 2012REFN ISSN 0969-2126PMID 22405007DOI 10.1016/J.STR.2012.01.019 Variant Set Distributions Mapped Variants
General Structure Information 4bkt VHL von hippel lindau protein:elonginb:elonginc complex, in complex with (2s,4r)-n-methyl-1-[2-(3-methyl-1,2-oxazol-5-yl)ethanoyl]-4- oxidanyl-pyrrolidine-2-carboxamide 2.35Å AUTH D.M.DIAS,I.VAN MOLLE,M.G.J.BAUD,C.GALDEANO,C.F.G.C.GERALDES,AUTH 2 A.CIULLITITL IS NMR FRAGMENT SCREENING FINE-TUNED TO ASSESS DRUGGABILITYTITL 2 OF PROTEIN-PROTEIN INTERACTIONS?REF ACS MED.CHEM.LETT. V. 5 23 2014REFN ISSN 1948-5875PMID 24436777DOI 10.1021/ML400296C Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1apj FBN1 nmr study of the transforming growth factor beta binding protein-like domain (tb module/8-cys domain), nmr, 21 structures -1.0Å AUTH X.YUAN,A.K.DOWNING,V.KNOTT,P.A.HANDFORDTITL SOLUTION STRUCTURE OF THE TRANSFORMING GROWTHTITL 2 FACTOR BETA-BINDING PROTEIN-LIKE MODULE, A DOMAINTITL 3 ASSOCIATED WITH MATRIX FIBRILS.REF EMBO J. V. 16 6659 1997REFN ISSN 0261-4189PMID 9362480DOI 10.1093/EMBOJ/16.22.6659 Variant Set […]
General Structure Information 1v7n THPO human thrombopoietin functional domain complexed to neutralizing antibody tn1 fab 3.3Å AUTH M.D.FEESE,T.TAMADA,Y.KATO,Y.MAEDA,M.HIROSE,AUTH 2 Y.MATSUKURA,H.SHIGEMATSU,T.MUTO,A.MATSUMOTO,AUTH 3 H.WATARAI,K.OGAMI,T.TAHARA,T.KATO,H.MIYAZAKI,AUTH 4 R.KUROKITITL STRUCTURE OF THE RECEPTOR-BINDING DOMAIN OF HUMANTITL 2 THROMBOPOIETIN DETERMINED BY COMPLEXATION WITH ATITL 3 NEUTRALIZING ANTIBODY FRAGMENTREF PROC.NATL.ACAD.SCI.USA V. 101 1816 2004REFN ISSN 0027-8424PMID 14769915DOI 10.1073/PNAS.0308530100 Variant Set Distributions Mapped […]
General Structure Information 1emo FBN1 nmr study of a pair of fibrillin ca2+ binding epidermal growth factor-like domains, 22 structures -1.0Å AUTH A.K.DOWNING,V.KNOTT,J.M.WERNER,C.M.CARDY,AUTH 2 I.D.CAMPBELL,P.A.HANDFORDTITL SOLUTION STRUCTURE OF A PAIR OF CALCIUM-BINDINGTITL 2 EPIDERMAL GROWTH FACTOR-LIKE DOMAINS: IMPLICATIONSTITL 3 FOR THE MARFAN SYNDROME AND OTHER GENETICTITL 4 DISORDERS.REF CELL(CAMBRIDGE,MASS.) V. 85 597 1996REFN ISSN 0092-8674PMID […]
General Structure Information 3tje FAS crystal structure of fas receptor extracellular domain in complex with fab e09 1.93Å AUTH M.CHODORGE,S.ZUGER,C.STIRNIMANN,C.BRIAND,L.JERMUTUS,AUTH 2 M.G.GRUTTER,R.R.MINTERTITL A SERIES OF FAS RECEPTOR AGONIST ANTIBODIES THAT DEMONSTRATETITL 2 AN INVERSE CORRELATION BETWEEN AFFINITY AND POTENCY.REF CELL DEATH DIFFER. V. 19 1187 2012REFN ISSN 1350-9047PMID 22261618DOI 10.1038/CDD.2011.208 Variant Set Distributions Mapped Variants