Assessment of Structural Intolerance and Durability
General Structure Information 1buo ZBTB16 btb domain from plzf 1.9Å AUTH K.F.AHMAD,C.K.ENGEL,G.G.PRIVETITL CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM PLZF.REF PROC.NATL.ACAD.SCI.USA V. 95 12123 1998REFN ISSN 0027-8424PMID 9770450DOI 10.1073/PNAS.95.21.12123 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f6n BPTF crystal structure of phd finger-linker-bromodomain fragment of human bptf in the free form 2.0Å AUTH H.LI,S.ILIN,W.WANG,E.M.DUNCAN,J.WYSOCKA,C.D.ALLIS,AUTH 2 D.J.PATELTITL MOLECULAR BASIS FOR SITE-SPECIFIC READ-OUT OFTITL 2 HISTONE H3K4ME3 BY THE BPTF PHD FINGER OF NURF.REF NATURE V. 442 91 2006REFN ISSN 0028-0836PMID 16728978DOI 10.1038/NATURE04802 Variant Set Distributions Mapped Variants
General Structure Information 2lvu ZBTB17 solution structure of miz-1 zinc finger 10 -1.0Å AUTH M.BEDARD,L.MALTAIS,M.E.BEAULIEU,J.BILODEAU,D.BERNARD,AUTH 2 P.LAVIGNETITL NMR STRUCTURE NOTE: SOLUTION STRUCTURE OF HUMAN MIZ-1 ZINCTITL 2 FINGERS 8 TO 10.REF J.BIOMOL.NMR V. 54 317 2012REFN ISSN 0925-2738PMID 22986688DOI 10.1007/S10858-012-9670-1 Variant Set Distributions Mapped Variants
General Structure Information 2odd RUNX1T1 solution structure of the mynd domain from aml1-eto complexed with smrt, a corepressor -1.0Å AUTH Y.LIU,W.CHEN,J.GAUDET,M.D.CHENEY,L.ROUDAIA,AUTH 2 T.CIERPICKI,R.C.KLET,K.HARTMAN,T.M.LAUE,N.A.SPECK,AUTH 3 J.H.BUSHWELLERTITL STRUCTURAL BASIS FOR RECOGNITION OF SMRT/N-COR BYTITL 2 THE MYND DOMAIN AND ITS CONTRIBUTION TO AML1/ETOSTITL 3 ACTIVITY.REF CANCER CELL V. 11 483 2007REFN ISSN 1535-6108PMID 17560331DOI 10.1016/J.CCR.2007.04.010 Variant Set […]
General Structure Information 3o34 HIST1H3H crystal structure of trim24 phd-bromo complexed with h3(13-32)k23ac peptide 1.9Å AUTH W.W.TSAI,Z.WANG,T.T.YIU,K.C.AKDEMIR,W.XIA,S.WINTER,C.Y.TSAI,AUTH 2 X.SHI,D.SCHWARZER,W.PLUNKETT,B.ARONOW,O.GOZANI,W.FISCHLE,AUTH 3 M.C.HUNG,D.J.PATEL,M.C.BARTONTITL TRIM24 LINKS A NON-CANONICAL HISTONE SIGNATURE TO BREASTTITL 2 CANCER.REF NATURE V. 468 927 2010REFN ISSN 0028-0836PMID 21164480DOI 10.1038/NATURE09542 Variant Set Distributions Mapped Variants
General Structure Information 3o34 HIST1H3J crystal structure of trim24 phd-bromo complexed with h3(13-32)k23ac peptide 1.9Å AUTH W.W.TSAI,Z.WANG,T.T.YIU,K.C.AKDEMIR,W.XIA,S.WINTER,C.Y.TSAI,AUTH 2 X.SHI,D.SCHWARZER,W.PLUNKETT,B.ARONOW,O.GOZANI,W.FISCHLE,AUTH 3 M.C.HUNG,D.J.PATEL,M.C.BARTONTITL TRIM24 LINKS A NON-CANONICAL HISTONE SIGNATURE TO BREASTTITL 2 CANCER.REF NATURE V. 468 927 2010REFN ISSN 0028-0836PMID 21164480DOI 10.1038/NATURE09542 Variant Set Distributions Mapped Variants
General Structure Information 3o34 HIST1H3D crystal structure of trim24 phd-bromo complexed with h3(13-32)k23ac peptide 1.9Å AUTH W.W.TSAI,Z.WANG,T.T.YIU,K.C.AKDEMIR,W.XIA,S.WINTER,C.Y.TSAI,AUTH 2 X.SHI,D.SCHWARZER,W.PLUNKETT,B.ARONOW,O.GOZANI,W.FISCHLE,AUTH 3 M.C.HUNG,D.J.PATEL,M.C.BARTONTITL TRIM24 LINKS A NON-CANONICAL HISTONE SIGNATURE TO BREASTTITL 2 CANCER.REF NATURE V. 468 927 2010REFN ISSN 0028-0836PMID 21164480DOI 10.1038/NATURE09542 Variant Set Distributions Mapped Variants
General Structure Information 2c6b MDM2 solution structure of the c4 zinc-finger domain of hdm2 -1.0Å AUTH G.W.YU,M.D.ALLEN,A.ANDREEVA,A.R.FERSHT,M.BYCROFTTITL SOLUTION STRUCTURE OF THE C4 ZINC FINGER DOMAIN OFTITL 2 HDM2.REF PROTEIN SCI. V. 15 384 2006REFN ISSN 0961-8368PMID 16385008DOI 10.1110/PS.051927306 Variant Set Distributions Mapped Variants
General Structure Information 2kna XIAP solution structure of uba domain of xiap -1.0Å AUTH S.K.HUI,M.K.TSE,Y.YANG,B.C.WONG,K.H.SZETITL BACKBONE AND SIDE-CHAIN 1H, 13C AND 15N ASSIGNMENTS OF THETITL 2 UBIQUITIN-ASSOCIATED DOMAIN OF HUMAN X-LINKED INHIBITOR OFTITL 3 APOPTOSIS PROTEINREF BIOMOL.NMR ASSIGN. V. 4 13 2010REFN ISSN 1874-2718PMID 19916060DOI 10.1007/S12104-009-9197-X Variant Set Distributions Mapped Variants
General Structure Information 1c9q XIAP average nmr solution structure of the bir-2 domain of xiap -1.0Å AUTH C.SUN,M.CAI,A.H.GUNASEKERA,R.P.MEADOWS,H.WANG,AUTH 2 J.CHEN,H.ZHANG,W.WU,N.XU,S.C.NG,S.W.FESIKTITL NMR STRUCTURE AND MUTAGENESIS OF THETITL 2 INHIBITOR-OF-APOPTOSIS PROTEIN XIAP.REF NATURE V. 401 818 1999REFN ISSN 0028-0836PMID 10548111DOI 10.1038/44617 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants