Assessment of Structural Intolerance and Durability
General Structure Information 3g81 SFTPD crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with alpha methyl mannoside 1.8Å AUTH E.CROUCH,K.HARTSHORN,T.HORLACHER,B.MCDONALD,K.SMITH,AUTH 2 T.CAFARELLA,B.SEATON,P.H.SEEBERGER,J.HEADTITL RECOGNITION OF MANNOSYLATED LIGANDS AND INFLUENZA A VIRUS BYTITL 2 HUMAN SURFACTANT PROTEIN D: CONTRIBUTIONS OF AN EXTENDEDTITL 3 SITE AND RESIDUE 343.REF BIOCHEMISTRY […]
General Structure Information 3qs9 FLT3 crystal structure of a human flt3 ligand-receptor ternary complex 7.8Å AUTH K.VERSTRAETE,G.VANDRIESSCHE,M.JANUAR,J.ELEGHEERT,AUTH 2 A.V.SHKUMATOV,A.DESFOSSES,K.VAN CRAENENBROECK,D.I.SVERGUN,AUTH 3 I.GUTSCHE,B.VERGAUWEN,S.N.SAVVIDESTITL STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR ASSEMBLY OF THETITL 2 HEMATOPOIETIC FLT3 SIGNALING COMPLEX.REF BLOOD V. 118 60 2011REFN ISSN 0006-4971PMID 21389326DOI 10.1182/BLOOD-2011-01-329532 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1emo FBN1 nmr study of a pair of fibrillin ca2+ binding epidermal growth factor-like domains, 22 structures -1.0Å AUTH A.K.DOWNING,V.KNOTT,J.M.WERNER,C.M.CARDY,AUTH 2 I.D.CAMPBELL,P.A.HANDFORDTITL SOLUTION STRUCTURE OF A PAIR OF CALCIUM-BINDINGTITL 2 EPIDERMAL GROWTH FACTOR-LIKE DOMAINS: IMPLICATIONSTITL 3 FOR THE MARFAN SYNDROME AND OTHER GENETICTITL 4 DISORDERS.REF CELL(CAMBRIDGE,MASS.) V. 85 597 1996REFN ISSN 0092-8674PMID […]
General Structure Information 3cki TIMP3 crystal structure of the tace-n-timp-3 complex 2.3Å AUTH M.WISNIEWSKA,P.GOETTIG,K.MASKOS,E.BELOUSKI,AUTH 2 D.WINTERS,R.HECHT,R.BLACK,W.BODETITL STRUCTURAL DETERMINANTS OF THE ADAM INHIBITION BYTITL 2 TIMP-3: CRYSTAL STRUCTURE OF THE TACE-N-TIMP-3TITL 3 COMPLEX.REF J.MOL.BIOL. V. 381 1307 2008REFN ISSN 0022-2836PMID 18638486DOI 10.1016/J.JMB.2008.06.088 Variant Set Distributions Mapped Variants
General Structure Information 3n3f COL15A1 crystal structure of the human collagen xv trimerization domain: a potent trimerizing unit common to multiplexin collagens 2.0Å AUTH J.A.WIRZ,S.P.BOUDKO,T.F.LERCH,M.S.CHAPMAN,H.P.BACHINGERTITL CRYSTAL STRUCTURE OF THE HUMAN COLLAGEN XV TRIMERIZATIONTITL 2 DOMAIN: A POTENT TRIMERIZING UNIT COMMON TO MULTIPLEXINTITL 3 COLLAGENS.REF MATRIX BIOL. V. 30 9 2011REFN ISSN 0945-053XPMID 20932905DOI 10.1016/J.MATBIO.2010.09.005 Variant […]
General Structure Information 1bnl COL18A1 zinc dependent dimers observed in crystals of human endostatin 2.9Å AUTH Y.H.DING,K.JAVAHERIAN,K.M.LO,R.CHOPRA,T.BOEHM,AUTH 2 J.LANCIOTTI,B.A.HARRIS,Y.LI,R.SHAPIRO,E.HOHENESTER,AUTH 3 R.TIMPL,J.FOLKMAN,D.C.WILEYTITL ZINC-DEPENDENT DIMERS OBSERVED IN CRYSTALS OFTITL 2 HUMAN ENDOSTATIN.REF PROC.NATL.ACAD.SCI.USA V. 95 10443 1998REFN ISSN 0027-8424PMID 9724722DOI 10.1073/PNAS.95.18.10443 Variant Set Distributions Mapped Variants
General Structure Information 2uur COL9A1 n-terminal nc4 domain of collagen ix 1.8Å AUTH V.-M.LEPPANEN,H.TOSSAVAINEN,P.PERMI,L.LEHTIO,AUTH 2 G.RONNHOLM,A.GOLDMAN,I.KILPELAINEN,T.PIHLAJAMAATITL CRYSTAL STRUCTURE OF THE N-TERMINAL NC4 DOMAIN OFTITL 2 COLLAGEN IX, A ZINC BINDING MEMBER OF THE LAMININ-TITL 3 NEUREXIN-SEX HORMONE BINDING GLOBULIN (LNS) DOMAINTITL 4 FAMILY.REF J.BIOL.CHEM. V. 282 23219 2007REFN ISSN 0021-9258PMID 17553797DOI 10.1074/JBC.M702514200 Variant Set Distributions […]
General Structure Information 2rbl TNC high resolution design of a protein loop 2.1Å AUTH X.HU,H.WANG,H.KE,B.KUHLMANTITL HIGH-RESOLUTION DESIGN OF A PROTEIN LOOP.REF PROC.NATL.ACAD.SCI.USA V. 104 17668 2007REFN ISSN 0027-8424PMID 17971437DOI 10.1073/PNAS.0707977104 Variant Set Distributions Mapped Variants
General Structure Information 2v5y PTPRM crystal structure of the receptor protein tyrosine phosphatase mu ectodomain 3.1Å AUTH A.R.ARICESCU,C.SIEBOLD,K.CHOUDHURI,V.T.CHANG,W.LU,S.J.DAVIS,AUTH 2 P.A.VAN DER MERWE,E.Y.JONESTITL STRUCTURE OF A TYROSINE PHOSPHATASE ADHESIVE INTERACTIONTITL 2 REVEALS A SPACER-CLAMP MECHANISM.REF SCIENCE V. 317 1217 2007REFN ISSN 0036-8075PMID 17761881DOI 10.1126/SCIENCE.1144646 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4h1y NT5E human ecto-5-nucleotidase (cd73): crystal form ii (open) in complex with psb11552 1.58Å AUTH K.KNAPP,M.ZEBISCH,J.PIPPEL,A.EL-TAYEB,C.E.MULLER,N.STRATERTITL CRYSTAL STRUCTURE OF THE HUMAN ECTO-5-NUCLEOTIDASE (CD73):TITL 2 INSIGHTS INTO THE REGULATION OF PURINERGIC SIGNALING.REF STRUCTURE V. 20 2161 2012REFN ISSN 0969-2126PMID 23142347DOI 10.1016/J.STR.2012.10.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants