Assessment of Structural Intolerance and Durability
General Structure Information 2c6y FOXK2 crystal structure of interleukin enhancer-binding factor 1 bound to dna 2.4Å AUTH K.-L.TSAI,C.-Y.HUANG,C.-H.CHANG,Y.-J.SUN,AUTH 2 W.-J.CHUANG,C.-D.HSIAOTITL CRYSTAL STRUCTURE OF THE HUMAN FOXK1A-DNA COMPLEXTITL 2 AND ITS IMPLICATIONS ON THE DIVERSE BINDINGTITL 3 SPECIFICITY OF WINGED HELIX/FORKHEAD PROTEINS.REF J.BIOL.CHEM. V. 281 17400 2006REFN ISSN 0021-9258PMID 16624804DOI 10.1074/JBC.M600478200 Variant Set Distributions Mapped Variants
General Structure Information 1u3b APBA1 auto-inhibition mechanism of x11s/mints family scaffold proteins revealed by the closed conformation of the tandem pdz domains -1.0Å AUTH J.-F.LONG,W.FENG,R.WANG,L.-N.CHAN,F.C.IP,J.XIA,AUTH 2 N.Y.IP,M.ZHANGTITL AUTOINHIBITION OF X11/MINT SCAFFOLD PROTEINSTITL 2 REVEALED BY THE CLOSED CONFORMATION OF THE PDZTITL 3 TANDEMREF NAT.STRUCT.MOL.BIOL. V. 12 722 2005REFN ISSN 1545-9993PMID 16007100DOI 10.1038/NSMB958 Variant Set Distributions […]
General Structure Information 3h3g PTH1R crystal structure of the extracellular domain of the human parathyroid hormone receptor (pth1r) in complex with parathyroid hormone-related protein (pthrp) 1.94Å AUTH A.A.PIOSZAK,N.R.PARKER,T.J.GARDELLA,H.E.XUTITL STRUCTURAL BASIS FOR PARATHYROID HORMONE-RELATED PROTEINTITL 2 BINDING TO THE PARATHYROID HORMONE RECEPTOR AND DESIGN OFTITL 3 CONFORMATION-SELECTIVE PEPTIDES.REF J.BIOL.CHEM. V. 284 28382 2009REFN ISSN 0021-9258PMID 19674967DOI […]
General Structure Information 1pdr DLG1 crystal structure of the third pdz domain from the human homolog of discs large protein 2.8Å AUTH J.H.MORAIS CABRAL,C.PETOSA,M.J.SUTCLIFFE,S.RAZA,AUTH 2 O.BYRON,F.POY,S.M.MARFATIA,A.H.CHISHTI,AUTH 3 R.C.LIDDINGTONTITL CRYSTAL STRUCTURE OF A PDZ DOMAIN.REF NATURE V. 382 649 1996REFN ISSN 0028-0836PMID 8757139DOI 10.1038/382649A0 Variant Set Distributions Mapped Variants
General Structure Information 2y4t DNAJC3 crystal structure of the human co-chaperone p58(ipk) 3.0Å AUTH M.SVARD,E.I.BITEROVA,J.-M.BOURHIS,J.E.GUYTITL THE CRYSTAL STRUCTURE OF THE HUMAN CO-CHAPERONE P58IPKREF PLOS ONE V. 6 22337 2011REFN ISSN 1932-6203PMID 21799829DOI 10.1371/JOURNAL.PONE.0022337 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ce8 TLE1 an eh1 peptide bound to the groucho-tle wd40 domain. 2.03Å AUTH B.H.JENNINGS,L.M.PICKLES,S.M.WAINWRIGHT,S.M.ROE,L.H.PEARL,AUTH 2 D.ISH-HOROWICZTITL MOLECULAR RECOGNITION OF TRANSCRIPTIONAL REPRESSOR MOTIFSTITL 2 BY THE WD DOMAIN OF THE GROUCHO/TLE COREPRESSOR.REF MOL.CELL V. 22 645 2006REFN ISSN 1097-2765PMID 16762837DOI 10.1016/J.MOLCEL.2006.04.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1x4g TIAL1 solution structure of rrm domain in nucleolysin tiar -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF RRM DOMAIN IN NUCLEOLYSINTITL 2 TIARREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1aw0 ATP7A fourth metal-binding domain of the menkes copper- transporting atpase, nmr, 20 structures -1.0Å AUTH J.GITSCHIER,B.MOFFAT,D.REILLY,W.I.WOOD,AUTH 2 W.J.FAIRBROTHERTITL SOLUTION STRUCTURE OF THE FOURTH METAL-BINDINGTITL 2 DOMAIN FROM THE MENKES COPPER-TRANSPORTING ATPASE.REF NAT.STRUCT.BIOL. V. 5 47 1998REFN ISSN 1072-8368PMID 9437429DOI 10.1038/NSB0198-47 Variant Set Distributions Mapped Variants
General Structure Information 1n52 NCBP1 cap binding complex 2.11Å AUTH G.CALERO,K.WILSON,T.LY,J.RIOS-STEINER,J.CLARDY,R.CERIONETITL STRUCTURAL BASIS OF M7GPPPG BINDING TO THE NUCLEARTITL 2 CAP-BINDING PROTEIN COMPLEX.REF NAT.STRUCT.BIOL. V. 9 912 2002REFN ISSN 1072-8368PMID 12434151DOI 10.1038/NSB874 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dbj MERTK solution structures of the fn3 domain of human proto- oncogene tyrosine-protein kinase mer precursor -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MERTITL 3 PRECURSORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]