Assessment of Structural Intolerance and Durability
General Structure Information 3n1p IHH crystal structure of ihhn bound to bocfn3 2.7Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n1p IHH crystal structure of ihhn bound to bocfn3 2.7Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n1p IHH crystal structure of ihhn bound to bocfn3 2.7Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n1p IHH crystal structure of ihhn bound to bocfn3 2.7Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n1p IHH crystal structure of ihhn bound to bocfn3 2.7Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n1p IHH crystal structure of ihhn bound to bocfn3 2.7Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n1p IHH crystal structure of ihhn bound to bocfn3 2.7Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vr2 DPYS human dihydropyrimidinase 2.8Å AUTH M.WELIN,T.KARLBERG,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,AUTH 3 A.FLORES,S.GRASLUND,M.HAMMARSTROM,M.D.HERMAN,I.JOHANSSON,AUTH 4 A.KALLAS,T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,L.SVENSSON,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WIKSTROM,P.NORDLUNDTITL THE CRYSTAL STRUCTURE OF HUMAN DIHYDROPYRIMIDINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vr2 DPYS human dihydropyrimidinase 2.8Å AUTH M.WELIN,T.KARLBERG,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,AUTH 3 A.FLORES,S.GRASLUND,M.HAMMARSTROM,M.D.HERMAN,I.JOHANSSON,AUTH 4 A.KALLAS,T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,L.SVENSSON,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WIKSTROM,P.NORDLUNDTITL THE CRYSTAL STRUCTURE OF HUMAN DIHYDROPYRIMIDINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vr2 DPYS human dihydropyrimidinase 2.8Å AUTH M.WELIN,T.KARLBERG,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,AUTH 3 A.FLORES,S.GRASLUND,M.HAMMARSTROM,M.D.HERMAN,I.JOHANSSON,AUTH 4 A.KALLAS,T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,L.SVENSSON,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WIKSTROM,P.NORDLUNDTITL THE CRYSTAL STRUCTURE OF HUMAN DIHYDROPYRIMIDINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants