Assessment of Structural Intolerance and Durability
General Structure Information 4b86 MSL2 crystal structure of the msl1-msl2 complex (3.5a) 3.5Å AUTH E.HALLACLI,M.LIPP,P.GEORGIEV,C.SPIELMAN,S.CUSACK,A.AKHTAR,AUTH 2 J.KADLECTITL MSL1-MEDIATED DIMERIZATION OF THE DOSAGE COMPENSATIONTITL 2 COMPLEX IS ESSENTIAL FOR MALE X-CHROMOSOME REGULATION INTITL 3 DROSOPHILA.REF MOL.CELL V. 48 587 2012REFN ISSN 1097-2765PMID 23084835DOI 10.1016/J.MOLCEL.2012.09.014 Variant Set Distributions Mapped Variants
General Structure Information 3ray PRDM11 crystal structure of methyltransferase domain of human pr domain- containing protein 11 1.73Å AUTH A.DONG,H.ZENG,P.LOPPNAU,J.R.WALKER,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WU,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN PRTITL 2 DOMAIN-CONTAINING PROTEIN 11REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2r3a SUV39H2 methyltransferase domain of human suppressor of variegation 3-9 homolog 2 2.0Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4iej DMAP1 crystal structure of a dna methyltransferase 1 associated protein 1 (dmap1) from homo sapiens at 1.45 a resolution 1.45Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGYTITL CRYSTAL STRUCTURE OF A DNA METHYLTRANSFERASE 1 ASSOCIATEDTITL 2 PROTEIN 1 (DMAP1) FROM HOMO SAPIENS AT 1.45 A RESOLUTIONREF […]
General Structure Information 3b7b EHMT1 euhmt1 (glp) ankyrin repeat domain (structure 1) 2.99Å AUTH R.E.COLLINS,J.P.NORTHROP,J.R.HORTON,D.Y.LEE,AUTH 2 X.ZHANG,M.R.STALLCUP,X.CHENGTITL THE ANKYRIN REPEATS OF G9A AND GLP HISTONETITL 2 METHYLTRANSFERASES ARE MONO- AND DIMETHYLLYSINETITL 3 BINDING MODULESREF NAT.STRUCT.MOL.BIOL. V. 15 245 2008REFN ISSN 1545-9993PMID 18264113DOI 10.1038/NSMB.1384 Variant Set Distributions Mapped Variants
General Structure Information 3f9y SETD8 structural insights into lysine multiple methylation by set domain methyltransferases, set8-y334f / h4-lys20me1 / adohcy 1.5Å AUTH J.F.COUTURE,L.M.DIRK,J.S.BRUNZELLE,R.L.HOUTZ,R.C.TRIEVELTITL STRUCTURAL ORIGINS FOR THE PRODUCT SPECIFICITY OF SET DOMAINTITL 2 PROTEIN METHYLTRANSFERASES.REF PROC.NATL.ACAD.SCI.USA V. 105 20659 2008REFN ISSN 0027-8424PMID 19088188DOI 10.1073/PNAS.0806712105 Variant Set Distributions Mapped Variants
General Structure Information 2rfi EHMT1 crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and dimethylated h3k9 peptide 1.59Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4hpl PCGF1 pcgf1 ub fold (rawul)/bcor pufd complex 2.0Å AUTH S.E.JUNCO,R.WANG,J.C.GAIPA,A.B.TAYLOR,V.SCHIRF,M.D.GEARHART,AUTH 2 V.J.BARDWELL,B.DEMELER,P.J.HART,C.A.KIMTITL STRUCTURE OF THE POLYCOMB GROUP PROTEIN PCGF1 IN COMPLEXTITL 2 WITH BCOR REVEALS BASIS FOR BINDING SELECTIVITY OF PCGFTITL 3 HOMOLOGS.REF STRUCTURE V. 21 665 2013REFN ISSN 0969-2126PMID 23523425DOI 10.1016/J.STR.2013.02.013 Variant Set Distributions Mapped Variants
General Structure Information 3ewf HDAC8 crystal structure analysis of human hdac8 h143a variant complexed with substrate. 2.5Å AUTH D.P.DOWLING,S.L.GANTT,S.G.GATTIS,C.A.FIERKE,AUTH 2 D.W.CHRISTIANSONTITL STRUCTURAL STUDIES OF HUMAN HISTONE DEACETYLASE 8TITL 2 AND ITS SITE-SPECIFIC VARIANTS COMPLEXED WITHTITL 3 SUBSTRATE AND INHIBITORS.REF BIOCHEMISTRY V. 47 13554 2008REFN ISSN 0006-2960PMID 19053282DOI 10.1021/BI801610C Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 3ut1 L3MBTL3 crystal structure of the 3-mbt repeat domain of l3mbtl3 2.05Å AUTH N.ZHONG,W.TEMPEL,A.K.WERNIMONT,S.GRASLUND,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,P.J.BROWNTITL CRYSTAL STRUCTURE OF THE 3-MBT REPEAT DOMAIN OF L3MBTL3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants