Assessment of Structural Intolerance and Durability
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2j2s KMT2A solution structure of the nonmethyl-cpg-binding cxxc domain of the leukaemia-associated mll histone methyltransferase -1.0Å AUTH M.D.ALLEN,C.G.GRUMMITT,C.HILCENKO,S.Y.MIN,AUTH 2 L.M.TONKIN,C.M.JOHNSON,S.M.FREUND,M.BYCROFT,AUTH 3 A.J.WARRENTITL SOLUTION STRUCTURE OF THE NONMETHYL-CPG-BINDINGTITL 2 CXXC DOMAIN OF THE LEUKAEMIA-ASSOCIATED MLLTITL 3 HISTONE METHYLTRANSFERASEREF EMBO J. V. 25 4503 2006REFN ISSN 0261-4189PMID 16990798DOI 10.1038/SJ.EMBOJ.7601340 Variant Set Distributions Mapped Variants
General Structure Information 4b4c CHD1 crystal structure of the dna-binding domain of human chd1. 1.62Å AUTH C.K.ALLERSTON,C.D.O.COOPER,L.SHRESTHA,M.VOLLMAR,AUTH 2 N.BURGESS-BROWN,W.W.YUE,E.P.CARPENTER,C.H.ARROWSMITH,AUTH 3 A.EDWARDS,C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMAN CHD1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dm1 CBX3 crystal structure of the complex of human chromobox homolog 3 (cbx3) with peptide 2.4Å AUTH J.RUAN,H.OUYANG,M.F.AMAYA,M.RAVICHANDRAN,P.LOPPNAU,J.MIN,AUTH 2 J.ZANGTITL STRUCTURAL BASIS OF THE CHROMODOMAIN OF CBX3 BOUND TOTITL 2 METHYLATED PEPTIDES FROM HISTONE H1 AND G9A.REF PLOS ONE V. 7 35376 2012REFN ESSN 1932-6203PMID 22514736DOI 10.1371/JOURNAL.PONE.0035376 Variant Set Distributions Mapped Variants
General Structure Information 3waa HIST4H4 the nucleosome containing human h2a.z.2 3.2Å AUTH N.HORIKOSHI,K.SATO,K.SHIMADA,Y.ARIMURA,A.OSAKABE,AUTH 2 H.TACHIWANA,Y.HAYASHI-TAKANAKA,W.IWASAKI,W.KAGAWA,M.HARATA,AUTH 3 H.KIMURA,H.KURUMIZAKATITL STRUCTURAL POLYMORPHISM IN THE L1 LOOP REGIONS OF HUMANTITL 2 H2A.Z.1 AND H2A.Z.2REF ACTA CRYSTALLOGR.,SECT.D V. 69 2431 2013REFN ISSN 0907-4449PMID 24311584DOI 10.1107/S090744491302252X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants