Assessment of Structural Intolerance and Durability
General Structure Information 2c6u CLEC1B crystal structure of human clec-2 (clec1b) 1.6Å AUTH A.A.WATSON,J.BROWN,K.HARLOS,J.A.EBLE,T.S.WALTER,AUTH 2 C.A.OCALLAGHANTITL THE CRYSTAL STRUCTURE AND MUTATIONAL BINDINGTITL 2 ANALYSIS OF THE EXTRACELLULAR DOMAIN OF THETITL 3 PLATELET-ACTIVATING RECEPTOR CLEC-2.REF J.BIOL.CHEM. V. 282 3165 2007REFN ISSN 0021-9258PMID 17132623DOI 10.1074/JBC.M610383200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3wh2 CLEC4E human mincle in complex with citrate 1.3Å AUTH A.FURUKAWA,J.KAMISHIKIRYO,D.MORI,K.TOYONAGA,Y.OKABE,A.TOJI,AUTH 2 R.KANDA,Y.MIYAKE,T.OSE,S.YAMASAKI,K.MAENAKATITL STRUCTURAL ANALYSIS FOR GLYCOLIPID RECOGNITION BY THE C-TYPETITL 2 LECTINS MINCLE AND MCLREF PROC.NATL.ACAD.SCI.USA V. 110 17438 2013REFN ISSN 0027-8424PMID 24101491DOI 10.1073/PNAS.1312649110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1k9i CD209 complex of dc-sign and glcnac2man3 2.5Å AUTH H.FEINBERG,D.A.MITCHELL,K.DRICKAMER,W.I.WEISTITL STRUCTURAL BASIS FOR SELECTIVE RECOGNITION OFTITL 2 OLIGOSACCHARIDES BY DC-SIGN AND DC-SIGNR.REF SCIENCE V. 294 2163 2001REFN ISSN 0036-8075PMID 11739956DOI 10.1126/SCIENCE.1066371 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1sl6 CLEC4M crystal structure of a fragment of dc-signr (containg the carbohydrate recognition domain and two repeats of the neck) complexed with lewis-x. 2.25Å AUTH Y.GUO,H.FEINBERG,E.CONROY,D.A.MITCHELL,R.ALVAREZ,AUTH 2 O.BLIXT,M.E.TAYLOR,W.I.WEIS,K.DRICKAMERTITL STRUCTURAL BASIS FOR DISTINCT LIGAND-BINDING ANDTITL 2 TARGETING PROPERTIES OF THE RECEPTORS DC-SIGN ANDTITL 3 DC-SIGNRREF NAT.STRUCT.MOL.BIOL. V. 11 591 2004REFN ISSN 1545-9993PMID 15195147DOI […]
General Structure Information 1kcg ULBP3 nkg2d in complex with ulbp3 2.6Å AUTH S.RADAEV,B.ROSTRO,A.G.BROOKS,M.COLONNA,P.D.SUNTITL CONFORMATIONAL PLASTICITY REVEALED BY THETITL 2 COCRYSTAL STRUCTURE OF NKG2D AND ITS CLASS ITITL 3 MHC-LIKE LIGAND ULBP3.REF IMMUNITY V. 15 1039 2001REFN ISSN 1074-7613PMID 11754823DOI 10.1016/S1074-7613(01)00241-2 Variant Set Distributions Mapped Variants
General Structure Information 2kv3 REG4 human regenerating gene type iv (reg iv) protein, p91s mutant -1.0Å AUTH M.HO,Y.LOU,S.WEI,S.LUO,W.LIN,P.LYU,C.CHENTITL HUMAN REGIV PROTEIN ADOPTS A TYPICAL C-TYPE LECTIN FOLD BUTTITL 2 BINDS MANNAN WITH TWO CALCIUM-INDEPENDENT SITESREF J.MOL.BIOL. 2010REFN ESSN 1089-8638DOI 10.1016/J.JMB.2010.07.061 Variant Set Distributions Mapped Variants
General Structure Information 3whd CLEC4D c-type lectin, human mcl 2.29Å AUTH A.FURUKAWA,J.KAMISHIKIRYO,D.MORI,K.TOYONAGA,Y.OKABE,A.TOJI,AUTH 2 R.KANDA,Y.MIYAKE,T.OSE,S.YAMASAKI,K.MAENAKATITL STRUCTURAL ANALYSIS FOR GLYCOLIPID RECOGNITION BY THE C-TYPETITL 2 LECTINS MINCLE AND MCLREF PROC.NATL.ACAD.SCI.USA V. 110 17438 2013REFN ISSN 0027-8424PMID 24101491DOI 10.1073/PNAS.1312649110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3wbp CLEC4C crystal structure of carbohydrate recognition domain of blood dendritic cell antigen-2 (bdca2) lectin (crystal form-1) 1.8Å AUTH M.NAGAE,A.IKEDA,Y.KITAGO,N.MATSUMOTO,K.YAMAMOTO,Y.YAMAGUCHITITL CRYSTAL STRUCTURES OF CARBOHYDRATE RECOGNITION DOMAIN OFTITL 2 BLOOD DENDRITIC CELL ANTIGEN-2 (BDCA2) REVEAL A COMMONTITL 3 DOMAIN-SWAPPED DIMERREF PROTEINS 2013REFN ESSN 1097-0134PMID 24425442DOI 10.1002/PROT.24504 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2ox8 COLEC12 human scavenger receptor c-type lectin carbohydrate- recognition domain. 2.5Å AUTH H.FEINBERG,M.E.TAYLOR,W.I.WEISTITL SCAVENGER RECEPTOR C-TYPE LECTIN BINDS TO THETITL 2 LEUKOCYTE CELL SURFACE GLYCAN LEWIS(X) BY A NOVELTITL 3 MECHANISM.REF J.BIOL.CHEM. V. 282 17250 2007REFN ISSN 0021-9258PMID 17420244DOI 10.1074/JBC.M701624200 Variant Set Distributions Mapped Variants
General Structure Information 3vpp CLEC9A crystal structure of the human clec9a c-type lectin-like domain 1.64Å AUTH J.G.ZHANG,P.E.CZABOTAR,A.N.POLICHENI,I.CAMINSCHI,S.S.WAN,AUTH 2 S.KITSOULIS,K.M.TULLETT,A.Y.ROBIN,R.BRAMMANANTH,AUTH 3 M.F.VAN DELFT,J.LU,L.A.OREILLY,E.C.JOSEFSSON,B.T.KILE,AUTH 4 W.J.CHIN,J.D.MINTERN,M.A.OLSHINA,W.WONG,J.BAUM,M.D.WRIGHT,AUTH 5 D.C.HUANG,N.MOHANDAS,R.L.COPPEL,P.M.COLMAN,N.A.NICOLA,AUTH 6 K.SHORTMAN,M.H.LAHOUDTITL THE DENDRITIC CELL RECEPTOR CLEC9A BINDS DAMAGED CELLS VIATITL 2 EXPOSED ACTIN FILAMENTS.REF IMMUNITY V. 36 646 2012REFN ISSN 1074-7613PMID 22483802DOI 10.1016/J.IMMUNI.2012.03.009 Variant Set Distributions Mapped Variants