Assessment of Structural Intolerance and Durability
General Structure Information 3ud1 ANK1 crystal structure of zu5a-zu5b domains of human erythrocyte ankyrin 2.0Å AUTH M.YASUNAGA,J.J.IPSARO,A.MONDRAGONTITL STRUCTURALLY SIMILAR BUT FUNCTIONALLY DIVERSE ZU5 DOMAINS INTITL 2 HUMAN ERYTHROCYTE ANKYRIN.REF J.MOL.BIOL. V. 417 336 2012REFN ISSN 0022-2836PMID 22310050DOI 10.1016/J.JMB.2012.01.041 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3kbt SPTB crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (zu5-ank) 2.75Å AUTH J.J.IPSARO,A.MONDRAGONTITL STRUCTURAL BASIS FOR SPECTRIN RECOGNITION BY ANKYRIN.REF BLOOD V. 115 4093 2010REFN ISSN 0006-4971PMID 20101027DOI 10.1182/BLOOD-2009-11-255604 Variant Set Distributions Ripley’s K […]
General Structure Information 2aze RB1 structure of the rb c-terminal domain bound to an e2f1-dp1 heterodimer 2.55Å AUTH S.M.RUBIN,A.L.GALL,N.ZHENG,N.P.PAVLETICHTITL STRUCTURE OF THE RB C-TERMINAL DOMAIN BOUND TOTITL 2 E2F1-DP1: A MECHANISM FOR PHOSPHORYLATION-INDUCEDTITL 3 E2F RELEASE.REF CELL(CAMBRIDGE,MASS.) V. 123 1093 2005REFN ISSN 0092-8674PMID 16360038DOI 10.1016/J.CELL.2005.09.044 Variant Set Distributions Mapped Variants
General Structure Information 3vi4 ITGA5 crystal structure of alpha5beta1 integrin headpiece in complex with rgd peptide 2.9Å AUTH M.NAGAE,S.RE,E.MIHARA,T.NOGI,Y.SUGITA,J.TAKAGITITL CRYSTAL STRUCTURE OF ALPHA5BETA1 INTEGRIN ECTODOMAIN: ATOMICTITL 2 DETAILS OF THE FIBRONECTIN RECEPTORREF J.CELL BIOL. V. 197 131 2012REFN ISSN 0021-9525PMID 22451694DOI 10.1083/JCB.201111077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2ha1 FN1 complex of the first and second type iii domains of human fibronectin in solution -1.0Å AUTH I.VAKONAKIS,D.STAUNTON,L.M.ROONEY,I.D.CAMPBELLTITL INTERDOMAIN ASSOCIATION IN FIBRONECTIN: INSIGHTTITL 2 INTO CRYPTIC SITES AND FIBRILLOGENESIS.REF EMBO J. V. 26 2575 2007REFN ISSN 0261-4189PMID 17464288DOI 10.1038/SJ.EMBOJ.7601694 Variant Set Distributions Mapped Variants
General Structure Information 4der TTR crystal structure of the wild type ttr binding apigenin (ttrwt:api) 1.9Å AUTH D.B.TRIVELLA,C.V.DOS REIS,L.M.LIMA,D.FOGUEL,I.POLIKARPOVTITL FLAVONOID INTERACTIONS WITH HUMAN TRANSTHYRETIN: COMBINEDTITL 2 STRUCTURAL AND THERMODYNAMIC ANALYSIS.REF J.STRUCT.BIOL. V. 180 143 2012REFN ISSN 1047-8477PMID 22842046DOI 10.1016/J.JSB.2012.07.008 Variant Set Distributions Mapped Variants
General Structure Information 3vi3 ITGB1 crystal structure of alpha5beta1 integrin headpiece (ligand-free form) 2.9Å AUTH M.NAGAE,S.RE,E.MIHARA,T.NOGI,Y.SUGITA,J.TAKAGITITL CRYSTAL STRUCTURE OF ALPHA5BETA1 INTEGRIN ECTODOMAIN: ATOMICTITL 2 DETAILS OF THE FIBRONECTIN RECEPTORREF J.CELL BIOL. V. 197 131 2012REFN ISSN 0021-9525PMID 22451694DOI 10.1083/JCB.201111077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ihb DYSF x-ray structure of the canonical c2a domain from human dysferlin 2.04Å AUTH K.FUSON,A.RICE,R.MAHLING,A.SNOW,K.NAYAK,P.SHANBHOGUE,AUTH 2 A.G.MEYER,G.M.REDPATH,A.HINDERLITER,S.T.COOPER,R.B.SUTTONTITL ALTERNATE SPLICING OF DYSFERLIN C2A CONFERS CA(2+)-DEPENDENTTITL 2 AND CA(2+)-INDEPENDENT BINDING FOR MEMBRANE REPAIR.REF STRUCTURE V. 22 104 2014REFN ISSN 0969-2126PMID 24239457DOI 10.1016/J.STR.2013.10.001 Variant Set Distributions Mapped Variants
General Structure Information 2f15 PRKAB2 glycogen-binding domain of the amp-activated protein kinase beta2 subunit 2.0Å AUTH J.R.WALKER,L.WYBENGA-GROOT,P.J.FINERTY JR.,AUTH 2 E.NEWMAN,F.M.MACKENZIE,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.ARROWSMITH,A.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF THE GLYCOGEN-BINDING DOMAIN OF THETITL 2 AMP-ACTIVATED PROTEIN KINASE BETA2 SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4gul PIR study on structure and function relationships in human ferric pirin 1.8Å AUTH F.LIU,I.REHMANI,S.ESAKI,R.FU,L.CHEN,V.DE SERRANO,A.LIUTITL PIRIN IS AN IRON-DEPENDENT REDOX REGULATOR OF NF-KAPPA B.REF PROC.NATL.ACAD.SCI.USA V. 110 9722 2013REFN ISSN 0027-8424PMID 23716661DOI 10.1073/PNAS.1221743110 Variant Set Distributions Mapped Variants