Assessment of Structural Intolerance and Durability
General Structure Information 4bie MAP3K5 crystal structures of ask1-inhibitor complexes 2.36Å AUTH O.SINGH,A.SHILLINGS,P.CRAGGS,I.WALL,P.ROWLAND,T.SKARZYNSKI,AUTH 2 C.I.HOBBS,P.HARDWICK,R.TANNER,M.BLUNT,D.R.WITTY,K.J.SMITHTITL CRYSTAL STRUCTURES OF ASK1-INHIBTOR COMPLEXES PROVIDE ATITL 2 PLATFORM FOR STRUCTURE BASED DRUG DESIGN.REF PROTEIN SCI. V. 22 1071 2013REFN ISSN 0961-8368PMID 23776076DOI 10.1002/PRO.2298 Variant Set Distributions Mapped Variants
General Structure Information 4bkt VHL von hippel lindau protein:elonginb:elonginc complex, in complex with (2s,4r)-n-methyl-1-[2-(3-methyl-1,2-oxazol-5-yl)ethanoyl]-4- oxidanyl-pyrrolidine-2-carboxamide 2.35Å AUTH D.M.DIAS,I.VAN MOLLE,M.G.J.BAUD,C.GALDEANO,C.F.G.C.GERALDES,AUTH 2 A.CIULLITITL IS NMR FRAGMENT SCREENING FINE-TUNED TO ASSESS DRUGGABILITYTITL 2 OF PROTEIN-PROTEIN INTERACTIONS?REF ACS MED.CHEM.LETT. V. 5 23 2014REFN ISSN 1948-5875PMID 24436777DOI 10.1021/ML400296C Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]