Assessment of Structural Intolerance and Durability
General Structure Information 4gdk ATG5 crystal structure of human atg12~atg5 conjugate in complex with an n- terminal fragment of atg16l1 2.7Å AUTH C.OTOMO,Z.METLAGEL,G.TAKAESU,T.OTOMOTITL STRUCTURE OF THE HUMAN ATG12~ATG5 CONJUGATE REQUIRED FOR LC3TITL 2 LIPIDATION IN AUTOPHAGY.REF NAT.STRUCT.MOL.BIOL. V. 20 59 2013REFN ISSN 1545-9993PMID 23202584DOI 10.1038/NSMB.2431 Variant Set Distributions Mapped Variants
General Structure Information 3vtw MAP1LC3B crystal structure of t7-tagged optineurin lir-fused human lc3b_2-119 2.52Å AUTH V.V.ROGOV,H.SUZUKI,E.FISKIN,P.WILD,A.KNISS,A.ROZENKNOP,AUTH 2 R.KATO,M.KAWASAKI,D.G.MCEWAN,F.LOHR,P.GUNTERT,I.DIKIC,AUTH 3 S.WAKATSUKI,V.DOTSCHTITL STRUCTURAL BASIS FOR PHOSPHORYLATION-TRIGGERED AUTOPHAGICTITL 2 CLEARANCE OF SALMONELLAREF BIOCHEM.J. V. 454 459 2013REFN ISSN 0264-6021PMID 23805866DOI 10.1042/BJ20121907 Variant Set Distributions Mapped Variants
General Structure Information 3vvw MAP1LC3C ndp52 in complex with lc3c 2.5Å AUTH N.V.MUHLINEN,M.AKUTSU,B.J.RAVENHILL,A.FOEGLEIN,S.BLOOR,AUTH 2 T.J.RUTHERFORD,S.M.FREUND,D.KOMANDER,F.RANDOWTITL LC3C, BOUND SELECTIVELY BY A NONCANONICAL LIR MOTIF INTITL 2 NDP52, IS REQUIRED FOR ANTIBACTERIAL AUTOPHAGYREF MOL.CELL V. 48 329 2012REFN ISSN 1097-2765PMID 23022382DOI 10.1016/J.MOLCEL.2012.08.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2r2q GABARAPL1 crystal structure of human gamma-aminobutyric acid receptor- associated protein-like 1 (gabarap1), isoform cra_a 1.65Å AUTH R.PARAMANATHAN,T.DAVIS,W.TEMPEL,S.MUJIB,AUTH 2 C.BUTLER-COLE,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF HUMAN GAMMA-AMINOBUTYRIC ACIDTITL 2 RECEPTOR-ASSOCIATED PROTEIN-LIKE 1 (GABARAP1),TITL 3 ISOFORM CRA_A.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2p82 ATG4A cysteine protease atg4a 2.1Å AUTH J.R.WALKER,T.DAVIS,S.MUJIB,C.BUTLER-COLE,P.J.FINERTY JR.,AUTH 2 J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL HUMAN CYSTEINE PROTEASE ATG4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ddp BECN1 crystal structure of beclin 1 evolutionarily conserved domain(ecd) 1.55Å AUTH W.HUANG,W.CHOI,W.HU,N.MI,Q.GUO,M.MA,M.LIU,Y.TIAN,P.LU,AUTH 2 F.L.WANG,H.DENG,L.LIU,N.GAO,L.YU,Y.SHITITL CRYSTAL STRUCTURE AND BIOCHEMICAL ANALYSES REVEAL BECLIN 1TITL 2 AS A NOVEL MEMBRANE BINDING PROTEINREF CELL RES. 2012REFN ISSN 1001-0602PMID 22310240DOI 10.1038/CR.2012.24 Variant Set Distributions Mapped Variants
General Structure Information 2pon BCL2L1 solution structure of the bcl-xl/beclin-1 complex -1.0Å AUTH W.FENG,S.HUANG,H.WU,M.ZHANGTITL MOLECULAR BASIS OF BCL-XLS TARGET RECOGNITIONTITL 2 VERSATILITY REVEALED BY THE STRUCTURE OF BCL-XL INTITL 3 COMPLEX WITH THE BH3 DOMAIN OF BECLIN-1.REF J.MOL.BIOL. V. 372 223 2007REFN ISSN 0022-2836PMID 17659302DOI 10.1016/J.JMB.2007.06.069 Variant Set Distributions Mapped Variants
General Structure Information 3vvw CALCOCO2 ndp52 in complex with lc3c 2.5Å AUTH N.V.MUHLINEN,M.AKUTSU,B.J.RAVENHILL,A.FOEGLEIN,S.BLOOR,AUTH 2 T.J.RUTHERFORD,S.M.FREUND,D.KOMANDER,F.RANDOWTITL LC3C, BOUND SELECTIVELY BY A NONCANONICAL LIR MOTIF INTITL 2 NDP52, IS REQUIRED FOR ANTIBACTERIAL AUTOPHAGYREF MOL.CELL V. 48 329 2012REFN ISSN 1097-2765PMID 23022382DOI 10.1016/J.MOLCEL.2012.08.024 Variant Set Distributions Mapped Variants
General Structure Information 3vvw CALCOCO2 ndp52 in complex with lc3c 2.5Å AUTH N.V.MUHLINEN,M.AKUTSU,B.J.RAVENHILL,A.FOEGLEIN,S.BLOOR,AUTH 2 T.J.RUTHERFORD,S.M.FREUND,D.KOMANDER,F.RANDOWTITL LC3C, BOUND SELECTIVELY BY A NONCANONICAL LIR MOTIF INTITL 2 NDP52, IS REQUIRED FOR ANTIBACTERIAL AUTOPHAGYREF MOL.CELL V. 48 329 2012REFN ISSN 1097-2765PMID 23022382DOI 10.1016/J.MOLCEL.2012.08.024 Variant Set Distributions Mapped Variants
General Structure Information 3vvw CALCOCO2 ndp52 in complex with lc3c 2.5Å AUTH N.V.MUHLINEN,M.AKUTSU,B.J.RAVENHILL,A.FOEGLEIN,S.BLOOR,AUTH 2 T.J.RUTHERFORD,S.M.FREUND,D.KOMANDER,F.RANDOWTITL LC3C, BOUND SELECTIVELY BY A NONCANONICAL LIR MOTIF INTITL 2 NDP52, IS REQUIRED FOR ANTIBACTERIAL AUTOPHAGYREF MOL.CELL V. 48 329 2012REFN ISSN 1097-2765PMID 23022382DOI 10.1016/J.MOLCEL.2012.08.024 Variant Set Distributions Mapped Variants