Assessment of Structural Intolerance and Durability
General Structure Information 2hb8 VDR crystal structure of vdr lbd in complex with 2alpha-methyl calcitriol 2.0Å AUTH S.HOURAI,T.FUJISHIMA,A.KITTAKA,Y.SUHARA,H.TAKAYAMA,AUTH 2 N.ROCHEL,D.MORASTITL PROBING A WATER CHANNEL NEAR THE A-RING OFTITL 2 RECEPTOR-BOUND 1ALPHA,25-DIHYDROXYVITAMIN D3 WITHTITL 3 SELECTED 2ALPHA-SUBSTITUTED ANALOGUESREF J.MED.CHEM. V. 49 5199 2006REFN ISSN 0022-2623PMID 16913708DOI 10.1021/JM0604070 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4dm8 RARB crystal structure of rarb lbd in complex with 9cis retinoic acid 2.3Å AUTH J.OSZ,Y.BRELIVET,C.PELUSO-ILTIS,V.CURA,S.EILER,M.RUFF,AUTH 2 W.BOURGUET,N.ROCHEL,D.MORASTITL STRUCTURAL BASIS FOR A MOLECULAR ALLOSTERIC CONTROLTITL 2 MECHANISM OF COFACTOR BINDING TO NUCLEAR RECEPTORS.REF PROC.NATL.ACAD.SCI.USA V. 109 E588 2012REFN ISSN 0027-8424PMID 22355136DOI 10.1073/PNAS.1118192109 Variant Set Distributions Mapped Variants
General Structure Information 4j5w NR1I2 crystal structure of the apo-pxr/rxralpha lbd heterotetramer complex 2.8Å AUTH B.D.WALLACE,L.BETTS,G.TALMAGE,R.M.POLLET,N.S.HOLMAN,AUTH 2 M.R.REDINBOTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE HUMAN NUCLEARTITL 2 XENOBIOTIC RECEPTOR PXR IN COMPLEX WITH RXRALPHA.REF J.MOL.BIOL. V. 425 2561 2013REFN ISSN 0022-2836PMID 23602807DOI 10.1016/J.JMB.2013.04.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]