Assessment of Structural Intolerance and Durability
General Structure Information 2h2b TJP1 crystal structure of zo-1 pdz1 bound to a phage-derived ligand (wrrttyl) 1.6Å AUTH B.A.APPLETON,Y.ZHANG,P.WU,J.P.YIN,W.HUNZIKER,N.J.SKELTON,AUTH 2 S.S.SIDHU,C.WIESMANNTITL COMPARATIVE STRUCTURAL ANALYSIS OF THE ERBIN PDZ DOMAIN ANDTITL 2 THE FIRST PDZ DOMAIN OF ZO-1. INSIGHTS INTO DETERMINANTS OFTITL 3 PDZ DOMAIN SPECIFICITY.REF J.BIOL.CHEM. V. 281 22312 2006REFN ISSN 0021-9258PMID 16737969DOI 10.1074/JBC.M602901200 Variant […]
General Structure Information 2p3w HTRA3 crystal structure of the htra3 pdz domain bound to a phage-derived ligand (fgrwv) 1.7Å AUTH S.T.RUNYON,Y.ZHANG,B.A.APPLETON,S.L.SAZINSKY,P.WU,B.PAN,AUTH 2 C.WIESMANN,N.J.SKELTON,S.S.SIDHUTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE PDZ DOMAINS OFTITL 2 HUMAN HTRA1 AND HTRA3.REF PROTEIN SCI. V. 16 2454 2007REFN ISSN 0961-8368PMID 17962403DOI 10.1110/PS.073049407 Variant Set Distributions Mapped Variants
General Structure Information 2p3w HTRA3 crystal structure of the htra3 pdz domain bound to a phage-derived ligand (fgrwv) 1.7Å AUTH S.T.RUNYON,Y.ZHANG,B.A.APPLETON,S.L.SAZINSKY,P.WU,B.PAN,AUTH 2 C.WIESMANN,N.J.SKELTON,S.S.SIDHUTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE PDZ DOMAINS OFTITL 2 HUMAN HTRA1 AND HTRA3.REF PROTEIN SCI. V. 16 2454 2007REFN ISSN 0961-8368PMID 17962403DOI 10.1110/PS.073049407 Variant Set Distributions Mapped Variants
General Structure Information 2h2b TJP1 crystal structure of zo-1 pdz1 bound to a phage-derived ligand (wrrttyl) 1.6Å AUTH B.A.APPLETON,Y.ZHANG,P.WU,J.P.YIN,W.HUNZIKER,N.J.SKELTON,AUTH 2 S.S.SIDHU,C.WIESMANNTITL COMPARATIVE STRUCTURAL ANALYSIS OF THE ERBIN PDZ DOMAIN ANDTITL 2 THE FIRST PDZ DOMAIN OF ZO-1. INSIGHTS INTO DETERMINANTS OFTITL 3 PDZ DOMAIN SPECIFICITY.REF J.BIOL.CHEM. V. 281 22312 2006REFN ISSN 0021-9258PMID 16737969DOI 10.1074/JBC.M602901200 Variant […]
General Structure Information 2p3w HTRA3 crystal structure of the htra3 pdz domain bound to a phage-derived ligand (fgrwv) 1.7Å AUTH S.T.RUNYON,Y.ZHANG,B.A.APPLETON,S.L.SAZINSKY,P.WU,B.PAN,AUTH 2 C.WIESMANN,N.J.SKELTON,S.S.SIDHUTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE PDZ DOMAINS OFTITL 2 HUMAN HTRA1 AND HTRA3.REF PROTEIN SCI. V. 16 2454 2007REFN ISSN 0961-8368PMID 17962403DOI 10.1110/PS.073049407 Variant Set Distributions Mapped Variants
General Structure Information 3qb1 IL2 interleukin-2 mutant d10 3.1Å AUTH A.M.LEVIN,D.L.BATES,A.M.RING,C.KRIEG,J.T.LIN,L.SU,I.MORAGA,AUTH 2 M.E.RAEBER,G.R.BOWMAN,P.NOVICK,V.S.PANDE,C.G.FATHMAN,AUTH 3 O.BOYMAN,K.C.GARCIATITL EXPLOITING A NATURAL CONFORMATIONAL SWITCH TO ENGINEER ANTITL 2 INTERLEUKIN-2 SUPERKINEREF NATURE V. 484 529 2012REFN ISSN 0028-0836PMID 22446627DOI 10.1038/NATURE10975 Variant Set Distributions Mapped Variants