Assessment of Structural Intolerance and Durability
General Structure Information 2cu1 MAP3K2 solution structure of the pb1 domain of human protein kinase mekk2b -1.0Å AUTH K.INOUE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PB1 DOMAIN OF HUMANTITL 2 PROTEIN KINASE MEKK2BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1zv4 RGS17 structure of the regulator of g-protein signaling 17 (rgsz2) 2.4Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Mapped Variants
General Structure Information 2dae TAB2 solution structure of the n-terminal cue domain in the human mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (map3k7ip2) -1.0Å AUTH C.ZHAO,T.KIGAWA,M.SATO,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL CUE DOMAIN INTITL 2 THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASETITL 3 KINASE 7 INTERACTING PROTEIN 2 (MAP3K7IP2)REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2dmk MID2 the solution structure of the fn3 domain of human midline 2 protein -1.0Å AUTH N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE FN3 DOMAIN OF HUMANTITL 2 MIDLINE 2 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2csf SATB2 solution structure of the second cut domain of human satb2 -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND CUT DOMAIN OFTITL 2 HUMAN SATB2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jfl SLK crystal structure of human ste20-like kinase ( diphosphorylated form) bound to 5- amino-3-((4-( aminosulfonyl)phenyl)amino)-n-(2,6- difluorophenyl)-1h-1,2, 4-triazole-1-carbothioamide 2.2Å AUTH A.C.W.PIKE,P.RELLOS,F.H.NIESEN,A.TURNBULL,A.W.OLIVER,AUTH 2 S.A.PARKER,B.E.TURK,L.H.PEARL,S.KNAPPTITL ACTIVATION SEGMENT DIMERIZATION: A MECHANISM FOR KINASETITL 2 AUTOPHOSPHORYLATION OF NON-CONSENSUS SITES.REF EMBO J. V. 27 704 2008REFN ISSN 0261-4189PMID 18239682DOI 10.1038/EMBOJ.2008.8 Variant Set Distributions Mapped Variants
General Structure Information 2r3a SUV39H2 methyltransferase domain of human suppressor of variegation 3-9 homolog 2 2.0Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2v4u CTPS2 human ctp synthetase 2 – glutaminase domain in complex with 5-oxo-l-norleucine 2.3Å AUTH M.WELIN,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,AUTH 2 H.BERGLUND,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 A.JOHANSSON,I.JOHANSSON,T.KARLBERG,T.KOTENYOVA,AUTH 5 L.LEHTIO,M.E.NILSSON,T.NYMAN,K.OLESEN,C.PERSSON,AUTH 6 J.SAGEMARK,H.SCHUELER,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,M.WISNIEWSKA,J.WEIGELT,M.WIKSTROM,AUTH 8 P.NORDLUNDTITL HUMAN CTP SYNTHETASE 2 – GLUTAMINASE DOMAIN INTITL 2 COMPLEX WITH 5-OXO-L-NORLEUCINEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fmu SETD2 crystal structure of methyltransferase domain of human set domain- containing protein 2 compound: pr-snf 2.1Å AUTH W.ZHENG,G.IBANEZ,H.WU,G.BLUM,H.ZENG,A.DONG,F.LI,T.HAJIAN,AUTH 2 A.ALLALI-HASSANI,M.F.AMAYA,A.SIARHEYEVA,W.YU,P.J.BROWN,AUTH 3 M.SCHAPIRA,M.VEDADI,J.MIN,M.LUOTITL SINEFUNGIN DERIVATIVES AS INHIBITORS AND STRUCTURE PROBES OFTITL 2 PROTEIN LYSINE METHYLTRANSFERASE SETD2.REF J.AM.CHEM.SOC. V. 134 18004 2012REFN ISSN 0002-7863PMID 23043551DOI 10.1021/JA307060P Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2d8r THAP2 solution structure of the thap domain of the human thap domain-containing protein 2 -1.0Å AUTH K.MIYAMOTO,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THAP DOMAIN OF THE HUMANTITL 2 THAP DOMAIN-CONTAINING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants