Assessment of Structural Intolerance and Durability
General Structure Information 2iqc FANCF crystal structure of human fancf protein that functions in the assembly of a dna damage signaling complex 2.4Å AUTH P.KOWAL,A.M.GURTAN,P.STUCKERT,A.D.DANDREA,AUTH 2 T.ELLENBERGERTITL STRUCTURAL DETERMINANTS OF HUMAN FANCF PROTEINTITL 2 THAT FUNCTION IN THE ASSEMBLY OF A DNA DAMAGETITL 3 SIGNALING COMPLEX.REF J.BIOL.CHEM. V. 282 2047 2007REFN ISSN 0021-9258PMID 17082180DOI 10.1074/JBC.M608356200 […]
General Structure Information 1kqo NMNAT1 crystal structure of nmn/namn adenylyltransferase complexed with deamido-nad 2.5Å AUTH T.ZHOU,O.KURNASOV,D.R.TOMCHICK,D.D.BINNS,N.V.GRISHIN,AUTH 2 V.E.MARQUEZ,A.L.OSTERMAN,H.ZHANGTITL STRUCTURE OF HHUMAN OF NICOTINAMIDE/NICOTINIC ACIDTITL 2 MONONUCLEOTIDE ADENYLYLTRANSFERASE. BASIS FOR THE DUALTITL 3 SUBSTRATE SPECIFICITY AND ACTIVATION OF THE ONCOLYTIC AGENTTITL 4 TIAZOFURIN.REF J.BIOL.CHEM. V. 277 13148 2002REFN ISSN 0021-9258PMID 11788603DOI 10.1074/JBC.M111469200 Variant Set Distributions Ripley’s […]
General Structure Information 2dkp PLEKHA5 solution structure of the ph domain of pleckstrin homology domain-containing protein family a member 5 from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PLECKSTRINTITL 2 HOMOLOGY DOMAIN-CONTAINING PROTEIN FAMILY A MEMBERTITL 3 5 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2y9t TP63 structural basis of p63a sam domain mutants involved in aec syndrome -1.0Å AUTH A.SATHYAMURTHY,S.M.V.FREUND,C.M.JOHNSON,M.D.ALLEN,M.BYCROFTTITL STRUCTURAL BASIS OF P63ALPHA SAM DOMAIN MUTANTS INVOLVED INTITL 2 AEC SYNDROME.REF FEBS J. V. 278 2680 2011REFN ISSN 1742-464XPMID 21615690DOI 10.1111/J.1742-4658.2011.08194.X Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b7b EHMT1 euhmt1 (glp) ankyrin repeat domain (structure 1) 2.99Å AUTH R.E.COLLINS,J.P.NORTHROP,J.R.HORTON,D.Y.LEE,AUTH 2 X.ZHANG,M.R.STALLCUP,X.CHENGTITL THE ANKYRIN REPEATS OF G9A AND GLP HISTONETITL 2 METHYLTRANSFERASES ARE MONO- AND DIMETHYLLYSINETITL 3 BINDING MODULESREF NAT.STRUCT.MOL.BIOL. V. 15 245 2008REFN ISSN 1545-9993PMID 18264113DOI 10.1038/NSMB.1384 Variant Set Distributions Mapped Variants
General Structure Information 2al7 ARL8B structure of human adp-ribosylation factor-like 10c 1.85Å AUTH S.ISMAIL,S.DIMOV,A.ATANASSOVA,C.ARROWSMITH,AUTH 2 A.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARK,AUTH 3 STRUCTURAL GENOMICS CONSORTIUMTITL GTP-LIKE CONFORMATION OF GDP-BOUND ARL10C GTPASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4kgh BPIFA1 crystal structure of human splunc1 lacking the secretion signal sequence 2.81Å AUTH A.L.GARLAND,W.G.WALTON,R.D.COAKLEY,C.D.TAN,R.C.GILMORE,AUTH 2 C.A.HOBBS,A.TRIPATHY,L.A.CLUNES,S.BENCHARIT,M.J.STUTTS,AUTH 3 L.BETTS,M.R.REDINBO,R.TARRANTITL MOLECULAR BASIS FOR PH-DEPENDENT MUCOSAL DEHYDRATION INTITL 2 CYSTIC FIBROSIS AIRWAYS.REF PROC.NATL.ACAD.SCI.USA V. 110 15973 2013REFN ISSN 0027-8424PMID 24043776DOI 10.1073/PNAS.1311999110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2ve7 SPC25 crystal structure of a bonsai version of the human ndc80 complex 2.88Å AUTH C.CIFERRI,S.PASQUALATO,E.SCREPANTI,G.VARETTI,S.SANTAGUIDA,AUTH 2 G.DOS REIS,A.MAIOLICA,J.POLKA,J.G.DE LUCA,P.DE WULF,M.SALEK,AUTH 3 J.RAPPSILBER,C.A.MOORES,E.D.SALMON,A.MUSACCHIOTITL IMPLICATIONS FOR KINETOCHORE-MICROTUBULE ATTACHMENT FROMTITL 2 THE STRUCTURE OF AN ENGINEERED NDC80 COMPLEXREF CELL(CAMBRIDGE,MASS.) V. 133 427 2008REFN ISSN 0092-8674PMID 18455984DOI 10.1016/J.CELL.2008.03.020 Variant Set Distributions Mapped Variants
General Structure Information 2oid IRAK4 crystal structure of irak4 kinase domain complexed with amppnp 2.3Å AUTH A.KUGLSTATTER,A.G.VILLASENOR,D.SHAW,S.W.LEE,AUTH 2 S.TSING,L.NIU,K.W.SONG,J.W.BARNETT,M.F.BROWNERTITL CUTTING EDGE: IL-1 RECEPTOR-ASSOCIATED KINASE 4TITL 2 STRUCTURES REVEAL NOVEL FEATURES AND MULTIPLETITL 3 CONFORMATIONS.REF J.IMMUNOL. V. 178 2641 2007REFN ISSN 0022-1767PMID 17312103 Variant Set Distributions Mapped Variants
General Structure Information 4b6h DCP1A structure of hdcp1a in complex with proline rich sequence of pnrc2 2.6Å AUTH T.LAI,H.CHO,Z.LIU,M.W.BOWLER,S.PIAO,R.PARKER,Y.K.KIM,H.SONGTITL STRUCTURAL BASIS OF THE PNRC2-MEDIATED LINK BETWEEN MRNATITL 2 SURVEILLANCE AND DECAPPING.REF STRUCTURE V. 20 2025 2012REFN ISSN 0969-2126PMID 23085078DOI 10.1016/J.STR.2012.09.009 Variant Set Distributions Mapped Variants