Assessment of Structural Intolerance and Durability
General Structure Information 2lp0 HOXC9 the solution structure of homeodomain-protein complex -1.0Å AUTH B.ZHOU,C.LIU,Z.XU,G.ZHUTITL STRUCTURAL BASIS FOR HOMEODOMAIN RECOGNITION BY THETITL 2 CELL-CYCLE REGULATOR GEMININREF PROC.NATL.ACAD.SCI.USA 2012REFN ESSN 1091-6490PMID 22615398DOI 10.1073/PNAS.1200874109 Variant Set Distributions Mapped Variants
General Structure Information 2lce BCL6 chemical shift assignment of hr4436b from homo sapiens, northeast structural genomics consortium -1.0Å AUTH H.LEE,G.T.MONTELIONE,J.H.PRESTEGARDTITL SOLUTION STRUCTURE OF HR4436B.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3e2u CLIP1 crystal structure of the zink-knuckle 2 domain of human clip-170 in complex with cap-gly domain of human dynactin-1 (p150-glued) 2.6Å AUTH A.WEISBRICH,S.HONNAPPA,R.JAUSSI,O.OKHRIMENKO,D.FREY,AUTH 2 I.JELESAROV,A.AKHMANOVA,M.O.STEINMETZTITL STRUCTURE-FUNCTION RELATIONSHIP OF CAP-GLY DOMAINSREF NAT.STRUCT.MOL.BIOL. V. 14 959 2007REFN ISSN 1545-9993PMID 17828277DOI 10.1038/NSMB1291 Variant Set Distributions Mapped Variants
General Structure Information 3bim BCL6 crystal structure of the bcl6 btb domain dimer in complex with the bcor bbd corepressor peptide 2.6Å AUTH A.F.GHETU,C.M.CORCORAN,L.CERCHIETTI,V.J.BARDWELL,AUTH 2 A.MELNICK,G.G.PRIVETITL STRUCTURE OF A BCOR COREPRESSOR PEPTIDE IN COMPLEXTITL 2 WITH THE BCL6 BTB DOMAIN DIMER.REF MOL.CELL V. 29 384 2008REFN ISSN 1097-2765PMID 18280243DOI 10.1016/J.MOLCEL.2007.12.026 Variant Set Distributions Mapped Variants
General Structure Information 2cp6 CLIP1 solution structure of the 2nd cap-gly domain in human clip- 170/restin -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 2ND CAP-GLY DOMAIN INTITL 2 HUMAN CLIP-170/RESTINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1fb1 GCH1 crystal structure of human gtp cyclohydrolase i 3.1Å AUTH G.AUERBACH,A.HERRMANN,A.BRACHER,G.BADER,M.GUTLICH,M.FISCHER,AUTH 2 M.NEUKAMM,M.GARRIDO-FRANCO,J.RICHARDSON,H.NAR,R.HUBER,AUTH 3 A.BACHERTITL ZINC PLAYS A KEY ROLE IN HUMAN AND BACTERIAL GTPTITL 2 CYCLOHYDROLASE I.REF PROC.NATL.ACAD.SCI.USA V. 97 13567 2000REFN ISSN 0027-8424PMID 11087827DOI 10.1073/PNAS.240463497 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2cbz ABCC1 structure of the human multidrug resistance protein 1 nucleotide binding domain 1 1.5Å AUTH O.RAMAEN,N.LEULLIOT,C.SIZUN,N.ULRYCK,O.PAMLARD,AUTH 2 J.-Y.LALLEMAND,H.VAN TILBEURGH,E.JACQUETTITL STRUCTURE OF THE HUMAN MULTIDRUG RESISTANCETITL 2 PROTEIN 1 NUCLEOTIDE BINDING DOMAIN 1 BOUND TOTITL 3 MG(2+)/ATP REVEALS A NON-PRODUCTIVE CATALYTICTITL 4 SITE.REF J.MOL.BIOL. V. 359 940 2006REFN ISSN 0022-2836PMID 16697012DOI 10.1016/J.JMB.2006.04.005 […]
General Structure Information 3gdq HSPA1L crystal structure of the human 70kda heat shock protein 1-like atpase domain in complex with adp and inorganic phosphate 1.8Å AUTH M.WISNIEWSKA,T.KARLBERG,L.LEHTIO,I.JOHANSSON,T.KOTENYOVA,AUTH 2 M.MOCHE,H.SCHULERTITL CRYSTAL STRUCTURES OF THE ATPASE DOMAINS OF FOUR HUMAN HSP70TITL 2 ISOFORMS: HSPA1L/HSP70-HOM, HSPA2/HSP70-2, HSPA6/HSP70B,TITL 3 AND HSPA5/BIP/GRP78REF PLOS ONE V. 5 E8625 2010REFN ESSN 1932-6203PMID […]
General Structure Information 2lly CHRNA4 nmr structures of the transmembrane domains of the nachr a4 subunit -1.0Å AUTH V.BONDARENKO,D.MOWREY,T.TILLMAN,T.CUI,L.T.LIU,Y.XU,P.TANGTITL NMR STRUCTURES OF THE TRANSMEMBRANE DOMAINS OF THE A4B2TITL 2 NACHR.REF BIOCHIM.BIOPHYS.ACTA V.1818 1261 2012REFN ISSN 0006-3002PMID 22361591DOI 10.1016/J.BBAMEM.2012.02.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jxc EPS15 structure of the eps15-eh2 stonin2 complex -1.0Å AUTH J.RUMPF,B.SIMON,N.JUNG,T.MARITZEN,V.HAUCKE,M.SATTLER,AUTH 2 Y.GROEMPINGTITL STRUCTURE OF THE EPS15-STONIN2 COMPLEX PROVIDES A MOLECULARTITL 2 EXPLANATION FOR EH-DOMAIN LIGAND SPECIFICITY.REF EMBO J. V. 27 558 2008REFN ISSN 0261-4189PMID 18200045DOI 10.1038/SJ.EMBOJ.7601980 Variant Set Distributions Mapped Variants