Assessment of Structural Intolerance and Durability
General Structure Information 2aze E2F1 structure of the rb c-terminal domain bound to an e2f1-dp1 heterodimer 2.55Å AUTH S.M.RUBIN,A.L.GALL,N.ZHENG,N.P.PAVLETICHTITL STRUCTURE OF THE RB C-TERMINAL DOMAIN BOUND TOTITL 2 E2F1-DP1: A MECHANISM FOR PHOSPHORYLATION-INDUCEDTITL 3 E2F RELEASE.REF CELL(CAMBRIDGE,MASS.) V. 123 1093 2005REFN ISSN 0092-8674PMID 16360038DOI 10.1016/J.CELL.2005.09.044 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3q90 G3BP1 crystal structure of the ntf2 domain of ras gtpase-activating protein- binding protein 1 1.7Å AUTH M.WELIN,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,T.EKBLAD,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE NTF2 DOMAIN OF RASTITL 2 GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2wz1 GUCY1B3 structure of the catalytic domain of human soluble guanylate cyclase 1 beta 3. 1.63Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ISSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Mapped Variants
General Structure Information 4bs2 TARDBP nmr structure of human tdp-43 tandem rrms in complex with ug-rich rna -1.0Å AUTH P.J.LUKAVSKY,D.DAUJOTYTE,J.R.TOLLERVEY,J.ULE,C.STUANI,AUTH 2 E.BURATTI,F.E.BARALLE,F.F.DAMBERGER,F.H.T.ALLAINTITL MOLECULAR BASIS OF UG-RICH RNA RECOGNITION BY THE HUMANTITL 2 SPLICING FACTOR TDP-43REF NAT.STRUCT.MOL.BIOL. V. 20 1443 2013REFN ISSN 1545-9993PMID 24240615DOI 10.1038/NSMB.2698 Variant Set Distributions Mapped Variants
General Structure Information 2jed PRKCQ the crystal structure of the kinase domain of the protein kinase c theta in complex with nvp-xaa228 at 2.32a resolution. 2.32Å AUTH W.STARK,F.BITSCH,A.BERNER,F.BUELENS,P.GRAFF,AUTH 2 H.DEPERSIN,G.FENDRICH,M.GEISER,R.KNECHT,J.RAHUEL,AUTH 3 G.RUMMEL,J.M.SCHLAEPPI,R.SCHMITZ,A.STRAUSS,J.WAGNERTITL THE CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF THETITL 2 PROTEIN KINASE C THETA IN COMPLEX WITH NVP-XAA228REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 1sd1 MTAP structure of human 5-deoxy-5-methylthioadenosine phosphorylase complexed with formycin a 2.03Å AUTH J.E.LEE,E.C.SETTEMBRE,K.A.CORNELL,M.K.RISCOE,J.R.SUFRIN,AUTH 2 S.E.EALICK,P.L.HOWELLTITL STRUCTURAL COMPARISON OF MTA PHOSPHORYLASE AND MTA/ADOHCYTITL 2 NUCLEOSIDASE EXPLAINS SUBSTRATE PREFERENCES AND IDENTIFIESTITL 3 REGIONS EXPLOITABLE FOR INHIBITOR DESIGN.REF BIOCHEMISTRY V. 43 5159 2004REFN ISSN 0006-2960PMID 15122881DOI 10.1021/BI035492H Variant Set Distributions Mapped Variants
General Structure Information 4azm FABP5 human epidermal fatty acid-binding protein (fabp5) in complex with the inhibitor bms-309413 2.75Å AUTH B.SANSON,T.WANG,J.SUN,L.WANG,M.KACZOCHA,I.OJIMA,D.DEUTSCH,AUTH 2 H.LITITL CRYSTALLOGRAPHIC STUDY OF FABP5 AS AN INTRACELLULARTITL 2 ENDOCANNABINOID TRANSPORTER.REF ACTA CRYSTALLOGR.,SECT.D V. 70 290 2014REFN ISSN 0907-4449PMID 24531463DOI 10.1107/S1399004713026795 Variant Set Distributions Mapped Variants
General Structure Information 3g73 FOXM1 structure of the foxm1 dna binding 2.21Å AUTH D.R.LITTLER,M.ALVAREZ-FERNANDEZ,A.STEIN,R.G.HIBBERT,AUTH 2 T.HEIDEBRECHT,P.ALOY,R.H.MEDEMA,A.PERRAKISTITL STRUCTURE OF THE FOXM1 DNA-RECOGNITION DOMAIN BOUND TO ATITL 2 PROMOTER SEQUENCEREF NUCLEIC ACIDS RES. 2010REFN ESSN 1362-4962PMID 20360045DOI 10.1093/NAR/GKQ194 Variant Set Distributions Mapped Variants
General Structure Information 1qkq CLC charcot-leyden crystal protein – mannose complex 1.8Å AUTH G.J.SWAMINATHAN,D.D.LEONIDAS,M.P.SAVAGE,AUTH 2 S.J.ACKERMAN,K.R.ACHARYATITL SELECTIVE RECOGNITION OF MANNOSE BY THE HUMANTITL 2 EOSINOPHIL CHARCOT-LEYDEN CRYSTAL PROTEINTITL 3 (GALECTIN-10): A CRYSTALLOGRAPHIC STUDY AT 1.8 ATITL 4 RESOLUTIONREF BIOCHEMISTRY V. 38 13837 1999REFN ISSN 0006-2960PMID 10563827 Variant Set Distributions Mapped Variants
General Structure Information 3gwx PPARD molecular recognition of fatty acids by peroxisome proliferator-activated receptors 2.4Å AUTH H.E.XU,M.H.LAMBERT,V.G.MONTANA,D.J.PARKS,AUTH 2 S.G.BLANCHARD,P.J.BROWN,D.D.STERNBACH,J.M.LEHMANN,AUTH 3 G.B.WISELY,T.M.WILLSON,S.A.KLIEWER,M.V.MILBURNTITL MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOMETITL 2 PROLIFERATOR-ACTIVATED RECEPTORS.REF MOL.CELL V. 3 397 1999REFN ISSN 1097-2765PMID 10198642DOI 10.1016/S1097-2765(00)80467-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants