Assessment of Structural Intolerance and Durability
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2cfv PTPRJ crystal structure of human protein tyrosine phosphatase receptor type j 2.5Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cfv PTPRJ crystal structure of human protein tyrosine phosphatase receptor type j 2.5Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cfv PTPRJ crystal structure of human protein tyrosine phosphatase receptor type j 2.5Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2e50 SET crystal structure of set/taf-1beta/inhat 2.3Å AUTH S.MUTO,M.SENDA,Y.AKAI,L.SATO,T.SUZUKI,R.NAGAI,T.SENDA,AUTH 2 M.HORIKOSHITITL RELATIONSHIP BETWEEN THE STRUCTURE OF SET/TAF-IBETA/INHATTITL 2 AND ITS HISTONE CHAPERONE ACTIVITYREF PROC.NATL.ACAD.SCI.USA V. 104 4285 2007REFN ISSN 0027-8424PMID 17360516DOI 10.1073/PNAS.0603762104 Variant Set Distributions Mapped Variants
General Structure Information 2p8u HMGCS1 crystal structure of human 3-hydroxy-3-methylglutaryl coa synthase i 2.0Å AUTH N.SHAFQAT,A.TURNBULL,J.ZSCHOCKE,U.OPPERMANN,W.W.YUETITL CRYSTAL STRUCTURES OF HUMAN HMG-COA SYNTHASE ISOFORMSTITL 2 PROVIDE INSIGHTS INTO INHERITED KETOGENESIS DISORDERS ANDTITL 3 INHIBITOR DESIGN.REF J.MOL.BIOL. V. 398 497 2010REFN ISSN 0022-2836PMID 20346956DOI 10.1016/J.JMB.2010.03.034 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bxm FOLH1 structure of an inactive mutant of human glutamate carboxypeptidase ii [gcpii(e424a)] in complex with n-acetyl-asp-glu (naag) 1.71Å AUTH V.KLUSAK,C.BARINKA,A.PLECHANOVOVA,P.MLCOCHOVA,J.KONVALINKA,AUTH 2 L.RULISEK,J.LUBKOWSKITITL REACTION MECHANISM OF GLUTAMATE CARBOXYPEPTIDASE II REVEALEDTITL 2 BY MUTAGENESIS, X-RAY CRYSTALLOGRAPHY, AND COMPUTATIONALTITL 3 METHODS.REF BIOCHEMISTRY V. 48 4126 2009REFN ISSN 0006-2960PMID 19301871DOI 10.1021/BI900220S Variant Set Distributions Ripley’s […]
General Structure Information 4kx9 ENPEP crystal structure of human aminopeptidase a complexed with arginine 2.25Å AUTH Y.YANG,C.LIU,Y.L.LIN,F.LITITL STRUCTURAL INSIGHTS INTO CENTRAL HYPERTENSION REGULATION BYTITL 2 HUMAN AMINOPEPTIDASE A.REF J.BIOL.CHEM. V. 288 25638 2013REFN ISSN 0021-9258PMID 23888046DOI 10.1074/JBC.M113.494955 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yd9 PTPRS crystal structure of the n-terminal ig1-3 module of human receptor protein tyrosine phosphatase sigma 2.6Å AUTH C.H.COLES,Y.SHEN,A.P.TENNEY,C.SIEBOLD,G.C.SUTTON,W.LU,AUTH 2 J.T.GALLAGHER,E.Y.JONES,J.G.FLANAGAN,A.R.ARICESCUTITL PROTEOGLYCAN-SPECIFIC MOLECULAR SWITCH FOR RPTP SIGMATITL 2 CLUSTERING AND NEURONAL EXTENSION.REF SCIENCE V. 332 484 2011REFN ISSN 0036-8075PMID 21454754DOI 10.1126/SCIENCE.1200840 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]