Assessment of Structural Intolerance and Durability
General Structure Information 4if8 SERPINA12 structure of vaspin 2.08Å AUTH J.T.HEIKER,N.KLOTING,P.KOVACS,E.B.KUETTNER,N.STRATER,AUTH 2 S.SCHULTZ,M.KERN,M.STUMVOLL,M.BLUHER,A.G.BECK-SICKINGERTITL VASPIN INHIBITS KALLIKREIN 7 BY SERPIN MECHANISMREF CELL.MOL.LIFE SCI. V. 70 2569 2013REFN ISSN 1420-682XPMID 23370777DOI 10.1007/S00018-013-1258-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2eef PPP1R3B solution structure of the cbm_21 domain from human protein phosphatase 1, regulatory (inhibitor) subunit 3b -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CBM_21 DOMAIN FROM HUMANTITL 2 PROTEIN PHOSPHATASE 1, REGULATORY (INHIBITOR)TITL 3 SUBUNIT 3BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2okv DTD1 c-myc dna unwinding element binding protein 2.0Å AUTH M.KEMP,B.BAE,J.P.YU,M.GHOSH,M.LEFFAK,S.K.NAIRTITL STRUCTURE AND FUNCTION OF THE C-MYC DNA-UNWINDINGTITL 2 ELEMENT-BINDING PROTEIN DUE-B.REF J.BIOL.CHEM. V. 282 10441 2007REFN ISSN 0021-9258PMID 17264083DOI 10.1074/JBC.M609632200 Variant Set Distributions Mapped Variants
General Structure Information 2wt8 MCPH1 structure of the n-terminal brct domain of human microcephalin (mcph1) 1.6Å AUTH M.W.RICHARDS,J.W.C.LEUNG,S.M.ROE,J.CHEN,R.BAYLISSTITL A POCKET ON THE SURFACE OF THE N-TERMINAL BRCTTITL 2 DOMAIN OF MCPH1 IS REQUIRED TO PREVENT ABNORMALTITL 3 CHROMOSOME CONDENSATION.REF J.MOL.BIOL. V. 395 908 2010REFN ISSN 0022-2836PMID 19925808DOI 10.1016/J.JMB.2009.11.029 Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 4lev MB21D1 structure of human cgas 1.95Å AUTH X.LI,C.SHU,G.YI,C.T.CHATON,C.L.SHELTON,J.DIAO,X.ZUO,C.C.KAO,AUTH 2 A.B.HERR,P.LITITL CYCLIC GMP-AMP SYNTHASE IS ACTIVATED BY DOUBLE-STRANDEDTITL 2 DNA-INDUCED OLIGOMERIZATION.REF IMMUNITY V. 39 1019 2013REFN ISSN 1074-7613PMID 24332030DOI 10.1016/J.IMMUNI.2013.10.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2daf IQUB solution structure of the novel identified ubiquitin-like domain in the human hypothetical protein flj35834 -1.0Å AUTH C.ZHAO,T.KIGAWA,K.SAITO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE NOVEL IDENTIFIEDTITL 2 UBIQUITIN-LIKE DOMAIN IN THE HUMAN HYPOTHETICALTITL 3 PROTEIN FLJ35834REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4mwi MLKL crystal structure of the human mlkl pseudokinase domain 1.7Å AUTH J.M.MURPHY,I.S.LUCET,J.M.HILDEBRAND,M.C.TANZER,S.N.YOUNG,AUTH 2 P.SHARMA,G.LESSENE,W.S.ALEXANDER,J.J.BABON,J.SILKE,AUTH 3 P.E.CZABOTARTITL INSIGHTS INTO THE EVOLUTION OF DIVERGENT NUCLEOTIDE-BINDINGTITL 2 MECHANISMS AMONG PSEUDOKINASES REVEALED BY CRYSTALTITL 3 STRUCTURES OF HUMAN AND MOUSE MLKL.REF BIOCHEM.J. V. 457 369 2014REFN ISSN 0264-6021PMID 24219132DOI 10.1042/BJ20131270 Variant Set Distributions Ripley’s K […]
General Structure Information 2cxy ARID1B crystal structure of the hbaf250b at-rich interaction domain (arid) 1.6Å AUTH A.SHIMADA,H.NIWA,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE HBAF250B AT-RICHTITL 2 INTERACTION DOMAIN (ARID)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gk9 PIP4K2C human phosphatidylinositol-4-phosphate 5-kinase, type ii, gamma 2.8Å AUTH A.G.THORSELL,J.UPPENBERG,M.HOGBOM,D.OGG,AUTH 2 C.ARROWSMITH,H.BERGLUND,R.COLLINS,A.EDWARDS,M.EHN,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 T.KOTENYOVA,P.NILSSON-EHLE,P.NORDLUND,T.NYMAN,AUTH 5 J.SAGEMARK,P.STENMARK,M.SUNDSTROM,S.VAN DEN BERG,AUTH 6 J.WEIGELT,L.HOLMBERG-SCHIAVONE,C.PERSSON,AUTH 7 B.M.HALLBERGTITL STRUCTURE OF HUMANTITL 2 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE, TYPETITL 3 II, GAMMAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2l0y CHCHD4 complex hmia40-hcox17 -1.0Å AUTH L.BANCI,I.BERTINI,C.CEFARO,L.CENACCHI,S.CIOFI-BAFFONI,AUTH 2 I.C.FELLI,A.GALLO,L.GONNELLI,E.LUCHINAT,D.SIDERIS,AUTH 3 K.TOKATLIDISTITL MOLECULAR CHAPERONE FUNCTION OF MIA40 TRIGGERS CONSECUTIVETITL 2 INDUCED FOLDING STEPS OF THE SUBSTRATE IN MITOCHONDRIALTITL 3 PROTEIN IMPORT.REF PROC.NATL.ACAD.SCI.USA V. 107 20190 2010REFN ISSN 0027-8424PMID 21059946DOI 10.1073/PNAS.1010095107 Variant Set Distributions Mapped Variants