Assessment of Structural Intolerance and Durability
General Structure Information 2yry PLEKHA6 solution structure of the ph domain of pleckstrin homology domain-containing family a member 6 from human -1.0Å AUTH H.LI,M.SATO,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PLECKSTRINTITL 2 HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 6 FROMTITL 3 HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2i32 ASF1A structure of a human asf1a-hira complex and insights into specificity of histone chaperone complex assembly 2.7Å AUTH Y.TANG,M.V.POUSTOVOITOV,K.ZHAO,M.GARFINKEL,AUTH 2 A.CANUTESCU,R.DUNBRACK,P.D.ADAMS,R.MARMORSTEINTITL STRUCTURE OF A HUMAN ASF1A-HIRA COMPLEX ANDTITL 2 INSIGHTS INTO SPECIFICITY OF HISTONE CHAPERONETITL 3 COMPLEX ASSEMBLY.REF NAT.STRUCT.MOL.BIOL. V. 13 921 2006REFN ISSN 1545-9993PMID 16980972DOI 10.1038/NSMB1147 Variant Set Distributions Mapped […]
General Structure Information 2lom HIGD1A backbone structure of human membrane protein higd1a -1.0Å AUTH C.KLAMMT,I.MASLENNIKOV,M.BAYRHUBER,C.EICHMANN,N.VAJPAI,AUTH 2 E.J.CHIU,K.Y.BLAIN,L.ESQUIVIES,J.H.KWON,B.BALANA,U.PIEPER,AUTH 3 A.SALI,P.A.SLESINGER,W.KWIATKOWSKI,R.RIEK,S.CHOETITL FACILE BACKBONE STRUCTURE DETERMINATION OF HUMAN MEMBRANETITL 2 PROTEINS BY NMR SPECTROSCOPY.REF NAT.METHODS V. 9 834 2012REFN ISSN 1548-7091PMID 22609626DOI 10.1038/NMETH.2033 Variant Set Distributions Mapped Variants
General Structure Information 2kbc INSL5 solution structure of human insulin-like peptide 5 (insl5) -1.0Å AUTH M.A.HOSSAIN,N.L.DALY,D.J.CRAIK,J.D.WADE,AUTH 2 K.J.ROSENGRENTITL STRUCTURE OF HUMAN INSULIN-LIKE PEPTIDE 5 ANDTITL 2 CHARACTERIZATION OF CONSERVED HYDROGEN BONDS ANDTITL 3 ELECTROSTATIC INTERACTIONS WITHIN THE RELAXINTITL 4 FRAMEWORKREF BIOCHEM.J. V. 419 619 2009REFN ISSN 0264-6021PMID 19178384DOI 10.1042/BJ20082353 Variant Set Distributions Mapped Variants
General Structure Information 3ps4 MAST1 pdz domain from human microtubule-associated serine/threonine-protein kinase 1 1.85Å AUTH E.UGOCHUKWU,J.WANG,T.KROJER,J.R.C.MUNIZ,R.SETHI,A.C.W.PIKE,AUTH 2 A.ROOS,E.SALAH,R.COCKING,P.SAVITSKY,D.A.DOYLE,F.VON DELFT,AUTH 3 C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,S.KNAPP,AUTH 4 J.M.ELKINS,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL PDZ DOMAIN FROM HUMAN MICROTUBULE-ASSOCIATEDTITL 2 SERINE/THREONINE-PROTEIN KINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2m9x MAST1 solution nmr structure of microtubule-associated serine/threonine- protein kinase 1 from homo sapiens, northeast structural genomics consortium (nesg) target hr9151a -1.0Å AUTH X.XU,A.ELETSKY,R.SHASTRY,D.LEE,K.HAMILTON,R.XIAO,T.B.ACTON,AUTH 2 J.K.EVERETT,G.T.MONTELIONE,T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF MICROTUBULE-ASSOCIATEDTITL 2 SERINE/THREONINE-PROTEIN KINASE 1 FROM HOMO SAPIENS,TITL 3 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGETTITL 4 HR9151AREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2ekf AUP1 solution structure of ruh-075, a human cue domain -1.0Å AUTH A.Z.M.RUHUL MOMEN,H.HIROTA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RUH-075, A HUMAN CUE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4hhv COL4A3BP crystal structure of ceramide transfer protein pleckstrin homology domain 1.75Å AUTH J.PRASHEK,T.TRUONG,X.YAOTITL CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM THETITL 2 CERAMIDE TRANSFER PROTEIN: IMPLICATIONS FOR CONFORMATIONALTITL 3 CHANGE UPON LIGAND BINDING.REF PLOS ONE V. 8 79590 2013REFN ESSN 1932-6203PMID 24260258DOI 10.1371/JOURNAL.PONE.0079590 Variant Set Distributions Mapped Variants
General Structure Information 2v9r ROBO1 first and second ig domains from human robo1 (form 2) 2.0Å AUTH C.MORLOT,N.M.THIELENS,R.B.RAVELLI,W.HEMRIKA,R.A.ROMIJN,AUTH 2 P.GROS,S.CUSACK,A.A.MCCARTHYTITL STRUCTURAL INSIGHTS INTO THE SLIT-ROBO COMPLEX.REF PROC.NAT.ACAD.SCI.USA V. 104 14923 2007REFN ISSN 0027-8424PMID 17848514DOI 10.1073/PNAS.0705310104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3c5w PPME1 complex between pp2a-specific methylesterase pme-1 and pp2a core enzyme 2.8Å AUTH Y.XING,Z.LI,Y.CHEN,J.B.STOCK,P.D.JEFFREY,Y.SHITITL STRUCTURAL MECHANISM OF DEMETHYLATION AND INACTIVATION OFTITL 2 PROTEIN PHOSPHATASE 2A.REF CELL(CAMBRIDGE,MASS.) V. 133 154 2008REFN ISSN 0092-8674PMID 18394995DOI 10.1016/J.CELL.2008.02.041 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants