Assessment of Structural Intolerance and Durability
General Structure Information 4ap6 POFUT2 crystal structure of human pofut2 e54a mutant in complex with gdp- fucose 3.401Å AUTH C.I.CHEN,J.J.KEUSCH,D.KLEIN,D.HESS,J.HOFSTEENGE,H.GUTTITL STRUCTURE OF HUMAN POFUT2: INSIGHTS INTO THROMBOSPONDINTITL 2 TYPE 1 REPEAT FOLD AND O-FUCOSYLATION.REF EMBO J. V. 31 3183 2012REFN ISSN 0261-4189PMID 22588082DOI 10.1038/EMBOJ.2012.143 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1nbq F11R crystal structure of human junctional adhesion molecule type 1 2.9Å AUTH A.E.PROTA,J.A.CAMPBELL,P.SCHELLING,J.C.FORREST,AUTH 2 M.J.WATSON,T.R.PETERS,M.AURRAND-LIONS,B.A.IMHOF,AUTH 3 T.S.DERMODY,T.STEHLETITL CRYSTAL STRUCTURE OF HUMAN JUNCTIONAL ADHESIONTITL 2 MOLECULE 1: IMPLICATIONS FOR REOVIRUS BINDINGREF PROC.NATL.ACAD.SCI.USA V. 100 5366 2003REFN ISSN 0027-8424PMID 12697893DOI 10.1073/PNAS.0937718100 Variant Set Distributions Mapped Variants
General Structure Information 3fg6 SCIN structure of the c-terminus of adseverin 3.0Å AUTH S.CHUMNARNSILPA,W.L.LEE,S.NAG,B.KANNAN,M.LARSSON,AUTH 2 L.D.BURTNICK,R.C.ROBINSONTITL THE CRYSTAL STRUCTURE OF THE C-TERMINUS OF ADSEVERIN REVEALSTITL 2 THE ACTIN-BINDING INTERFACE.REF PROC.NATL.ACAD.SCI.USA V. 106 13719 2009REFN ISSN 0027-8424PMID 19666531DOI 10.1073/PNAS.0812383106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ihr UCHL5 crystal structure of uch37 2.95Å AUTH S.E.BURGIE,C.A.BINGMAN,A.B.SONI,G.N.PHILLIPSTITL STRUCTURAL CHARACTERIZATION OF HUMAN UCH37.REF PROTEINS 2011REFN ESSN 1097-0134PMID 21953935DOI 10.1002/PROT.23147 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2p64 BTRC d domain of b-trcp 2.5Å AUTH X.TANG,S.ORLICKY,Z.LIN,A.WILLEMS,D.NECULAI,D.CECCARELLI,AUTH 2 F.MERCURIO,B.H.SHILTON,F.SICHERI,M.TYERSTITL SUPRAFACIAL ORIENTATION OF THE SCFCDC4 DIMER ACCOMMODATESTITL 2 MULTIPLE GEOMETRIES FOR SUBSTRATE UBIQUITINATION.REF CELL(CAMBRIDGE,MASS.) V. 129 1165 2007REFN ISSN 0092-8674PMID 17574027DOI 10.1016/J.CELL.2007.04.042 Variant Set Distributions Mapped Variants
General Structure Information 2izs CSNK1G3 structure of casein kinase gamma 3 in complex with inhibitor 1.95Å AUTH G.BUNKOCZI,E.SALAH,P.RELLOS,S.DAS,O.FEDOROV,P.SAVITSKY,AUTH 2 J.E.DEBRECZENI,O.GILEADI,M.SUNDSTROM,A.EDWARDS,C.ARROWSMITH,AUTH 3 J.WEIGELT,F.VON DELFT,S.KNAPPTITL INHIBITOR BINDING BY CASEIN KINASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jil GRIP1 crystal structure of 2nd pdz domain of glutamate receptor interacting protein-1 (grip1) 1.5Å AUTH J.TICKLE,J.ELKINS,A.C.W.PIKE,C.COOPER,E.SALAH,AUTH 2 E.PAPAGRIGORIOU,F.VON DELFT,A.EDWARDS,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,M.SUNDSTROM,D.DOYLETITL CRYSTAL STRUCTURE OF 2ND PDZ DOMAIN OF GLUTAMATE RECEPTORTITL 2 INTERACTING PROTEIN-1 (GRIP1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4c0p TNPO3 unliganded transportin 3 2.95Å AUTH G.N.MAERTENS,N.J.COOK,W.WANG,S.HARE,S.S.GUPTA,I.OZTOP,K.LEE,AUTH 2 V.E.PYE,O.COSNEFROY,A.P.SNIJDERS,V.N.KEWALRAMANI,A.FASSATI,AUTH 3 A.ENGELMAN,P.CHEREPANOVTITL STRUCTURAL BASIS FOR NUCLEAR IMPORT OF SPLICING FACTORS BYTITL 2 HUMAN TRANSPORTIN 3.REF PROC.NATL.ACAD.SCI.USA V. 111 2728 2014REFN ISSN 0027-8424PMID 24449914DOI 10.1073/PNAS.1320755111 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dad FHOD1 crystal structure of the n-terminal regulatory domains of the formin fhod1 2.3Å AUTH A.SCHULTE,B.STOLP,A.SCHONICHEN,O.PYLYPENKO,A.RAK,AUTH 2 O.T.FACKLER,M.GEYERTITL THE HUMAN FORMIN FHOD1 CONTAINS A BIPARTITETITL 2 STRUCTURE OF FH3 AND GTPASE-BINDING DOMAINSTITL 3 REQUIRED FOR ACTIVATION.REF STRUCTURE V. 16 1313 2008REFN ISSN 0969-2126PMID 18786395DOI 10.1016/J.STR.2008.06.008 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4dl3 POLH human dna polymerase eta inserting dcmpnpp opposite gg template (gg0b). 2.1Å AUTH Y.ZHAO,C.BIERTUMPFEL,M.T.GREGORY,Y.J.HUA,F.HANAOKA,W.YANGTITL STRUCTURAL BASIS FOR CHEMORESISTANCE TO CISPLATIN MEDIATEDTITL 2 BY DNA POLYMERASE ETAREF PROC.NATL.ACAD.SCI.USA V. 109 7269 2012REFN ISSN 0027-8424PMID 22529383DOI 10.1073/PNAS.1202681109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants