Assessment of Structural Intolerance and Durability
General Structure Information 2heh KIF2C crystal structure of the kif2c motor domain (casp target) 2.15Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE KIF2C MOTOR DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2coa PRKD2 solution structure of the ph domain of protein kinase c, d2 type from human -1.0Å AUTH H.LI,K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PROTEINTITL 2 KINASE C, D2 TYPE FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3tfy NAA50 naa50p amino-terminal acetyltransferase bound to substrate peptide fragment and coa 2.75Å AUTH G.LISZCZAK,T.ARNESEN,R.MARMORSTEINTITL STRUCTURE OF A TERNARY NAA50P (NAT5/SAN) N-TERMINALTITL 2 ACETYLTRANSFERASE COMPLEX REVEALS THE MOLECULAR BASIS FORTITL 3 SUBSTRATE-SPECIFIC ACETYLATION.REF J.BIOL.CHEM. V. 286 37002 2011REFN ISSN 0021-9258PMID 21900231DOI 10.1074/JBC.M111.282863 Variant Set Distributions Mapped Variants
General Structure Information 4h5s CADM1 complex structure of necl-2 and crtam 1.7Å AUTH S.ZHANG,G.LU,J.QI,Y.LI,Z.ZHANG,B.ZHANG,Z.FAN,J.YAN,G.F.GAOTITL COMPETITION OF CELL ADHESION AND IMMUNE RECOGNITION:TITL 2 INSIGHTS INTO THE INTERACTION BETWEEN CRTAM AND NECTIN-LIKETITL 3 2REF STRUCTURE V. 21 2013REFN ISSN 0969-2126PMID 23871486DOI 10.1016/J.STR.2013.06.006 Variant Set Distributions Mapped Variants
General Structure Information 2h57 ARL6 crystal structure of human adp-ribosylation factor-like 6 2.0Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,J.LEW,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSYLATIONTITL 2 FACTOR-LIKE 6 (CASP TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lj8 DUSP9 crystal structure of mkp-4 2.7Å AUTH D.G.JEONG,T.S.YOON,S.-K.JUNG,B.C.PARK,H.S.PARK,S.E.RYU,AUTH 2 S.J.KIMTITL EXPLORING BINDING SITES OTHER THAN THE CATALYTIC CORE IN THETITL 2 CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MKP-4REF ACTA CRYSTALLOGR.,SECT.D V. 67 25 2011REFN ISSN 0907-4449PMID 21206059DOI 10.1107/S0907444910042381 Variant Set Distributions Mapped Variants
General Structure Information 1zd1 SULT4A1 human sulfortransferase sult4a1 2.24Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3qrf FOXP3 structure of a domain-swapped foxp3 dimer 2.8Å AUTH H.S.BANDUKWALA,Y.WU,M.FEUERER,Y.CHEN,B.BARBOZA,S.GHOSH,AUTH 2 J.C.STROUD,C.BENOIST,D.MATHIS,A.RAO,L.CHENTITL STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER ON DNA AND ITSTITL 2 FUNCTION IN REGULATORY T CELLS.REF IMMUNITY V. 34 479 2011REFN ISSN 1074-7613PMID 21458306DOI 10.1016/J.IMMUNI.2011.02.017 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4n1d NODAL nodal/bmp2 chimera nb250 1.91Å AUTH L.ESQUIVIES,A.BLACKLER,M.PERAN,C.RODRIGUEZ-ESTEBAN,AUTH 2 J.C.IZPISUA BELMONTE,E.BOOKER,P.C.GRAY,C.AHN,W.KWIATKOWSKI,AUTH 3 S.CHOETITL DESIGNER NODAL/BMP2 CHIMERAS MIMIC NODAL SIGNALING, PROMOTETITL 2 CHONDROGENESIS, AND REVEAL A BMP2-LIKE STRUCTURE.REF J.BIOL.CHEM. V. 289 1788 2014REFN ISSN 0021-9258PMID 24311780DOI 10.1074/JBC.M113.529180 Variant Set Distributions Mapped Variants
General Structure Information 2ovj RACGAP1 the crystal structure of the human rac gtpase activating protein 1 (racgap1) mgcracgap. 1.49Å AUTH L.SHRESTHA,E.PAPAGRIGORIOU,M.SOUNDARARAJAN,J.ELKINS,AUTH 2 C.JOHANSSON,F.VON DELFT,A.C.W.PIKE,N.BURGESS,A.TURNBULL,AUTH 3 J.DEBRECZENI,F.GORREC,C.UMEANO,A.EDWARDS,C.H.ARROWSMITH,AUTH 4 J.WEIGELT,M.SUNDSTROM,D.A.DOYLETITL THE CRYSTAL STRUCTURE OF THE HUMAN RAC GTPASE ACTIVATINGTITL 2 PROTEIN 1 (RACGAP1) MGCRACGAP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants