Assessment of Structural Intolerance and Durability
General Structure Information 4az9 SNX24 crystal structure of phox homology domain of human sorting nexin 24 1.75Å AUTH A.E.OBERHOLZER,W.KIYANI,T.KROJER,L.SHRESTHA,F.VON DELFT,AUTH 2 D.S.FROESE,A.CHAIKUAD,J.RAYNOR,C.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,W.W.YUETITL CRYSTAL STRUCTURE OF PHOX HOMOLOGY DOMAIN OF HUMAN SORTINGTITL 2 NEXIN 24REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3f0w NUMBL human numb-like protein, phosphotyrosine interaction domain 2.7Å AUTH L.LEHTIO,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.D BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,AUTH 4 I.JOHANSSON,T.KARLBERG,T.KOTENYOVA,M.E.NILSSON,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL HUMAN NUMB-LIKE PROTEIN, PHOSPHOTYROSINE INTERACTION DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1xwn PPIL1 solution structure of cyclophilin like 1(ppil1) and insights into its interaction with skip -1.0Å AUTH C.XU,J.ZHANG,X.HUANG,J.SUN,Y.XU,Y.TANG,J.WU,Y.SHI,AUTH 2 Q.HUANG,Q.ZHANGTITL SOLUTION STRUCTURE OF HUMAN PEPTIDYL PROLYLTITL 2 ISOMERASE LIKE PROTEIN 1 AND INSIGHTS INTO ITSTITL 3 INTERACTION WITH SKIPREF J.BIOL.CHEM. V. 281 15900 2006REFN ISSN 0021-9258PMID 16595688DOI 10.1074/JBC.M511155200 Variant Set Distributions Mapped […]
General Structure Information 4dzo MAD1L1 structure of human mad1 c-terminal domain reveals its involvement in kinetochore targeting 1.76Å AUTH S.KIM,H.SUN,D.R.TOMCHICK,H.YU,X.LUOTITL STRUCTURE OF HUMAN MAD1 C-TERMINAL DOMAIN REVEALS ITSTITL 2 INVOLVEMENT IN KINETOCHORE TARGETING.REF PROC.NATL.ACAD.SCI.USA V. 109 6549 2012REFN ISSN 0027-8424PMID 22493223DOI 10.1073/PNAS.1118210109 Variant Set Distributions Mapped Variants
General Structure Information 3h6n PLXND1 crystal structure of the ubiquitin-like domain of plexin d1 2.0Å AUTH Y.TONG,L.NEDYALKOVA,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,M.BUCK,H.PARKTITL CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE DOMAIN OFTITL 2 PLEXIN D1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4h6y FARP1 crystal strucure of the dh-ph-ph domain of farp1 4.09Å AUTH X.HE,Y.C.KUO,T.J.ROSCHE,X.ZHANGTITL STRUCTURAL BASIS FOR AUTOINHIBITION OF THE GUANINETITL 2 NUCLEOTIDE EXCHANGE FACTOR FARP2.REF STRUCTURE V. 21 355 2013REFN ISSN 0969-2126PMID 23375260DOI 10.1016/J.STR.2013.01.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qfv CDC42BPB mrck beta in complex with tpca-1 2.65Å AUTH T.HEIKKILA,E.WHEATLEY,D.CRIGHTON,E.SCHRODER,A.BOAKES,AUTH 2 S.J.KAYE,M.MEZNA,L.PANG,M.RUSHBROOKE,A.TURNBULL,M.F.OLSONTITL CO-CRYSTAL STRUCTURES OF INHIBITORS WITH MRCK BETA , A KEYTITL 2 REGULATOR OF TUMOR CELL INVASION.REF PLOS ONE V. 6 24825 2011REFN ESSN 1932-6203PMID 21949762DOI 10.1371/JOURNAL.PONE.0024825 Variant Set Distributions Mapped Variants
General Structure Information 2vyt SCML2 the mbt repeats of human scml2 bind to peptides containing mono methylated lysine. 1.9Å AUTH C.M.SANTIVERI,B.C.LECHTENBERG,M.D.ALLEN,AUTH 2 A.SATHYAMURTHY,A.M.JAULENT,S.M.V.FREUND,M.BYCROFTTITL THE MALIGNANT BRAIN TUMOR REPEATS OF HUMAN SCML2TITL 2 BIND TO PEPTIDES CONTAINING MONOMETHYLATED LYSINE.REF J.MOL.BIOL. V. 382 1107 2008REFN ISSN 0022-2836PMID 18706910DOI 10.1016/J.JMB.2008.07.081 Variant Set Distributions Mapped Variants
General Structure Information 4bzc SAMHD1 crystal structure of the tetrameric dgtp-bound wild type samhd1 catalytic core 2.88Å AUTH X.JI,Y.WU,J.YAN,J.MEHRENS,H.YANG,M.DELUCIA,C.HAO,AUTH 2 A.M.GRONENBORN,J.SKOWRONSKI,J.AHN,Y.XIONGTITL MECHANISM OF ALLOSTERIC ACTIVATION OF SAMHD1 BY DGTPREF NAT.STRUCT.MOL.BIOL. V. 20 1304 2013REFN ISSN 1545-9993PMID 24141705DOI 10.1038/NSMB.2692 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qor NUDC crystal structure of human nuclear migration protein nudc 1.75Å AUTH M.ZHENG,T.CIERPICKI,A.J.BURDETTE,D.UTEPBERGENOV,P.L.JANCZYK,AUTH 2 U.DEREWENDA,P.T.STUKENBERG,K.A.CALDWELL,Z.S.DEREWENDATITL STRUCTURAL FEATURES AND CHAPERONE ACTIVITY OF THE NUDCTITL 2 PROTEIN FAMILY.REF J.MOL.BIOL. V. 409 722 2011REFN ISSN 0022-2836PMID 21530541DOI 10.1016/J.JMB.2011.04.018 Variant Set Distributions Mapped Variants